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TAD Challenges and future prospective


              TAD control
( Strengthening of Veterinary Services)
              Presented
                       By
              Prof. Hassan Aidaros
   Prof. of Hygiene and Preventive Medicine
OIE Representative for Egypt (h.aidaros@oie.int)
                        2
• The increased movements of livestock , animal products and human
  play an important role in spreading Animal diseases.
• A remarkable progress in trade in livestock and animal products
  through the last few decades.
• A plane can transport human or animal products ( including
  pathogens)for several thousands kilometers in few hours
• The inter-relationships between agents causing disease, animal husbandry, human behavior and
  the environment are numerous and complex
   So the management of disease requires a holistic approach.

• The “One health” approach is appropriate to address zoonoses as well as livestock diseases such
  as HPAI, FMD and other TADs which can have severe impacts on:

  - people livelihood,
  - access to local and national markets,
  - wildlife conservation,
  - Income of producers and availability of work
  - Food for the population
• The main responsibility for the control and prevention of diseases of
  livestock rests with animal health systems, which are underpinned by
  Veterinary Services (VS)
• The VS is recognized as a global public goods
VS is a global public goods
• TAD control, based on sound strategies and tools,
  generates “global public goods”.
   Where the disease is better controlled, the benefits will
  be shared across the society of the country as:
  - Consumers will benefit from greater stability and
  availability of livestock products,
 - Livestock owners will have fewer losses and greater
  market opportunities and
 - People working and running businesses in the livestock
  sector will have more reliable source of product of better
  quality.
VS is a global public goods
• For countries that share borders and trading systems there will
  be benefits for both.

• In general it is important to recognize that these benefits will
  also be available for future generations.

• Conversely, a country that fails to control TADs may negatively
  impact on its neighbors and possibly also those countries with
  which it trades.

• That is the “global public goods”.
• FAO and OIE have embarked, under the umbrella of
  the Global Framework for the Progressive Control of
  Transboundary Animal Diseases (GF-TADs), on a
  Global Strategy and Global Action Plan for FMD
  control, with particular emphasis on regions of the
  world where the disease is endemic.
Global Surveillance




Endemic

Intermediate, sporadic


Free with vaccination

Countries with multiples zones:
FMD-free, free with vaccination or not free

Free. Virus present in game parks


Free
Visualization of Regional Virus Pools
        as an Aid to Global Control
Divides the Globe into 7 pools each with


• Multiple serotypes but topotypes mainly confined to that
 pool
• Each pool may need tailored vaccines and strategies
The conjectured status of FMD showing approximate
         distribution of regional virus pools.



                                      Pool 3
                                      O, A, Asia 1




                                                     Pool 1
                                                     O, A, Asia 1


                               Pool 2
                               O, A, Asia 1
The conjectured status of FMD showing approximate
         distribution of regional virus pools.




         Pool 5
         O, A, SAT 1, 2




                     Pool 4
                     A, O, SAT 1, 2, 3
                                         Pool 6
                                         SAT 1, 2, 3
The conjectured status of FMD showing approximate
         distribution of regional virus pools.




Pool 7
O, A
WRLFMD Regional Analysis- 2012
                                  ®




                   What Else?

                                                                Pool 3   Pool 3
                                                        O, A, Asia 1 &O, A, Asia 1
                                                                      SAT 2


                         Pool 5
                     No reports in 2012
                                                                                     Pool 1
                                                                                     O&A
       Pool 7
No reports in 2012                                               Pool 2
                                                                 O, A, Asia 1

                                      Pool 4
                                      A, O, SAT 1 & 2
                                                         Pool 6
                                                         SAT 1 & 2
Egypt- Recent FMD Outbreaks

Egypt has at least 3 serotypes of FMDV
and a number of topotypes

1.   O/ME-SA/Egy-72 (2006-2009)
2.   O/ME-SA/PanAsia 2 (Egy-09) (2009 & 2011
3.   A/Africa/G-VII (Ken-05) (2006 & 2009)
4.   A/Asia/Iran-05 (Bar-08) (2010-2011)
5.   A/Africa/G-IV (ISM-12) (2012)
6.   SAT2/VII/Alx-12 (2012)
7.   SAT2/VII/Ghb-12 (2012)
FMD Outbreaks 2012
                           Vaccination against SAT 2 in Egypt
August 2012

Vaccination with monovalent SAT2 – 1st round with locally produced vaccine
Total= 827,954 in 21 governorates .                                4 million cattle
cattle 431,568                                                     3 million buffalo
Buffaloes 211,352
sheep 159,398
goat 25,636

