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HEAT STRESS EFFECTS:

 ISSUES & QUESTIONS




                              DON SPIERS

                       UNIVERSITY OF MISSOURI-COLUMBIA
WHAT IS STRESS?
    (Initial Question)
Stress = the environment or
          stimulus
                 (same for everyone)




Strain = the effect or response
              (different for everyone)
“It’s not stress
that kills us, it
is our reaction
to it.”
“I cannot, and
    should not,
  be cured of my
       stress
    but merely
taught to enjoy it”
  Hans Selye, l950
What is
 heat
strain?
Impaired Functions (the short list)

1. Drop in production

2. Increased days open

3. Depressed immune system

4. Decreased fertility
THE COST
Annual losses in the US
due to heat stress equal
$1.7 billion.

Dairy   =   $897 million

Beef    =   $369 million
PHYSIOLOGICAL CHANGES
1.    Thermal Status

     2.    General Effects

          3.    Immune Condition

               4.    Nutritional Status

                    5.    Behavior

                         6.   Endocrine

                              7.   Reproductive Status
Heat Stress - Physiological Strain

                                     Thermal Status

       1.    ↑ Core Body Temperature – rumen – tympanic – intraperitoneal
                        A.    Total Body Heat Content

       2.    ↑ Respiration Rate and Respiratory Evaporative Heat Loss

       3.    ↑ Skin Temperature, Blood Flow, and Sweat Rate
                        A.    ↓ Blood Flow to Internal Organs

       4.    ↑ Salivation, Drooling, and Panting Rates

       5.    ↓ Metabolic and Heat Production Rates

       6.    ↓ Heat Loss via Radiant, Conductive, and Convective
               Avenues

       7.    ↑ Dehydration
Heat Stress - Physiological Strain

                                            General
       1.     ↑ Impact Other Stressors

       2.     ↑ Heart and Pulse Rates

       3.     ↑ Hyperventilation
                             A.      ↓   Blood Carbon Dioxide
                             B.      ↓   Blood Bicarbonate
                             C.      ↓   Blood Buffering Capacity
                             D.      ↑   Respiratory Alkalosis

       4.     ↑ Urinary Sodium and Bicarbonate Excretion

       5.     ↓ Hepatic Portal Blood Flow

       6.     ↑ Hepatic Vitamin A Storage

       7.     ↑ General Vitamin E Deficiency
Heat Stress - Physiological Strain

                                     Immune Status

       1.     ↓ Immune Function

       2.     ↑ Susceptibility to Parasitic and Nonparasitic Diseases

       3.     ↑ Mastitis

       4.     ↑ Somatic Cell Count

       5.     ↑ Plasma Antibody - Immunoglobulin Concentration

       6.     ↑ Death
Heat Stress - Physiological Strain

                                       Nutritional Status
       1.    ↓ DMI, Weight Gain or Growth, Condition Score, and Blood
               Glucose Level

       2.    ↑ Energy Requirement for Maintenance

       3.    ↑ Salivation
                A.   ↓   Saliva to Rumen
                B.   ↓   Salivary Bicarbonate Pool for Rumenal Buffering
                C.   ↓   Rumen pH
                D.   ↑   Acidosis

       4.    ↑ Potassium Loss from Skin

       5.    ↑ Dietary Requirements for Potassium and Sodium

       6.    ↑ Urinary Nitrogen Loss

       7.    ↑ Water Intake
Heat Stress - Physiological Strain

                          Nutritional Status - continued
       8.    ↓ Rumination
                  A.    ↓ Gut and Rumen Motility
                  B.    ↓ Gut Passage Rate
                  C.    ↑ Gut Fill
                  D.    ↓ Rumen Volatile Fatty Acid Concentration
                  E.    ↑ Acetate to Propionate Ratio


                                     Milk Production
        1.    ↓ Milk Production

        2.    ↓ Mammary Blood Flow

        3.    ↓ Mammogenesis

        4.    ↓ Lactation Peaks

        5.    ↓ Milk Component Levels
Heat Stress - Physiological Strain

                                     Behavior
       1.    ↓ Grazing Time

       2.    ↑ Lethargy

       3.    ↑ Shadow or Shade Seeking

       4.    ↑ Body Alignment with Solar Radiation

       5.    ↑ Standing Time

       6.    ↑ Crowding Water Trough and Splashing

       7.    ↑ Agitation and Restlessness
Heat Stress - Physiological Strain

                                         Endocrine


       1.    ↓ Hormones Linked to Metabolism – Thyroxine, Somatotropin,
                                                        Cortisol

