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Common Gynaecological
Disorders
  Dr. Lee Chin Peng
  Honorary Clinical Associate Professor
  Department of Obstetrics and Gynaecology
  University of Hong Hong
Outline
 General approach to gynaecological
 problems
 Management and recent advances:
   vaginal discharge
   abnormal vaginal bleeding
   dysmenorrhoea
   uterine fibroid
 Useful resources
History and physical examination
 Menstrual history, LMP
 Contraception
 Cervical smear history
 Can the patient be pregnant?
 Obstetric history
 Patient’s concerns
 Is pelvic examination necessary?
Investigations
 Pregnancy test
 Swabs for culture
 Cervical smear
 Endometrial aspiration
 Ultrasound pelvis
Need referral?
Reasons for referral:
1. Unsure diagnosis
2. Special diagnostic tests
3. Treatment
4. Second opinion
Many common gynaecological problems can
  be managed by GP
Should investigations be done
before referral ?

1. Affect decision to refer?

2. Delay the referral?

3. Reliable laboratory?
Referral letter
  Name and age of the patient
  Reason for referral
  Any investigations and treatment before the
  referral
  Wish to continue post-referral care
Ix reports, copies of X-ray, ultrasound images
  are very helpful
Reply from hospital specialist,
follow up
1. Confirm with patient: diagnosis, treatment
  and plan of management
2. Clarify with specialist if needed
3. Your feedback is welcomed
Vaginal Discharge
 Physiological:
    midcycle, premenstrual
 Pathological:
    odour, itchiness
    blood stained
 Postmenopausal: atrophic vaginitis
May need to explore hidden anxiety,
 especially anxiety about STD
Vaginal Discharge
 Speculum examination is necessary and
 digital examination preferred
 Need to take culture swab?
   Typical moniliasis: treat without culture, take
   swab if treatment fails
 Need to screen for STD?
Vaginal Discharge
Need to refer?
    Recurrent
    Blood stained and not midcycle
    Fail to response to treatment
    Uterine or cervical pathology suspected
    Postmenopausal and fails to respond to HRT
Vaginal Discharge
In children:
Think of foreign body and
? Sexual abuse
May need referral
Abnormal vaginal bleeding
 Postmenopausal bleeding (PMB)
 Reproductive age group:
   irregular
   inter-, pre- or post-menstrual spotting
   heavy bleeding (menorrhagia)
Abnormal vaginal bleeding
 Malignancies?
   Carcinoma of corpus
   Carcinoma of cervix
   Oestrogen producing ovarian tumour
 Premaligant conditions?
   Atypical endometrial hyperplasia
   CIN (usually do not present with bleeding)
Abnormal vaginal bleeding
 Benign conditions
   Polyps: endometrial, cervical
   Fibroid
   IUCD?
   Drug effect?
   Systemic diseases
   DYSFUNCTIONAL UTERINE BLEEDING
   IS THE MOST COMMOM
Abnormal vaginal bleeding
Assessment of the endometrium (not needed for
  women with very low risk of Ca endometrium)
  endometrial aspirate
  ultrasound pelvis (transvaginal) to assess
  endometrial thickness
  hysteroscopy
Abnormal vaginal bleeding
When to refer:
 over the age of 40
 high risk of endometrial Ca (obesity, DM,
 PCOD)
 uterus > 10 week size or irregular
 cervical pathology suspected
 no response to medical treatment
Abnormal vaginal bleeding:
a practical approach (1)
History:
 age
 pattern of bleeding
 risk factors for endometrial Ca
 pregnant?
 drug
 previous treatment
 last cervical smear
Abnormal vaginal bleeding:
a practical approach (2)

Physical examination
  general: obesity? thyroid? pallor? pulse?
  abdomen: palpable mass?
  pelvis: cervical or vaginal lesion? uterine
  size
Abnormal vaginal bleeding:
a practical approach (3)

Over 40
or high risk of endometrial Ca
or genital tract lesion suspected (except
  cervical polyp), including uterus big
or previous medical treatment fail

REFER (or endometrial aspiration and TV USG)
Abnormal vaginal bleeding:
a practical approach (4)

None of the above factors
 consider investigations
    cervical smear if sexually active and last smear
    more than 1 year ago
    CBP if menorrhagia
    ultrasound pelvis if PV not possible
    thyroid function, coagulation only when history
    suggestive
Abnormal vaginal bleeding:
a practical approach (5)
Medical treatment (for women under 40 with
 no suspicion of organic lesions)
 Hormonal (for irregular bleeding as well as
 menorrhagia)
    combined OC
    progestogen only (21 days needed)
  Non-hormonal (for menorrhagia)
    NSAID
    antifibrinolytic agent
Abnormal vaginal bleeding:
a practical approach (6)

