List of patents, publications, and presentations. Current as of 2009.

1. terry_clayton@sbcglobal.net Terry S. Clayton 262-641-0536
Patents
Cook, J.M.; Han, D.; Clayton, T. Imidazobenzodiazepines as gabaergic agents to treat memory deficits
and their preparation. U.S. Pat 7,595,395 B2; September 29, 2009.
Cook, J.M.; Clayton, T.; Jain, H.D.; Teng, Y.; Yang, J. Selective Anticonvulsant Agents and Their Uses.
U.S. Pat. Appl. No. 61/038,184; Filed March 2008.
Barndt, J.A.; Barton, R.H.; Clayton, T.S.; Rose, M.J.; Volz, P.G. Printing Using Color Changeable
Material. WO 2009/094063 A1. Pub. July 30, 2009.
Graushar, W.T; Barndt, J.A.; Barton, R.H.; Clayton, T.S..; Ablative Printing. US 2009/0128860 A1;
Pub. May 21, 2009.
Roth, B.; Clayton, T. Device, method, and composition for reducing the incidence of tobacco smoking. U.S.
Pat. Appl. 20060130857; Filed September 30, 2005.
Publications
Miroslav M Savic, Ph.D.; Samarpan Majumder; Shengming Huang; Rahul V Edwankar;
Roman Furtmüller; Srđan Joksimović; Terry Clayton Sr; Joachim Ramerstorfer; Marija M
Milinković; Bryan L Roth; Werner Sieghart; James M Cook Novel positive allosteric modulators
of GABAA receptors: Do subtle differences in activity at a1 plus a5 versus a2 plus a3 subunits
account for dissimilarities in behavioral effects in rats? Progress in Neuro-Psychopharmacology &
Biological Psychiatry. Accepted in January 2010.
Grant, J.A., Bonnick, T., Gossell-Williams, M., Clayton, T., Cook, J.M., Jackson, Y.A., Synthesis,
pharmacological studies and molecular modeling of some tetracyclic 1,3-diazepinium chlorides.
Bioorg. Med. Chem. xxx (2009) xxx–xxx. Available online.
Takahashi, A.; Yap, J.J.; Bohager, D.Z.; Faccidomo, S.; Clayton, T.; Cook, J.M.; Miczek, K.A
Glutamatergic and GABAergic Modulations of Ultrasonic Vocalizations During Maternal
Separation Distress in Mouse Pups. Psychopharmacol. (Berlin, Ger.) , 204, pp 61-71 (2009).
Han, D., Forsterling, H.F., Li, X., Deschamps, J.R., Parrish, D., Cao, H., Rallapalli, S., Clayton, T. ,
Teng, Y., Majumder, S., Sankar, S., Roth, B.L., Sieghart, W., Furtmuller, R., J.K. , Weed, M.R.,
Cook, J.M. A Study of the Structure-activity Relationship of GABAA-benzodiazepine Receptor
Bivalent Ligands by Conformational Analysis with low Temperature NMR and X-ray Analysis,
Bioorg. and Med. Chem., 16, 8853-8862 (2008).
Savic, M.M.; Milinkovic, M.M.; Clayton, T.; Rallapalli, R.; Joksimovic, Van linn, M.; Cook, J.M.;
The differential role of α1 and α5 containing GABAA receptors in mediating diazepam effects on
spontaneous locomotor activity and water maze learning and memory in rats. International
Journal of Neuropsychopharmacology, 12, pp 1179-1193 (2009).
Savic, M. M.; Clayton, T.; Furtmuller, R.; Gavrilovic, I.; Samardzic, J.; Savic, S.; Huck, S.; Sierhart,