2nd round vaccination with monovalent locally produced SAT2 vaccine =              148,741
cattle 114.439
buffaloes 31,946
sheep 1,289
goat 1,067

Information provided by Dr Soheir Hassan Abd El Kader
Under Secretary of centeral adminstration of preventive medicine
General Organization for Veterinary Services
Ministry of Agriculture
Cairo, Egypt
Current FMD Threat Analysis: Vaccine matching 2012
                             Serotype O vaccine matching
Country         Serotype   Topotype   Lineage/    Sub
of Origin                             strain      Lineage   O 3039 O 4625 O Manisa O PA2

Afghanistan     O          ME-SA      PanAsia-2   ANT-10
Bahrain         O          ME-SA      PanAsia-2   ANT-10
Congo           O          ME-SA      PanAsia     -
Egypt           O          ME-SA      PanAsia-2   -
Ethiopia        O          EA-3       -           -
Iran            O          ME-SA      PanAsia-2   ANT-10
                O          ME-SA      PanAsia-2   FAR-09
Israel          O          ME-SA      PanAsia-2   ANT-10
Japan           O          SEA        Mya 98      -
Kenya           O          EA-2       -           -
Kuwait          O          ME-SA      PanAsia-2   ANT-10
Libya           O          ME-SA      PanAsia-2   ANT-10
                O          EA-3       -           -
Malaysia        O          SEA        Mya-98      -
Kingdom Saudi   O          ME-SA      PanAsia-2   ANT-10
Arabia
Sudan           O          EA-3       -           -
Thailand        O          SEA        Mya-98      -
                O          ME-SA      PanAsia     -
Turkey          O          ME-SA      PanAsia-2   ANT-10
UAE             O          ME-SA      PanAsia-2   ANT-10
Vietnam         O          ME-SA      PanAsia     -
Current FMD Threat Analysis: Vaccine matching 2012
                        Pool 4 Eastern Africa

                              Serotype A vaccine matching

Country      Serotype    Topotype   Lineage/       Sub
of Origin                           strain         Lineage   A       A       A     A   A
                                                             Eri   Saudi   Iran   Tur MAY
                                                             98     95 A22 05     06   97


Congo        A           Africa     G-I            -
Egypt        A           Africa     G-IV           -
             A           Asia       Iran-05        BAR-08
Sudan        A           Africa     G-IV           -




                                              Good match
                                              Some matches
                                              No match
Current FMD Threat Analysis: Vaccine matching 2012

                                SAT Serotypes Vaccine Matching

                 Country     Serotype       Topotype
                 of Origin                             SAT 1
Pool 4                                                 Rho
Eastern Africa   Kenya       SAT 1          I (NWZ)



                                                                 SAT 2 Zim SAT 2 Eri

                 Bahrain     SAT 2          IV
                 Egypt       SAT 2          VII
Pool 3           Kenya       SAT 2          IV
Eur-Asia         Libya       SAT 2          VII
Pool 4           PAT         SAT 2          VII
Eastern Africa   Sudan       SAT 2          VII
                 Tanzania    SAT 2          IV


                                     Good match
                                     Some matches
                                     No match
• FMD is one of the most contagious animal diseases and
  internationally the most important TAD.

• In countries where FMD is endemic the disease is often
  under reported, even though farmers have been shown to
  suffer serious economic losses.

• Many developing countries are poorly equipped to deal
  effectively with livestock diseases, including FMD, and so
  it continues to negatively affect food security and
  economic development.
THE PROGRESSIVE CONTROL PATHWAY
         FOR FMD CONTROL
           (FMD-PCP)
PCP-FMD
• The PCP-FMD is a set of FMD control activity stages (Figure 1) that, if
  implemented, should enable countries to progressively increase the level of
  FMD control to the point where an application for OIE-endorsement of a
  national control programme vaccination (in an advanced phase of Stage 3)
  or official freedom from FMD with or without vaccination (end of Stages
  4 and 5, respectively) may be successful and the status sustainable.
The PCP approach is based on the following
principles:

  1) active monitoring for FMDV circulation and
understanding the epidemiology of FMD are the
foundation of a control program, and therefore
activities to meet these requirements are
common in all stages.
The monitoring of outcomes (indicators of control
effectiveness), within a national FMD
management system, is included at the higher
stages;
2) activities in each PCP stage are appropriate to the
required reduction in virus circulation and mitigation of
disease risk to be achieved;
  3) activities and their impacts are measurable in
each Stage, comparable between countries, and
generate information and potential benefits to national
as well as international stakeholders;
  4) the optimization of resource use for FMD control is
achieved through the targeting of measures to the
husbandry systems and critical risk points where the
impact on disease control and/or virus circulation will be
greatest.
Strengthening Veterinary Services

• VS are an essential component of the animal health system that
  protects animal health and safeguards animal production;

  To function effectively, VS require:
    - Appropriate infrastructure,
     - Trained and effective personnel
     - Sufficient operating budgets to perform their disease
       mitigation activities.