Choice of medical treatment for irregular
 vaginal bleeding:

  combined OC gives much better cycle
  control (start with a preparation containing 50ug EE)

  progestogen only (when oestrogen contraindicated)
Abnormal vaginal bleeding:
a practical approach (7)
Choice of medical treatment for menorrhagia
     NSAID: 30% decrease in blood loss ,relieve
     dysmenorrhoea as well
     Antifibrinolytic (transamine): 50% decrease
     Combined OC: effective but need to take through out
     the month, effective contraception as well
     Progestogen only: less effective, need 21 days, not
     effective contraception
     Haematinics: if anaemic
  combinations can be used
Abnormal vaginal bleeding:
a practical approach (8)


When to consider medical treatment as
 failure?

  Failure to relieve patient’s symptoms after 3
  months
  Remains anaemic after 3 months
Abnormal vaginal bleeding:
other modalities of treatment

 Levonorgesterol releasing IUCD (Mirena)
 Endometrial ablation
    pregnancy contraindicated after ablation
 Hysterectomy
Abnormal vaginal bleeding
Post-referral management

 Pathology excluded
 Treatment plan suggested, e.g
    non-hormonal therapy
    hormonal therapy usually for 6 months
  just follow the treatment plan
  refer back if treatment failure
 Follow up after special treatment
Dysmenorrhoea
 Primary
 Secondary:
   endometriosis
   adenomyosis
   chronic pelvic inflammatory disease
   pelvic adhesions
Primary dysmenorrhoea

 Onset a few years after menarche
 Regular cycles
 Pain for less than 2 days
 Cramping pain
 Nausea, other GI symptoms
 radiation to thigh
 relieved after childbirth, but may recur after some years
Dysmenorrhoea
 History
 Physical examination:
   Is pelvic examination needed?
  Recommended in all cases except in
   teenagers who are not sexually active
   with typical primary dysmenorrhoea
Dysmenorrhoea
Investigations needed?
  Ultrasound pelvis if
    clinical pelvic examination abnormal
    symptoms suggestive of secondary
    dysmenorrhoea but PV not conclusive or not
    possible
  Laparoscopy
    seldom needed
Dysmenorrhoea: role of laparoscopy

 Subfertility
 Chronic pelvic pain
 Relieve the anxiety of patients
 Treatment:
   endometriotic cyst
   medical treatment fail
   subfertility
Dysmenorrhoea
Medical treatment for dysmenorrhoea:
 Simple analgesics: paracetamol, NSAID
  indicated for primary and secondary
    dysmenorrhoea without associated subfertility,
    or ovarian cysts
 Hormonal therapy: as a second line when
 simple analgesia fails
Dysmenorrhoea
Hormonal therapy:
Primary dysmenorrhoea:
  combined OC pills (low EE)


Endometriosis:
  progestogen only
  combined OC pills (low EE)
Uterine fibroids
 Common
 25-30% of women over 35
 Often asymtomatic
 Incidentally detected on pelvic ultrasound
Uterine fibroids
When to refer:
 symptoms related to fibroids
 size > 12 weeks (palpable per abdomen)
 pain
 uncertain diagnosis ?ovarian cyst
 subfertility, recurrent miscarriage
Uterine fibroids
Symptoms related to fibroids:
  menorrhagia
  irregular menstruation (only for submucosal
  fibroids)
  urinary (frequency, retention)
  abdominal distention
Uterine fibroids
How to follow up asymptomatic fibroids?
 Ultrasound?
    Usually no needed
 Check symptoms and uterine size clinically
 every 6 months or ask patient to return if
 symptomatic
Uterine fibroids: treatment
 Surgical treatment remains the mainstay:
   myomectomy (laparotomy, laparoscopy,
   hysterocopy)
   hysterectomy
 Medical treatment with GnRH analogue
    shrink fibroids before surgery
    buy time before menopause
 Embolization: inadequate evidence on
 effectiveness and safety
Uterine fibroids
Post-myomectomy follow up:
  fibroids can recur after myomectomy
  advice for pregnancy?
    When?
    Caesarean delivery needed?
Useful resources

References used for this presentation:

HKCOG: Guidelines on investigation of women with
  abnormal uterine bleeding under the age of 40, HKCOG
  Guidelines 5, May 2001

