SlideShare uma empresa Scribd logo
1 de 17
Antihistaminics
Histamine
• physiologically active amine C5H9N3
• plant and animal tissue
• Released from mast cells as part of an allergic
reaction (IgE / PG / LT / TNF-A / SP/ NKA
Complement-mediated)
-Gastric Secretion
-Capillary Dilatation
-Bronchoconstriction
-Hypotension Imidazoline
ring and amine gp
Synthesis
• Decarboxylation of AA Histidine by Histidine
decarboxylase
• Mast cells and basophils
Mechanism of Action
• Combining with specific cellular receptors on
cells viz H1-H4 ; Leucocyte diapedesis 
Neutrophil Chemotaxis  Mast Cell
Degranulation
• Primarily H1-mediated in Lewis’ Triple
Response / UV
• H2-H4 blockers / Atypical Antihistaminics
found largely ineffective
Type Location Function
H1 Found on smooth muscles,
endothelium, and central
nervous system tissue
Causes vasodilation, bronchoconstriction
bronchial smooth muscle contraction, separation
of endothelial cells (responsible for hives),
and pain and itching due to insect stings; the
primary receptors involved in allergic rhinitis
symptoms and motion sickness; sleep regulation.
H2 Located on parietal cells Primarily stimulate gastric acid secretion
And we use antiacidic drugs for this receptor
H3 Found on central nervous
system and to a lesser
extent peripheral nervous
system tissue
Decreased neurotransmitter release:
histamine, acetylcholine, norepinephrine,
serotonin
H4 Found primarily in
the basophils and in
the bone marrow. It is also
found onthymus, small
intestine, spleen, andcolon.
Plays a role in chemotaxis.
1st
Antihistaminic
• Piperoxan
• Discovered in 1933 by Jeff Forneau and Daniel
Bovent while developing a guinea pig animal
model of anaphylaxis
• They received the Nobel Prize in 1957
Antihistaminics
• Pharmaceutical agents that inhibit the action of
histamine
• blocking its attachment to histamine receptors
(Classic Antihistaminics)
• inhibiting the enzymatic activity of
histidine decarboxylase (atypical antihistaminics)
• The term antihistamine only refers to H1 receptor
antagonists
Classification
H1 Blockers
Traditional Sedatives (esrt 1st
Gen <1981)
Low-Sedation agents (erst 2nd
Gen)
H2 / H3 / H4-receptor Antagonists
Tricyclic Antihistaminics
Histidine Decarboxylase Enzyme-Inhibitors
Mast Cell Degranulation Inhibitors
• a
Traditional Sedative H1 blockers
• a
Low-Sedation H1 Blockers
• aa
H2 Receptor Antagonists
• Parietal Cells – Inhibit Gastric Secretion
• Cimetidine
• Ranitidine
• Nizatidine
• Roxatidine
• Famotidine
• Lafutidine
H3 Receptor Antagonists
• Nootropics / Neuromodulators
• Ciproxifan
• Clobenpropit
• Conessine
H4 Receptor Antagonists
• Immunomodulators
• Thioperamide
• VUF-6002
• JNJ 7777120
Histidine Decarboxylase Inhibitors
• Tritoqualine
• Catechin
Mast Cell Degranulation Inhibitors
• Sodium Cromogylcate
• Nedocromil
• Inhalational Agents ; Ineffective in Cutaneous
Dermatoses
THANK YOU

Mais conteúdo relacionado

Mais procurados (20)

Histamines antihistamines1 adi
Histamines antihistamines1 adiHistamines antihistamines1 adi
Histamines antihistamines1 adi
 
Antihistamines
AntihistaminesAntihistamines
Antihistamines
 
Histamine and antihistamine
Histamine and antihistamineHistamine and antihistamine
Histamine and antihistamine
 
Histamine and its antagonists
Histamine and its antagonistsHistamine and its antagonists
Histamine and its antagonists
 
Histamine and antihistaminics
Histamine and antihistaminicsHistamine and antihistaminics
Histamine and antihistaminics
 
Drugs acting in uterus - stimulant and relaxant
Drugs acting in uterus - stimulant and relaxant Drugs acting in uterus - stimulant and relaxant
Drugs acting in uterus - stimulant and relaxant
 