 Unfortunately, in many developing countries, the VS infrastructure is
 often of insufficient quality and the operating budget inadequate.
With globalisation and the growth of international
trade, the responsibility of VS extends beyond
national borders, in particular in regard to trade in
livestock and animal products. Importers and
consumers desire healthy livestock and safe animal
products and this brings into consideration the quality
and credibility of VS.
• PVS pathway: evaluation of the veterinary services
    The OIE tool for the Evaluation of Performance of
  Veterinary Services (OIE PVS Tool) is an objective,
  qualitative mechanism for assessing the quality of VS
  that creates a basis for a Gap Analysis and the
  development of an investment plan to seek the
  necessary funds to redress these weaknesses.
Key Words:
Critical competencies

      I- Human Physical and Financial Resources:

I.2.A. Professional competencies of veterinarians
 I.2.B. Competencies of veterinary para-professionals
 I.3. Continuing education
 I.4. Technical independence
 I.5. Stability of structures and sustainability of policies
 I.6.A. Internal coordination (chain of command)
 I.6.B. External coordination
I.7. Physical resources
1.8. Funding
1.9. Contingency and compensatory funding
1.10. Capability to invest and develop
II- Technical Authority and Capability:

II.1.Veterinary laboratory diagnosis
II.2.Laboratory quality assurance
II.3.Risk analysis
II.4.Quarantine and border security
II.5.Epidemiological surveillance
II.6.Early detection and emergency response
II.7.Disease prevention control and eradication
II.8.Veterinary pubic health and food safety
II.9.Veterinary medicines and veterinary biologicals
II.10.Residue testing
II.11.Emergency issues
II.12.Technical innovation
III- Interaction with stakeholders:
III.1.Communications
III.2.Consultation with stakeholders
III.3.Official representation
III.4.Accredetation/authorization/delegation
III.5.Veterinary statutory body
III.6. Participation of producers and other stakeholders
   in joint programmes
IV-Access to markets:

IV.1.Preparation of legislation and regulations, and its
  implementation
IV.2.Stakeholder compliance with legislation and regulations
IV.3.International harmonization
IV.4.International certification
IV.5.Equivalence and other types of sanitary agreements
IV.6.Traceability
IV.7.Transparency
IV.8.Zoning
IV.9.Compatmentalisation
Thank you for your
          kind attention

               Prof. Hassan Aidaros
    Prof. of Hygiene and Preventive Medicine
OIE Representative for Egypt (h.aidaros@oie.com)
                       34

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TAD Challenges and future prospective