       2.    ↑ Hormones Linked to Water and Electrolyte Metabolism –
                    Antidiuretic Hormone, Aldosterone


       3.     ↑ Catecholamines – Epinephrine and Norepinephrine

       4.     ↑ Prolactin and ↓ Prolactin Receptor Numbers

       5.    ↑ Leptin

       6.    ↑ Insulin >> ↓ Blood Glucose
Heat Stress - Physiological Strain

                                     Reproductive Status

       1.    ↓ Breeding Efficiency and Conception Rate

       2.    ↑ Fetal and Postnatal Mortalities + ↓ Calf Birth Weight

       3.    ↓ Semen Quality
                A. ↓ Spermatogenesis
                B. ↓ Sperm Motility
                C. ↑ Percent Abnormal and Aged Sperm

       4.    ↓ Estrous Activity
                A. ↓ Estrous Duration
                B. ↓ Heat Detection

       5.    ↓ Uterine Blood Flow
                A. ↓ Placental Weight and Growth + ↑ Retained Placenta
                B. ↓ Gestation Period
                C. ↑ Labor and Delivery Difficulties
Heat Stress - Physiological Strain

                        Reproductive Status - continued

       6.    ↓ Follicular Development
                  A.    ↓ Oocyte quality
                  B.    ↑ Multiple Ovulations and Twinning
                  C.    ↓ Corporea Lutea Size


       7.       Biochemical Changes
                  A.    ↓ Plasma LH
                  B.    ↑ Ketone and NEFA Levels at Calving
                  C.    ↓ Thyroxine During Pregnancy
                  D.    ↑ Plasma Progesterone During Late Gestation
                  E.    ↑ Prostaglandin Synthesis Rate and Level During Early
                          Postpartum Period
CAN WE REDUCE THE PROBLEM
 FROM THE THERMAL STATUS
      PERSPECTIVE?
Influenced by

      Body Surface Area
      Body Coverings                        Influenced by        Sources
      Water Exchange
      Blood Flow                            Calorigenic
                                            Hormones             Food
      Environment:
       Temperature
                                            Production:          Body Reserves
       Wind
       Humidity                              Milk
                                             Meat                Rumen or Cecum
                                             Wool                Fermentation

 Non-Evap.            Evaporative                                Environment
                        Cooling             Muscular
  Cooling
Radiation             Respiration           Activity
                                            Maintenance
Convection            Skin

Conduction
                                                                        Light
             HEAT LOSS                                      HEAT GAIN   Bulbs


Hypothermia                                                 Hyperthermia
                                     Normal
                                Body Temperature
BIG PROBLEM




  METABOLISM

      OR

HEAT PRODUCTION
1 ADULT HUMAN = 1 - 100 WATT
                       LIGHT BULB




                     1 LACTATING DAIRY
                       COW = 16 - 100
                       WATT LIGHT
                       BULBS




BIG BOVINE PROBLEM = HUGE HEAT PRODUCTION
Occurs with reduction in feed intake.
AVENUES

OF HEAT LOSS
Conductive, Convective, and Radiative Exchanges
Require a Temperature Gradient
CONDUCTION
               RADIATION

 CONVECTION


    LESS EFFECTIVE AS AIR
TEMPERATURE APPROACHES SKIN
        TEMPERATURE
EVAPORATIVE

 EXCHANGE
Only Solution is Increase Evaporative Heat Loss
Heat Dissipation (kcal/m/hr)
                                                            Surface Vaporization
                               140
                                                            Non-Evaporative Process
2




                               120                          Respiratory Vaporization

                               100

                                80

                                60

                                40

                                20

                                 0
                                     0     20     40         60           80           100
                                         Ambient Temperature ( oF)
                                                   Redrawn from Yeck and Kibler (1956) and
                                                                    Kibler and Yeck (1959)
BUT
      A CHALLENGE TO
      CHANGE



