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Similar to Greater Washington Infectious Diseases Conference: Schistosomiasis Parasitic Infection
Similar to Greater Washington Infectious Diseases Conference: Schistosomiasis Parasitic Infection (20)
Greater Washington Infectious Diseases Conference: Schistosomiasis Parasitic Infection
- 1. Greater Washington Infectious Diseases Society Conference October 20, 2008 Temujin T. Chavez, MD LCDR MC USN National Capitol Consortium
- 14. Schistosomiasis – Geographic distribution
- 19. Intestinal schistosomiasis – Clinical features Prevalence (%) of morbidity attributable to S. mansoni in two areas of Burundi Area 5-9 10-19 >/=20 All Bloody diarrhea Cohoha Lake 4.1 5.0 1.1 2.2 Rusizi Plain 3.4 2.8 2.0 2.3 Left liver enlargement Cohoha Lake 1.2 6.4 1.0 1.9 Rusizi Plain 1.1 1.6 0.8 0.9 Spleen enlargement Cohoha Lake 0 3.4 0.4 0.9 Rusizi Plain 0.9 1.3 1.8 1.5 Diarrhea Cohoha Lake 5.1 5.7 0.8 2.5 Rusizi Plain 3.1 2.9 1.9 2.0
- 23. Schistosomiasis – Transmission cycle NEJM 2002;346:1212-1220
- 24. Schistosomiasis mansoni – Global disease burden WHO World Health Report 2002
Editor's Notes
- Abd pain lasting for 1 hr prior to spontaneous resolution Calabar swelling=transient swelling a/w Loa Loa Sowda=oncerciasis localized to one limb. A/w prutitis, swollen, darkened skin
- Left with father to Lofa county: mixed jungle savannah. Wologasi Mts on border of Liberia/Guinea
- Colonoscopy performed with notable vascular pattern of rectum. Hyperemia and puntuate hemorrhage. Mucosal biopsies taken along with biopsy of 8 mm pedunculated polyp in ascending colon
- (40x)Bx of submucosa showed parasitic egg c/w schistosomiasis. Granulomatous inflammation and prominent eosinophilic infiltrate? Hematoxylin and eosin stain with magnification 100x Rectum bx (15 Feb 08): -chrnoic colitis, -shistosoma mansoni eggs ident in mucosa, -no dysplasia identified
- 100x: visualization of rectum lamina propria. Lymphocytic and monocytic invasion. Mild degree of inflammation. Acute pathology. No histopathologic evidence of granulomatous formation.
- 50-60um in length. Viable miracidia survive for 2-3 weeks.
- S. Mansoni much of sub saharan afrcia, northeast brazil, suriname, venezuela the caribbean, lower and middle egypt, the arabic peninsula S. haematobium-SSA, nile valley in egypt and sudan, the maghreb, the arabian peninsula S. japonicum-along the central lakes and river Yankgtze, Mindanao, Leyte, and Phillipines S. mekongi-central mekong basin in laos and cambodia S. Interclatum pockets in w. and central africa
- DALY=one lost year of healthy life Schistosomiasis was 3 rd larges loss of tropical disease worldwide Mortality due to schistosomiasis by direct mortality and not due to renal failure, bladder cancer, cirrhosis or colon cancer
- Epg=eggs per gram Diarrhea/bloody diarrhea/abd pain – 2 episodes lasting one day or more in past 2 mos
- 35% of bloody diarrhea due to S. mansoni. For diarrhea, 9% attributable to S. mansoni Prevalence of abd pain high 82% cohoha lake nd 72% rusizi plain
- 50-60um in length. Viable miracidia survive for 2-3 weeks.
- GBD: from epidemiologic model. 2-Prevalence=extrapolation from historical prevalence data. 3-Morbidityand mortality estimates that quantified prevalence of infection and prevalence of selected morbid outcomes.
- (oxadiazole—targets enzyme TGR) identified as effective against S. mansoni