  • 1. TAD Challenges and future prospective TAD control ( Strengthening of Veterinary Services) Presented By Prof. Hassan Aidaros Prof. of Hygiene and Preventive Medicine OIE Representative for Egypt (h.aidaros@oie.int) 2
  • 2. • The increased movements of livestock , animal products and human play an important role in spreading Animal diseases. • A remarkable progress in trade in livestock and animal products through the last few decades. • A plane can transport human or animal products ( including pathogens)for several thousands kilometers in few hours
  • 3. • The inter-relationships between agents causing disease, animal husbandry, human behavior and the environment are numerous and complex So the management of disease requires a holistic approach. • The “One health” approach is appropriate to address zoonoses as well as livestock diseases such as HPAI, FMD and other TADs which can have severe impacts on: - people livelihood, - access to local and national markets, - wildlife conservation, - Income of producers and availability of work - Food for the population
  • 4. • The main responsibility for the control and prevention of diseases of livestock rests with animal health systems, which are underpinned by Veterinary Services (VS) • The VS is recognized as a global public goods
  • 5. VS is a global public goods • TAD control, based on sound strategies and tools, generates “global public goods”. Where the disease is better controlled, the benefits will be shared across the society of the country as: - Consumers will benefit from greater stability and availability of livestock products, - Livestock owners will have fewer losses and greater market opportunities and - People working and running businesses in the livestock sector will have more reliable source of product of better quality.
  • 6. VS is a global public goods • For countries that share borders and trading systems there will be benefits for both. • In general it is important to recognize that these benefits will also be available for future generations. • Conversely, a country that fails to control TADs may negatively impact on its neighbors and possibly also those countries with which it trades. • That is the “global public goods”.
  • 7. • FAO and OIE have embarked, under the umbrella of the Global Framework for the Progressive Control of Transboundary Animal Diseases (GF-TADs), on a Global Strategy and Global Action Plan for FMD control, with particular emphasis on regions of the world where the disease is endemic.
  • 8. Global Surveillance Endemic Intermediate, sporadic Free with vaccination Countries with multiples zones: FMD-free, free with vaccination or not free Free. Virus present in game parks Free
  • 9. Visualization of Regional Virus Pools as an Aid to Global Control Divides the Globe into 7 pools each with • Multiple serotypes but topotypes mainly confined to that pool • Each pool may need tailored vaccines and strategies
  • 10. The conjectured status of FMD showing approximate distribution of regional virus pools. Pool 3 O, A, Asia 1 Pool 1 O, A, Asia 1 Pool 2 O, A, Asia 1
  • 11. The conjectured status of FMD showing approximate distribution of regional virus pools. Pool 5 O, A, SAT 1, 2 Pool 4 A, O, SAT 1, 2, 3 Pool 6 SAT 1, 2, 3
  • 12. The conjectured status of FMD showing approximate distribution of regional virus pools. Pool 7 O, A
  • 13. WRLFMD Regional Analysis- 2012 ® What Else? Pool 3 Pool 3 O, A, Asia 1 &O, A, Asia 1 SAT 2 Pool 5 No reports in 2012 Pool 1 O&A Pool 7 No reports in 2012 Pool 2 O, A, Asia 1 Pool 4 A, O, SAT 1 & 2 Pool 6 SAT 1 & 2
  • 14. Egypt- Recent FMD Outbreaks Egypt has at least 3 serotypes of FMDV and a number of topotypes 1. O/ME-SA/Egy-72 (2006-2009) 2. O/ME-SA/PanAsia 2 (Egy-09) (2009 & 2011 3. A/Africa/G-VII (Ken-05) (2006 & 2009) 4. A/Asia/Iran-05 (Bar-08) (2010-2011) 5. A/Africa/G-IV (ISM-12) (2012) 6. SAT2/VII/Alx-12 (2012) 7. SAT2/VII/Ghb-12 (2012)
  • 15. FMD Outbreaks 2012 Vaccination against SAT 2 in Egypt August 2012 Vaccination with monovalent SAT2 – 1st round with locally produced vaccine Total= 827,954 in 21 governorates . 4 million cattle cattle 431,568 3 million buffalo Buffaloes 211,352 sheep 159,398 goat 25,636 2nd round vaccination with monovalent locally produced SAT2 vaccine = 148,741 cattle 114.439 buffaloes 31,946 sheep 1,289 goat 1,067 Information provided by Dr Soheir Hassan Abd El Kader Under Secretary of centeral adminstration of preventive medicine General Organization for Veterinary Services Ministry of Agriculture Cairo, Egypt
  • 16. Current FMD Threat Analysis: Vaccine matching 2012 Serotype O vaccine matching Country Serotype Topotype Lineage/ Sub of Origin strain Lineage O 3039 O 4625 O Manisa O PA2 Afghanistan O ME-SA PanAsia-2 ANT-10 Bahrain O ME-SA PanAsia-2 ANT-10 Congo O ME-SA PanAsia - Egypt O ME-SA PanAsia-2 - Ethiopia O EA-3 - - Iran O ME-SA PanAsia-2 ANT-10 O ME-SA PanAsia-2 FAR-09 Israel O ME-SA PanAsia-2 ANT-10 Japan O SEA Mya 98 - Kenya O EA-2 - - Kuwait O ME-SA PanAsia-2 ANT-10 Libya O ME-SA PanAsia-2 ANT-10 O EA-3 - - Malaysia O SEA Mya-98 - Kingdom Saudi O ME-SA PanAsia-2 ANT-10 Arabia Sudan O EA-3 - - Thailand O SEA Mya-98 - O ME-SA PanAsia - Turkey O ME-SA PanAsia-2 ANT-10 UAE O ME-SA PanAsia-2 ANT-10 Vietnam O ME-SA PanAsia -