Pretence A: Medical management of menorrhagia, BMJ
   1999;319:1343-5

Pretence A: Endometriosis, BMJ 2001;323:93-5
Useful resources

Websites:
 hhtp://www.bmj.com
 hhtp://www.rcog.org.uk/guidelines
 hhtp://www.hkcog.org.hk
Thanks to:
Schering (Hong Kong) Ltd.
Subsidiary of Schering AG Germany

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Cgd 2

  • 1. Common Gynaecological Disorders Dr. Lee Chin Peng Honorary Clinical Associate Professor Department of Obstetrics and Gynaecology University of Hong Hong
  • 2. Outline General approach to gynaecological problems Management and recent advances: vaginal discharge abnormal vaginal bleeding dysmenorrhoea uterine fibroid Useful resources
  • 3. History and physical examination Menstrual history, LMP Contraception Cervical smear history Can the patient be pregnant? Obstetric history Patient’s concerns Is pelvic examination necessary?
  • 4. Investigations Pregnancy test Swabs for culture Cervical smear Endometrial aspiration Ultrasound pelvis
  • 5. Need referral? Reasons for referral: 1. Unsure diagnosis 2. Special diagnostic tests 3. Treatment 4. Second opinion Many common gynaecological problems can be managed by GP
  • 6. Should investigations be done before referral ? 1. Affect decision to refer? 2. Delay the referral? 3. Reliable laboratory?
  • 7. Referral letter Name and age of the patient Reason for referral Any investigations and treatment before the referral Wish to continue post-referral care Ix reports, copies of X-ray, ultrasound images are very helpful
  • 8. Reply from hospital specialist, follow up 1. Confirm with patient: diagnosis, treatment and plan of management 2. Clarify with specialist if needed 3. Your feedback is welcomed
  • 9. Vaginal Discharge Physiological: midcycle, premenstrual Pathological: odour, itchiness blood stained Postmenopausal: atrophic vaginitis May need to explore hidden anxiety, especially anxiety about STD
  • 10. Vaginal Discharge Speculum examination is necessary and digital examination preferred Need to take culture swab? Typical moniliasis: treat without culture, take swab if treatment fails Need to screen for STD?
  • 11. Vaginal Discharge Need to refer? Recurrent Blood stained and not midcycle Fail to response to treatment Uterine or cervical pathology suspected Postmenopausal and fails to respond to HRT
  • 12. Vaginal Discharge In children: Think of foreign body and ? Sexual abuse May need referral
  • 13. Abnormal vaginal bleeding Postmenopausal bleeding (PMB) Reproductive age group: irregular inter-, pre- or post-menstrual spotting heavy bleeding (menorrhagia)
  • 14. Abnormal vaginal bleeding Malignancies? Carcinoma of corpus Carcinoma of cervix Oestrogen producing ovarian tumour Premaligant conditions? Atypical endometrial hyperplasia CIN (usually do not present with bleeding)
  • 15. Abnormal vaginal bleeding Benign conditions Polyps: endometrial, cervical Fibroid IUCD? Drug effect? Systemic diseases DYSFUNCTIONAL UTERINE BLEEDING IS THE MOST COMMOM
  • 16. Abnormal vaginal bleeding Assessment of the endometrium (not needed for women with very low risk of Ca endometrium) endometrial aspirate ultrasound pelvis (transvaginal) to assess endometrial thickness hysteroscopy
  • 17. Abnormal vaginal bleeding When to refer: over the age of 40 high risk of endometrial Ca (obesity, DM, PCOD) uterus > 10 week size or irregular cervical pathology suspected no response to medical treatment
  • 18. Abnormal vaginal bleeding: a practical approach (1) History: age pattern of bleeding risk factors for endometrial Ca pregnant? drug previous treatment last cervical smear
  • 19. Abnormal vaginal bleeding: a practical approach (2) Physical examination general: obesity? thyroid? pallor? pulse? abdomen: palpable mass? pelvis: cervical or vaginal lesion? uterine size
  • 20. Abnormal vaginal bleeding: a practical approach (3) Over 40 or high risk of endometrial Ca or genital tract lesion suspected (except cervical polyp), including uterus big or previous medical treatment fail REFER (or endometrial aspiration and TV USG)
  • 21. Abnormal vaginal bleeding: a practical approach (4) None of the above factors consider investigations cervical smear if sexually active and last smear more than 1 year ago CBP if menorrhagia ultrasound pelvis if PV not possible thyroid function, coagulation only when history suggestive