      ESPECIALLY FOR BEEF
      CATTLE AND GRAZING
      DAIRY COWS
MANY DIFFERENT LEVELS OF SENSITIVITY

      COMPLICATING FACTORS:

      1. Breed

      2. Age

      3. Health

      4. Gender

      5. Geographic Location and
           Climate

      6. Acclimation Duration
IS IT POSSIBLE TO PREDICT ANIMAL
    RESPONSE TO HEAT STRESS?

1. Remove or provide extra care for “sensitive” animals
      A. Change environment
      B. Change animal
            1. Reduce heat production
            2. Increase heat loss

2. Identify heat extremes in advance
      A. Change environment
      B. Change animal
            1. Reduce heat production
            2. Increase heat loss

3. Acclimation Program
AMBIENT
CONDITION

                ANIMAL
   Present



               THERMAL
                STATUS


  ANIMAL
PRODUCTIVITY
AMBIENT
               Extremely difficult
CONDITION
               Why?

               Ambient condition = indirect
   Present



                                   stressor

               Does not account for
                     “Complicating Factors”

               Temperature Humidity Index
  ANIMAL            is an example

PRODUCTIVITY
AMBIENT
 CONDITION

                                    ANIMAL
Improvement
                                   THERMAL
Why?                                STATUS
Account s for
     “Complicating Factors”

Physiological Strain Index is an
      example
AMBIENT
CONDITION

                ANIMAL
   Present



               THERMAL
                STATUS


  ANIMAL
PRODUCTIVITY
Critical
                              Zone ?
Performance or Health


                                           HYPERTHERMIA
                                           WEIGHT LOSS
                                           DYSFUNCTION
                                           DISEASE




                                                  DEATH

                        Stress or Strain
Young’s Modulus of Elasticity = object or substance's
tendency to be deformed elastically (i.e., non-permanently)
when a force is applied to it.

The elastic modulus of an object is defined as the slope of its
stress-strain curve in the elastic deformation region:



         Elasticity = Stress/Strain




                           Thomas Young
“If it were possible to measure quantitatively all
the strains responding to a given stress, we
could devise a type of Young’s Modulus of
Elasticity (stress/strain). The reciprocal of this
(strain/stress) would represent the additive
compliance of animals and might be called an
index of adaptation. This index could be of value
both in determining the degree of adaptation
achieved by an animal after a given period of
exposure to the stress and in determining when
adaptation is complete. It might also be useful in
comparing the degree of adaptation achieved by
different species under similar conditions.“

Melvin Fregly

Symposium Conducted by The National
Academy of Sciences-National Research
Council August, 1966

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Heat Stress Effects - Issues & Questions