2. terry_clayton@sbcglobal.net Terry S. Clayton 262-641-0536
W.; Cook, J. M.; PWZ-029, A compound with moderate inverse agonist functional selectivity at
GABAA receptors containing α5 subunits, improves passive, but not active, avoidance learning
in rats. Brain Research, 2008,1208, pp 150-159.
Danni Harris, Terry Clayton, James Cook, Robert Halliwell, Peyman Sahbaie, Roman Furtmuller,
Sigismund Huck, Werner Sieghart,Timothy M. DeLorey; Selective Influence on Contextual
Memory: Physiochemical Properties Associated with Selectivity of Benzodiazepine Ligands at
GABAA Receptors Containing the α5 Subunit. J. Med. Chem., 2008, 51 (13), pp 3788–3803.
T. Clayton, J.L. Chen, M. Ernst, L. Richter, B.A. Cromer, C.J. Morton, H. Ng, C.C. Kaczorowski,
F.J. Helmstetter, R. Furtmüller, G. Ecker, M.W. Parker, W. Sieghart and J.M. Cook.; Analysis of
the Benzodiazepine Binding Site on γ-Aminobutyric acidA Receptors: Correlation of
Experimental Data with Pharmacophore and Comparative Models, Current Medicinal Chemistry;
vol. 14, number 26, Pp. 2755-2775; 2007.
Savic, M.M., Huang, S., Furtmüeller, R., Clayton, T., Huck, S., Obradović, D.I., Ugrešić, N.D.,
Sieghart, W., Bokonjić, D.R., Cook, J.M.; Are GABAA Receptors Containing α5 Subunits
Contributing to the Sedative Properties of Benzodiazepine Site Agonists?
Neuropsychopharmacology, 2008, 33, pp 332–339.
Presentations
Clayton, Terry; Synthesis of subtype selective ligands and molecular modeling for alpha-5
containing GABAA/Bz receptors to treat memory deficits. 235th ACS National Meeting, New
Orleans, LA United States, April 6-10th , 2008.
J. A. Grant, Y. A. Jackson, M. Gossell-Williams, T. Bonnick, T. Clayton and J. M. Cook;
Synthesis, Pharmacological Studies and Molecular Modeling of Novel Tetracyclic 1,3-
nd
Diazepinium Chlorides The 22 Mona Symposium on Natural Products and Medicinal
Chemistry, Mona Jamaica, January 7-10 (2008).
James M. Cook, Harry June, Elise Weerts, Micheal L. Van Linn, Donna Platt, Tim
DeLorey, Miroslav Savic, Terry Clayton. Serendipity rediscovered — an oxymoron or rational
drug design: Studies on subtype selective BzR/GABAergic ligands. Division of Medicinal
Chemistry-234th ACS National Meeting Boston, MA August 19-23, 2007.
Clayton, T.; Synthesis of Subtype Selective Ligands for Alpha 5-Containing GABAA/Bz Receptors
to Treat Memory Deficits. 233rd ACS National Meeting, Chicago, IL, United States, March 25-29th,
2007.
Huang, Shengming; Savic, Miroslav; Furtmuller, Roman; Duke, Angela; Clayton, Terry; Sieghart,
Werner; Rowlett, James K.; Cook, James M. Design and synthesis of stereoenantiomeric benzodiazepine
receptor ligands. Abstract of Papers, 233rd ACS National Meeting, Chicago, IL, United States,
March 25-29th, 2007.

3. terry_clayton@sbcglobal.net Terry S. Clayton 262-641-0536
Platt, D.M.; Cook, J.M.; Van Linn, M.L.; Clayton, T.S.; GABA-A/alpha5 Receptor Mechanisms in
the Discriminative Stimulus Effects of GABA-A Modulators. CPDD Meeting, Quebec, Canada.
June 16-21, 2007.
M. Weed, T. Clayton, J.M. Cook, Ry-023, a Selective Inverse Agonist at the Benzodiazepine
Binding Site on the GABA-A α5 Receptor, Improves Performance in a Delayed-Match-to-Sample
Task in Rhesus Monkeys. 46th American College of Neuropsychopharmacology, December 9-13,
Boca Raton, FL, Abst. #158 (2007).
Faccidomo, S.; Maggin, J.G.; Melief, S.; Clayton, T.S.; Cook, J.M.; Miczek, K.A. Modulation of
Alcohol-Heightened Aggression in Mice by a5-Containing GABAA Receptors; Society for Neuroscience,
Atlanta, GA October, 2006.
Grant, J.A..; Jackson, Y.A.; Gossel-Williams, M.; Clayton, T.; Cook, J.M.; Synthesis, Pharmacological
Studies, and Molecular Modeling of Novel 1,3-Diazipinium Chlorides. In Latest Trends in Organic
Synthesis, Brock University, St. Catherines, Ontario, 2006.
Clayton, T.; Sanker, S.; Delorey, T.; Sieghart, W.; Furtmueller, R.; Wenger, G.; Cook, J.M.;
Synthesis of Subtype Selective Ligands for α5-Containing GABA /Bz Receptors to Treat Memory Deficits.
A
ACS, Milwaukee, WI, May, 2006.
S. Huang, T. Clayton, M. Dai, W. Yin, J. Ma, R. Edwankar, C. Sawant, M. Van Linn, Y. Teng, M.
Johnson, H. F. Forsterling, and J. M. Cook; The SAR Study of Benzodiazepine Receptor Bivalent
th
Ligands by Low Temperature NMR Spectroscopy and X-Ray Analysis , Abstracts, 37 Great Lakes
Regional Meeting of the American Chemical Society, Milwaukee, WI May 31 – June 2, 2006,
GLRM-155.
S. Huang, T. Clayton, M. Dai, R. Edwankar, C. Sawant, J. M. Cook Synthesis of Optically Active
nd
Subtype Selective BZR Ligands,”, Abstracts of Papers, 232 ACS National Meeting, San
Francisco, CA, Sept. 10-14, 2006, MEDI-502.
Clayton, T., Prodrug Design and Synthesis, Graduate Seminar, Milwaukee, WI 2004.
Clayton, T., Stripping Potentiometry Studies of Inorganic Arsenic Oxyanions at Trace Levels,
Awards Day Finalist, Milwaukee, WI, 2003.
Clayton, T.; Chemistry and Art. National Chemistry Week. Discovery World, ACS - Milwaukee
Section, Milwaukee, WI, 2001.