  • 22. Abnormal vaginal bleeding: a practical approach (5) Medical treatment (for women under 40 with no suspicion of organic lesions) Hormonal (for irregular bleeding as well as menorrhagia) combined OC progestogen only (21 days needed) Non-hormonal (for menorrhagia) NSAID antifibrinolytic agent
  • 23. Abnormal vaginal bleeding: a practical approach (6) Choice of medical treatment for irregular vaginal bleeding: combined OC gives much better cycle control (start with a preparation containing 50ug EE) progestogen only (when oestrogen contraindicated)
  • 24. Abnormal vaginal bleeding: a practical approach (7) Choice of medical treatment for menorrhagia NSAID: 30% decrease in blood loss ,relieve dysmenorrhoea as well Antifibrinolytic (transamine): 50% decrease Combined OC: effective but need to take through out the month, effective contraception as well Progestogen only: less effective, need 21 days, not effective contraception Haematinics: if anaemic combinations can be used
  • 25. Abnormal vaginal bleeding: a practical approach (8) When to consider medical treatment as failure? Failure to relieve patient’s symptoms after 3 months Remains anaemic after 3 months
  • 26. Abnormal vaginal bleeding: other modalities of treatment Levonorgesterol releasing IUCD (Mirena) Endometrial ablation pregnancy contraindicated after ablation Hysterectomy
  • 27. Abnormal vaginal bleeding Post-referral management Pathology excluded Treatment plan suggested, e.g non-hormonal therapy hormonal therapy usually for 6 months just follow the treatment plan refer back if treatment failure Follow up after special treatment
  • 28. Dysmenorrhoea Primary Secondary: endometriosis adenomyosis chronic pelvic inflammatory disease pelvic adhesions
  • 29. Primary dysmenorrhoea Onset a few years after menarche Regular cycles Pain for less than 2 days Cramping pain Nausea, other GI symptoms radiation to thigh relieved after childbirth, but may recur after some years
  • 30. Dysmenorrhoea History Physical examination: Is pelvic examination needed? Recommended in all cases except in teenagers who are not sexually active with typical primary dysmenorrhoea
  • 31. Dysmenorrhoea Investigations needed? Ultrasound pelvis if clinical pelvic examination abnormal symptoms suggestive of secondary dysmenorrhoea but PV not conclusive or not possible Laparoscopy seldom needed
  • 32. Dysmenorrhoea: role of laparoscopy Subfertility Chronic pelvic pain Relieve the anxiety of patients Treatment: endometriotic cyst medical treatment fail subfertility
  • 33. Dysmenorrhoea Medical treatment for dysmenorrhoea: Simple analgesics: paracetamol, NSAID indicated for primary and secondary dysmenorrhoea without associated subfertility, or ovarian cysts Hormonal therapy: as a second line when simple analgesia fails
  • 34. Dysmenorrhoea Hormonal therapy: Primary dysmenorrhoea: combined OC pills (low EE) Endometriosis: progestogen only combined OC pills (low EE)
  • 35. Uterine fibroids Common 25-30% of women over 35 Often asymtomatic Incidentally detected on pelvic ultrasound
  • 36. Uterine fibroids When to refer: symptoms related to fibroids size > 12 weeks (palpable per abdomen) pain uncertain diagnosis ?ovarian cyst subfertility, recurrent miscarriage
  • 37. Uterine fibroids Symptoms related to fibroids: menorrhagia irregular menstruation (only for submucosal fibroids) urinary (frequency, retention) abdominal distention
  • 38. Uterine fibroids How to follow up asymptomatic fibroids? Ultrasound? Usually no needed Check symptoms and uterine size clinically every 6 months or ask patient to return if symptomatic
  • 39. Uterine fibroids: treatment Surgical treatment remains the mainstay: myomectomy (laparotomy, laparoscopy, hysterocopy) hysterectomy Medical treatment with GnRH analogue shrink fibroids before surgery buy time before menopause Embolization: inadequate evidence on effectiveness and safety
  • 40. Uterine fibroids Post-myomectomy follow up: fibroids can recur after myomectomy advice for pregnancy? When? Caesarean delivery needed?
  • 41. Useful resources References used for this presentation: HKCOG: Guidelines on investigation of women with abnormal uterine bleeding under the age of 40, HKCOG Guidelines 5, May 2001 Pretence A: Medical management of menorrhagia, BMJ 1999;319:1343-5 Pretence A: Endometriosis, BMJ 2001;323:93-5
  • 42. Useful resources Websites: hhtp://www.bmj.com hhtp://www.rcog.org.uk/guidelines hhtp://www.hkcog.org.hk
  • 43. Thanks to: Schering (Hong Kong) Ltd. Subsidiary of Schering AG Germany