Histamine and antihistamine drugs
Histamine and antihistamine drugsHistamine and antihistamine drugs
Histamine and antihistamine drugs
 
Histamine and antihistaminic
Histamine and antihistaminicHistamine and antihistaminic
Histamine and antihistaminic
 
Autacoids and its related drugs
Autacoids  and its related drugsAutacoids  and its related drugs
Autacoids and its related drugs
 
3999 histamine anytryuiop[]d antihistamijertyuines
3999 histamine anytryuiop[]d antihistamijertyuines3999 histamine anytryuiop[]d antihistamijertyuines
3999 histamine anytryuiop[]d antihistamijertyuines
 
Histamine
HistamineHistamine
Histamine
 
Autacoids ,histamine and antihistaminic
Autacoids ,histamine and antihistaminic Autacoids ,histamine and antihistaminic
Autacoids ,histamine and antihistaminic
 
Seminar on histamine
Seminar on histamineSeminar on histamine
Seminar on histamine
 
Histamine as a cns neurotransmitter
Histamine as a cns neurotransmitterHistamine as a cns neurotransmitter
Histamine as a cns neurotransmitter
 
Autacoid1
Autacoid1Autacoid1
Autacoid1
 
Histamine and antihistamin
Histamine and antihistaminHistamine and antihistamin
Histamine and antihistamin
 
Histamine and histamine
Histamine and histamine Histamine and histamine
Histamine and histamine
 
histamine
histaminehistamine
histamine
 
Antihistamines & antiallergics
Antihistamines & antiallergicsAntihistamines & antiallergics
Antihistamines & antiallergics
 
Autacoids
AutacoidsAutacoids
Autacoids
 

Destaque

Respiratory System Pharmacology
Respiratory System PharmacologyRespiratory System Pharmacology
Respiratory System Pharmacologyowhyte
 
Histamine and serotonin ppt by srota dawn
Histamine and serotonin ppt by srota dawnHistamine and serotonin ppt by srota dawn
Histamine and serotonin ppt by srota dawnSrota Dawn
 
Drugs used in peptic ulcer
Drugs used in peptic ulcerDrugs used in peptic ulcer
Drugs used in peptic ulcerAmeer Azeez
 
21.drugs used in peptic ulcer
21.drugs used in peptic ulcer21.drugs used in peptic ulcer
21.drugs used in peptic ulcerDr.Manish Kumar
 
Drugs used in peptic ulcer
Drugs used in peptic ulcer Drugs used in peptic ulcer
Drugs used in peptic ulcer Madan Sigdel
 
Gi drugs outline
Gi drugs  outlineGi drugs  outline
Gi drugs outlineraj kumar
 
Drugs for Peptic Ulcer
Drugs for Peptic UlcerDrugs for Peptic Ulcer
Drugs for Peptic UlcerDr Vinay Gupta
 
ICANN 53 비즈니스
ICANN 53 비즈니스ICANN 53 비즈니스
ICANN 53 비즈니스ICANN
 
اجتماع ICANN 53 ملخص الأعمال
اجتماع ICANN 53 ملخص الأعمالاجتماع ICANN 53 ملخص الأعمال
اجتماع ICANN 53 ملخص الأعمالICANN
 
ICANN 50 Business Digest
ICANN 50 Business DigestICANN 50 Business Digest
ICANN 50 Business DigestICANN
 
Check out our top 5 hostels in Milan for the Expo 2015!
Check out our top 5 hostels in Milan for the Expo 2015!Check out our top 5 hostels in Milan for the Expo 2015!
Check out our top 5 hostels in Milan for the Expo 2015!HostelsClub.com
 
ICANN54 商业文摘
ICANN54 商业文摘 ICANN54 商业文摘
ICANN54 商业文摘 ICANN
 

Destaque (20)

Antihistaminics
AntihistaminicsAntihistaminics
Antihistaminics
 
Histamine & antihistaminics
Histamine & antihistaminicsHistamine & antihistaminics
Histamine & antihistaminics
 