  • 17. Current FMD Threat Analysis: Vaccine matching 2012 Pool 4 Eastern Africa Serotype A vaccine matching Country Serotype Topotype Lineage/ Sub of Origin strain Lineage A A A A A Eri Saudi Iran Tur MAY 98 95 A22 05 06 97 Congo A Africa G-I - Egypt A Africa G-IV - A Asia Iran-05 BAR-08 Sudan A Africa G-IV - Good match Some matches No match
  • 18. Current FMD Threat Analysis: Vaccine matching 2012 SAT Serotypes Vaccine Matching Country Serotype Topotype of Origin SAT 1 Pool 4 Rho Eastern Africa Kenya SAT 1 I (NWZ) SAT 2 Zim SAT 2 Eri Bahrain SAT 2 IV Egypt SAT 2 VII Pool 3 Kenya SAT 2 IV Eur-Asia Libya SAT 2 VII Pool 4 PAT SAT 2 VII Eastern Africa Sudan SAT 2 VII Tanzania SAT 2 IV Good match Some matches No match
  • 19. • FMD is one of the most contagious animal diseases and internationally the most important TAD. • In countries where FMD is endemic the disease is often under reported, even though farmers have been shown to suffer serious economic losses. • Many developing countries are poorly equipped to deal effectively with livestock diseases, including FMD, and so it continues to negatively affect food security and economic development.
  • 20. THE PROGRESSIVE CONTROL PATHWAY FOR FMD CONTROL (FMD-PCP)
  • 21. PCP-FMD • The PCP-FMD is a set of FMD control activity stages (Figure 1) that, if implemented, should enable countries to progressively increase the level of FMD control to the point where an application for OIE-endorsement of a national control programme vaccination (in an advanced phase of Stage 3) or official freedom from FMD with or without vaccination (end of Stages 4 and 5, respectively) may be successful and the status sustainable.
  • 22.
  • 23. The PCP approach is based on the following principles: 1) active monitoring for FMDV circulation and understanding the epidemiology of FMD are the foundation of a control program, and therefore activities to meet these requirements are common in all stages. The monitoring of outcomes (indicators of control effectiveness), within a national FMD management system, is included at the higher stages;
  • 24. 2) activities in each PCP stage are appropriate to the required reduction in virus circulation and mitigation of disease risk to be achieved; 3) activities and their impacts are measurable in each Stage, comparable between countries, and generate information and potential benefits to national as well as international stakeholders; 4) the optimization of resource use for FMD control is achieved through the targeting of measures to the husbandry systems and critical risk points where the impact on disease control and/or virus circulation will be greatest.
  • 25. Strengthening Veterinary Services • VS are an essential component of the animal health system that protects animal health and safeguards animal production; To function effectively, VS require: - Appropriate infrastructure, - Trained and effective personnel - Sufficient operating budgets to perform their disease mitigation activities. Unfortunately, in many developing countries, the VS infrastructure is often of insufficient quality and the operating budget inadequate.
  • 26. With globalisation and the growth of international trade, the responsibility of VS extends beyond national borders, in particular in regard to trade in livestock and animal products. Importers and consumers desire healthy livestock and safe animal products and this brings into consideration the quality and credibility of VS.
  • 27. • PVS pathway: evaluation of the veterinary services The OIE tool for the Evaluation of Performance of Veterinary Services (OIE PVS Tool) is an objective, qualitative mechanism for assessing the quality of VS that creates a basis for a Gap Analysis and the development of an investment plan to seek the necessary funds to redress these weaknesses.
  • 29. Critical competencies I- Human Physical and Financial Resources: I.2.A. Professional competencies of veterinarians I.2.B. Competencies of veterinary para-professionals I.3. Continuing education I.4. Technical independence I.5. Stability of structures and sustainability of policies I.6.A. Internal coordination (chain of command) I.6.B. External coordination I.7. Physical resources 1.8. Funding 1.9. Contingency and compensatory funding 1.10. Capability to invest and develop
  • 30. II- Technical Authority and Capability: II.1.Veterinary laboratory diagnosis II.2.Laboratory quality assurance II.3.Risk analysis II.4.Quarantine and border security II.5.Epidemiological surveillance II.6.Early detection and emergency response II.7.Disease prevention control and eradication II.8.Veterinary pubic health and food safety II.9.Veterinary medicines and veterinary biologicals II.10.Residue testing II.11.Emergency issues II.12.Technical innovation
  • 31. III- Interaction with stakeholders: III.1.Communications III.2.Consultation with stakeholders III.3.Official representation III.4.Accredetation/authorization/delegation III.5.Veterinary statutory body III.6. Participation of producers and other stakeholders in joint programmes
  • 32. IV-Access to markets: IV.1.Preparation of legislation and regulations, and its implementation IV.2.Stakeholder compliance with legislation and regulations IV.3.International harmonization IV.4.International certification IV.5.Equivalence and other types of sanitary agreements IV.6.Traceability IV.7.Transparency IV.8.Zoning IV.9.Compatmentalisation
  • 33. Thank you for your kind attention Prof. Hassan Aidaros Prof. of Hygiene and Preventive Medicine OIE Representative for Egypt (h.aidaros@oie.com) 34