  • 1. HEAT STRESS EFFECTS: ISSUES & QUESTIONS DON SPIERS UNIVERSITY OF MISSOURI-COLUMBIA
  • 2. WHAT IS STRESS? (Initial Question)
  • 3. Stress = the environment or stimulus (same for everyone) Strain = the effect or response (different for everyone)
  • 4. “It’s not stress that kills us, it is our reaction to it.”
  • 5. “I cannot, and should not, be cured of my stress but merely taught to enjoy it” Hans Selye, l950
  • 7. Impaired Functions (the short list) 1. Drop in production 2. Increased days open 3. Depressed immune system 4. Decreased fertility
  • 8. THE COST Annual losses in the US due to heat stress equal $1.7 billion. Dairy = $897 million Beef = $369 million
  • 9. PHYSIOLOGICAL CHANGES 1. Thermal Status 2. General Effects 3. Immune Condition 4. Nutritional Status 5. Behavior 6. Endocrine 7. Reproductive Status
  • 10. Heat Stress - Physiological Strain Thermal Status 1. ↑ Core Body Temperature – rumen – tympanic – intraperitoneal A. Total Body Heat Content 2. ↑ Respiration Rate and Respiratory Evaporative Heat Loss 3. ↑ Skin Temperature, Blood Flow, and Sweat Rate A. ↓ Blood Flow to Internal Organs 4. ↑ Salivation, Drooling, and Panting Rates 5. ↓ Metabolic and Heat Production Rates 6. ↓ Heat Loss via Radiant, Conductive, and Convective Avenues 7. ↑ Dehydration
  • 11. Heat Stress - Physiological Strain General 1. ↑ Impact Other Stressors 2. ↑ Heart and Pulse Rates 3. ↑ Hyperventilation A. ↓ Blood Carbon Dioxide B. ↓ Blood Bicarbonate C. ↓ Blood Buffering Capacity D. ↑ Respiratory Alkalosis 4. ↑ Urinary Sodium and Bicarbonate Excretion 5. ↓ Hepatic Portal Blood Flow 6. ↑ Hepatic Vitamin A Storage 7. ↑ General Vitamin E Deficiency
  • 12. Heat Stress - Physiological Strain Immune Status 1. ↓ Immune Function 2. ↑ Susceptibility to Parasitic and Nonparasitic Diseases 3. ↑ Mastitis 4. ↑ Somatic Cell Count 5. ↑ Plasma Antibody - Immunoglobulin Concentration 6. ↑ Death
  • 13. Heat Stress - Physiological Strain Nutritional Status 1. ↓ DMI, Weight Gain or Growth, Condition Score, and Blood Glucose Level 2. ↑ Energy Requirement for Maintenance 3. ↑ Salivation A. ↓ Saliva to Rumen B. ↓ Salivary Bicarbonate Pool for Rumenal Buffering C. ↓ Rumen pH D. ↑ Acidosis 4. ↑ Potassium Loss from Skin 5. ↑ Dietary Requirements for Potassium and Sodium 6. ↑ Urinary Nitrogen Loss 7. ↑ Water Intake
  • 14. Heat Stress - Physiological Strain Nutritional Status - continued 8. ↓ Rumination A. ↓ Gut and Rumen Motility B. ↓ Gut Passage Rate C. ↑ Gut Fill D. ↓ Rumen Volatile Fatty Acid Concentration E. ↑ Acetate to Propionate Ratio Milk Production 1. ↓ Milk Production 2. ↓ Mammary Blood Flow 3. ↓ Mammogenesis 4. ↓ Lactation Peaks 5. ↓ Milk Component Levels
  • 15. Heat Stress - Physiological Strain Behavior 1. ↓ Grazing Time 2. ↑ Lethargy 3. ↑ Shadow or Shade Seeking 4. ↑ Body Alignment with Solar Radiation 5. ↑ Standing Time 6. ↑ Crowding Water Trough and Splashing 7. ↑ Agitation and Restlessness
  • 16. Heat Stress - Physiological Strain Endocrine 1. ↓ Hormones Linked to Metabolism – Thyroxine, Somatotropin, Cortisol 2. ↑ Hormones Linked to Water and Electrolyte Metabolism – Antidiuretic Hormone, Aldosterone 3. ↑ Catecholamines – Epinephrine and Norepinephrine 4. ↑ Prolactin and ↓ Prolactin Receptor Numbers 5. ↑ Leptin 6. ↑ Insulin >> ↓ Blood Glucose
  • 17. Heat Stress - Physiological Strain Reproductive Status 1. ↓ Breeding Efficiency and Conception Rate 2. ↑ Fetal and Postnatal Mortalities + ↓ Calf Birth Weight 3. ↓ Semen Quality A. ↓ Spermatogenesis B. ↓ Sperm Motility C. ↑ Percent Abnormal and Aged Sperm 4. ↓ Estrous Activity A. ↓ Estrous Duration B. ↓ Heat Detection 5. ↓ Uterine Blood Flow A. ↓ Placental Weight and Growth + ↑ Retained Placenta B. ↓ Gestation Period C. ↑ Labor and Delivery Difficulties