Respiratory System Pharmacology
Respiratory System PharmacologyRespiratory System Pharmacology
Respiratory System Pharmacology
 
Histamine and serotonin ppt by srota dawn
Histamine and serotonin ppt by srota dawnHistamine and serotonin ppt by srota dawn
Histamine and serotonin ppt by srota dawn
 
Drugs used in peptic ulcer
Drugs used in peptic ulcerDrugs used in peptic ulcer
Drugs used in peptic ulcer
 
21.drugs used in peptic ulcer
21.drugs used in peptic ulcer21.drugs used in peptic ulcer
21.drugs used in peptic ulcer
 
Aa 2
Aa 2Aa 2
Aa 2
 
Antihistaminics
AntihistaminicsAntihistaminics
Antihistaminics
 
Drugs used in peptic ulcer
Drugs used in peptic ulcer Drugs used in peptic ulcer
Drugs used in peptic ulcer
 
Gi drugs outline
Gi drugs  outlineGi drugs  outline
Gi drugs outline
 
Drugs for Peptic Ulcer
Drugs for Peptic UlcerDrugs for Peptic Ulcer
Drugs for Peptic Ulcer
 
Opening Day Photo
Opening Day PhotoOpening Day Photo
Opening Day Photo
 
ICANN 53 비즈니스
ICANN 53 비즈니스ICANN 53 비즈니스
ICANN 53 비즈니스
 
اجتماع ICANN 53 ملخص الأعمال
اجتماع ICANN 53 ملخص الأعمالاجتماع ICANN 53 ملخص الأعمال
اجتماع ICANN 53 ملخص الأعمال
 
Art 1 syllabus
Art 1 syllabusArt 1 syllabus
Art 1 syllabus
 
ICANN 50 Business Digest
ICANN 50 Business DigestICANN 50 Business Digest
ICANN 50 Business Digest
 
Check out our top 5 hostels in Milan for the Expo 2015!
Check out our top 5 hostels in Milan for the Expo 2015!Check out our top 5 hostels in Milan for the Expo 2015!
Check out our top 5 hostels in Milan for the Expo 2015!
 
Dili master plan
Dili master planDili master plan
Dili master plan
 
Empathy map donna
Empathy map donnaEmpathy map donna
Empathy map donna
 
ICANN54 商业文摘
ICANN54 商业文摘 ICANN54 商业文摘
ICANN54 商业文摘
 

Semelhante a Antihistaminics

antihistamine presentation-khall.ppt
antihistamine presentation-khall.pptantihistamine presentation-khall.ppt
antihistamine presentation-khall.pptMishiSoza
 
Antihistamine
AntihistamineAntihistamine
Antihistaminemizan00
 
histamineautocoids-181208055453.pdf
histamineautocoids-181208055453.pdfhistamineautocoids-181208055453.pdf
histamineautocoids-181208055453.pdfRinkusingh41606
 
Histamine(autocoids)
Histamine(autocoids)Histamine(autocoids)
Histamine(autocoids)ArunKumar6417
 
Histaminic Pharmacology; clinical approach toward patients
Histaminic Pharmacology; clinical approach toward patients Histaminic Pharmacology; clinical approach toward patients
Histaminic Pharmacology; clinical approach toward patients Dr. Rupendra Bharti
 
7.a. histamine & antihistaminics
7.a. histamine & antihistaminics7.a. histamine & antihistaminics
7.a. histamine & antihistaminicsIAU Dent
 
Autacoids BY DR mukesh.pptx
Autacoids BY DR mukesh.pptxAutacoids BY DR mukesh.pptx
Autacoids BY DR mukesh.pptxShweta Gupta
 
histamin (1).pptx
histamin (1).pptxhistamin (1).pptx
histamin (1).pptxmyLord3
 
7.AUTOCOIDS .pptx
7.AUTOCOIDS .pptx7.AUTOCOIDS .pptx
7.AUTOCOIDS .pptxHamda72
 
Med chem lecture on Antihistaminicdrugs
Med chem lecture on AntihistaminicdrugsMed chem lecture on Antihistaminicdrugs
Med chem lecture on Antihistaminicdrugssagar joshi
 
