Generic Plavix (Clopivas) contains the active ingredient clopidogrel bisulfate. It is used to prevent blood clots and reduce the risk of heart attack, stroke, or vascular death in patients with acute coronary syndrome, recent heart attack or stroke, or peripheral arterial disease. Common side effects include bleeding, though potentially fatal thrombotic thrombocytopenic purpura has also been reported. It works by inhibiting platelet aggregation and is generally taken long-term at a dose of 75mg daily, with higher loading doses for some conditions.

1. Generic Plavix Tablets
Generic Plavix (Clopidogrel Bisulfate ) is
a platelet inhibitor used to treat patients
with Acute coronary syndrome, recent
myocardial infarction (MI), recent stroke,
or established peripheral arterial
disease.
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2. Generic Plavix Tablets
Clopidogrel bisulfate is a white to off-white
powder. It is practically insoluble in
water at neutral pH but freely soluble at
pH 1.
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3. Generic Plavix Tablets
Generic Plavix is available as Clopivas
manufactured by Cipla Ltd., India. This
medicine is used to prevent blood clots
in coronary artery disease, peripheral
vascular disease, and cerebrovascular
disease.
The active ingredient present in Generic
Plavix (Clopivas Tablets) is Clopidogrel
Bisulfate
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4. Generic Plavix Tablets
Indications
Generic Plavix Tablets is a P2Y12 platelet inhibitor
that is used in the treatment of :
Acute coronary syndrome
- For patients with non-ST-segment elevation ACS
[unstable angina (UA)/ non-ST-elevation myocardial
infarction (NSTEMI)] including patients who are to
be managed medically and those who are to be
managed with coronary revascularization, Plavix
has been shown to decrease the rate of a combined
endpoint of cardiovascular death, myocardial
infarction (MI), or stroke as well as the rate of a
combined endpoint of cardiovascular death, MI,
stroke, or refractory ischemia.
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5. Generic Plavix Tablets
Indications
- For patients with ST-elevation myocardial
infarction (STEMI), Plavix has been shown to
reduce the rate of death from any cause and the
rate of a combined endpoint of death, re-infarction,
or stroke.
Recent myocardial infarction (MI), recent stroke,
or established peripheral arterial disease
Plavix has been shown to reduce the combined
endpoint of new ischemic stroke (fatal or not), new
MI (fatal or not), and other vascular death.
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6. Generic Plavix Tablets
Recommended Dosage
The recommended dosage for the treatment of
various indications is given below:
Acute Coronary Syndrome:
➢ Non-ST-segment elevation ACS (UA/NSTEMI):
300 mg loading dose followed by 75 mg once daily,
in combination with aspirin (75-325 mg once daily)
➢STEMI: 75 mg once daily, in combination with
aspirin (75-325 mg once daily), with or without a
loading dose and with or without thrombolytics
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7. Generic Plavix Tablets
Recommended Dosage
Recent MI, recent stroke, or established
peripheral arterial disease: 75 mg of Generic
Plavix once daily
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8. Generic Plavix Tablets
Contraindications
Clopivas Tablets (Generic Plavix) is
contraindicated in patients with a
hypersensitivity to Clopidogrel Bisulfate or
any inactive component of this medication.
It is also contraindicated in patients with
active pathological bleeding, such as peptic
ulcer or intracranial hemorrhage.
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9. Generic Plavix Tablets
Side Effects of Clopivas Tablets
Bleeding, including life-threatening and fatal
bleeding, is the most commonly reported side
effect.
Thrombotic Thrombocytopenic Purpura
(TTP), sometimes fatal, has been reported
following use of Generic Plavix, sometimes
after a short duration.
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10. Generic Plavix Tablets
Warnings And Precautions
➔Concurrent use of Generic Plavix with
medicines that are strong or moderate CYP2C19
inhibitors have to be avoided
➔Since Generic Plavix increases risk of bleeding,
it has to be discontinued 5 days prior to
undergoing surgery.
➔Premature discontinuation of Clopivas Tablets
increases risk of cardiovascular events.
© The Swiss Pharmacy, Geneva Switzerland

11. Generic Plavix Tablets
Warnings And Precautions
➔Combination use of Generic Plavix and aspirin
in patients with recent transient ischemic attack
or stroke was not shown to be more effective than
Generic Plavix alone.
➔Thrombotic Thrombocytopenic Purpura (TTP)
has been reported with Generic Plavix, including
fatal cases.
© The Swiss Pharmacy, Geneva Switzerland

12. Generic Plavix Tablets
Clopidogrel Bisulfate Tablets
Clopivas Tablets manufactured by
Cipla Ltd. India
For more information click here
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