  • 18. Heat Stress - Physiological Strain Reproductive Status - continued 6. ↓ Follicular Development A. ↓ Oocyte quality B. ↑ Multiple Ovulations and Twinning C. ↓ Corporea Lutea Size 7. Biochemical Changes A. ↓ Plasma LH B. ↑ Ketone and NEFA Levels at Calving C. ↓ Thyroxine During Pregnancy D. ↑ Plasma Progesterone During Late Gestation E. ↑ Prostaglandin Synthesis Rate and Level During Early Postpartum Period
  • 19. CAN WE REDUCE THE PROBLEM FROM THE THERMAL STATUS PERSPECTIVE?
  • 20. Influenced by Body Surface Area Body Coverings Influenced by Sources Water Exchange Blood Flow Calorigenic Hormones Food Environment: Temperature Production: Body Reserves Wind Humidity Milk Meat Rumen or Cecum Wool Fermentation Non-Evap. Evaporative Environment Cooling Muscular Cooling Radiation Respiration Activity Maintenance Convection Skin Conduction Light HEAT LOSS HEAT GAIN Bulbs Hypothermia Hyperthermia Normal Body Temperature
  • 21. BIG PROBLEM METABOLISM OR HEAT PRODUCTION
  • 22. 1 ADULT HUMAN = 1 - 100 WATT LIGHT BULB 1 LACTATING DAIRY COW = 16 - 100 WATT LIGHT BULBS BIG BOVINE PROBLEM = HUGE HEAT PRODUCTION
  • 23. Occurs with reduction in feed intake.
  • 25. Conductive, Convective, and Radiative Exchanges Require a Temperature Gradient
  • 26. CONDUCTION RADIATION CONVECTION LESS EFFECTIVE AS AIR TEMPERATURE APPROACHES SKIN TEMPERATURE
  • 28. Only Solution is Increase Evaporative Heat Loss
  • 29. Heat Dissipation (kcal/m/hr) Surface Vaporization 140 Non-Evaporative Process 2 120 Respiratory Vaporization 100 80 60 40 20 0 0 20 40 60 80 100 Ambient Temperature ( oF) Redrawn from Yeck and Kibler (1956) and Kibler and Yeck (1959)
  • 30.
  • 31. BUT A CHALLENGE TO CHANGE ESPECIALLY FOR BEEF CATTLE AND GRAZING DAIRY COWS
  • 32. MANY DIFFERENT LEVELS OF SENSITIVITY COMPLICATING FACTORS: 1. Breed 2. Age 3. Health 4. Gender 5. Geographic Location and Climate 6. Acclimation Duration
  • 33. IS IT POSSIBLE TO PREDICT ANIMAL RESPONSE TO HEAT STRESS? 1. Remove or provide extra care for “sensitive” animals A. Change environment B. Change animal 1. Reduce heat production 2. Increase heat loss 2. Identify heat extremes in advance A. Change environment B. Change animal 1. Reduce heat production 2. Increase heat loss 3. Acclimation Program
  • 34. AMBIENT CONDITION ANIMAL Present THERMAL STATUS ANIMAL PRODUCTIVITY
  • 35. AMBIENT Extremely difficult CONDITION Why? Ambient condition = indirect Present stressor Does not account for “Complicating Factors” Temperature Humidity Index ANIMAL is an example PRODUCTIVITY
  • 36. AMBIENT CONDITION ANIMAL Improvement THERMAL Why? STATUS Account s for “Complicating Factors” Physiological Strain Index is an example
  • 37. AMBIENT CONDITION ANIMAL Present THERMAL STATUS ANIMAL PRODUCTIVITY
  • 38. Critical Zone ? Performance or Health HYPERTHERMIA WEIGHT LOSS DYSFUNCTION DISEASE DEATH Stress or Strain
  • 39. Young’s Modulus of Elasticity = object or substance's tendency to be deformed elastically (i.e., non-permanently) when a force is applied to it. The elastic modulus of an object is defined as the slope of its stress-strain curve in the elastic deformation region: Elasticity = Stress/Strain Thomas Young
  • 40. “If it were possible to measure quantitatively all the strains responding to a given stress, we could devise a type of Young’s Modulus of Elasticity (stress/strain). The reciprocal of this (strain/stress) would represent the additive compliance of animals and might be called an index of adaptation. This index could be of value both in determining the degree of adaptation achieved by an animal after a given period of exposure to the stress and in determining when adaptation is complete. It might also be useful in comparing the degree of adaptation achieved by different species under similar conditions.“ Melvin Fregly Symposium Conducted by The National Academy of Sciences-National Research Council August, 1966