Cytopathology Conference 10/20/05 - Case 3

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Case 3 13-year-old girl with a 3 cm left cheek mass.

Differential Diagnosis ,[object Object],[object Object]

Pleomorphic Adenoma ,[object Object],[object Object],[object Object],[object Object]

Pleomorphic Adenoma: variable appearance Epithelial and mesenchymal elements present. Cystic, papillary, hyalinized or tubular. Backround can have chondroid, myxoid, osteoid.

Pleomorphic Adenoma The stroma is the most outstanding feature. It is intensely metachromatic and stains a beautiful bright (fibrillary) magenta on diff-quick .

Pleomorphic Adenoma Mucous metaplasia and squamous metaplasia

Pleomorphic Adenoma Oncocytic metaplasia and sebaceous metaplasia

Pleomorphic Adenoma Tyrosine crystals and focal atypia

Pleomorphic Adenoma Hyaline Globules: differential - adenoid cystic carcinoma - pleomorphic adenoma - monomorphic adenoma - mucus producing adenocarcinoma - acinic cell carcinoma - others with myoepithelial cells

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