Autacoids - pharmacological actions and drugs related to them.
Autacoids - pharmacological actions and drugs related to them. Autacoids - pharmacological actions and drugs related to them.
Autacoids - pharmacological actions and drugs related to them. SIVASWAROOP YARASI
 
PHARMACOLOGY (HISTAMINE ITS ANTAGONISTS) pptx
PHARMACOLOGY (HISTAMINE  ITS ANTAGONISTS) pptxPHARMACOLOGY (HISTAMINE  ITS ANTAGONISTS) pptx
PHARMACOLOGY (HISTAMINE ITS ANTAGONISTS) pptxIdenyiDanielEwaEde
 

Semelhante a Antihistaminics (20)

antihistamine presentation-khall.ppt
antihistamine presentation-khall.pptantihistamine presentation-khall.ppt
antihistamine presentation-khall.ppt
 
Antihistamine
AntihistamineAntihistamine
Antihistamine
 
histamineautocoids-181208055453.pdf
histamineautocoids-181208055453.pdfhistamineautocoids-181208055453.pdf
histamineautocoids-181208055453.pdf
 
Histamine(autocoids)
Histamine(autocoids)Histamine(autocoids)
Histamine(autocoids)
 
Histaminic Pharmacology; clinical approach toward patients
Histaminic Pharmacology; clinical approach toward patients Histaminic Pharmacology; clinical approach toward patients
Histaminic Pharmacology; clinical approach toward patients
 
7.a. histamine & antihistaminics
7.a. histamine & antihistaminics7.a. histamine & antihistaminics
7.a. histamine & antihistaminics
 
Antihistamines
AntihistaminesAntihistamines
Antihistamines
 
Antihistamines
Antihistamines Antihistamines
Antihistamines
 
Histamines and Antihistamines
Histamines and AntihistaminesHistamines and Antihistamines
Histamines and Antihistamines
 
histamine seminar.pdf
histamine seminar.pdfhistamine seminar.pdf
histamine seminar.pdf
 
autocoids.pptx
autocoids.pptxautocoids.pptx
autocoids.pptx
 
Antihistamine
Antihistamine Antihistamine
Antihistamine
 
Autacoids BY DR mukesh.pptx
Autacoids BY DR mukesh.pptxAutacoids BY DR mukesh.pptx
Autacoids BY DR mukesh.pptx
 
histamin (1).pptx
histamin (1).pptxhistamin (1).pptx
histamin (1).pptx
 
7.AUTOCOIDS .pptx
7.AUTOCOIDS .pptx7.AUTOCOIDS .pptx
7.AUTOCOIDS .pptx
 
Med chem lecture on Antihistaminicdrugs
Med chem lecture on AntihistaminicdrugsMed chem lecture on Antihistaminicdrugs
Med chem lecture on Antihistaminicdrugs
 
Antihistamine
AntihistamineAntihistamine
Antihistamine
 
Autacoids - pharmacological actions and drugs related to them.
Autacoids - pharmacological actions and drugs related to them. Autacoids - pharmacological actions and drugs related to them.
Autacoids - pharmacological actions and drugs related to them.
 
Allergy and histamine
Allergy and histamineAllergy and histamine
Allergy and histamine
 
PHARMACOLOGY (HISTAMINE ITS ANTAGONISTS) pptx
PHARMACOLOGY (HISTAMINE  ITS ANTAGONISTS) pptxPHARMACOLOGY (HISTAMINE  ITS ANTAGONISTS) pptx
PHARMACOLOGY (HISTAMINE ITS ANTAGONISTS) pptx
 

Mais de Dr. Aseem Sharma (20)

Montelukast by aseem
Montelukast by aseemMontelukast by aseem
Montelukast by aseem
 
Blaschkoid dermatitis
Blaschkoid dermatitisBlaschkoid dermatitis
Blaschkoid dermatitis
 
Mrsa by aseem
Mrsa by aseemMrsa by aseem
Mrsa by aseem
 
Borrelia by aseem
Borrelia by aseemBorrelia by aseem
Borrelia by aseem
 
Targeted therapy psoriasis
Targeted therapy psoriasisTargeted therapy psoriasis
Targeted therapy psoriasis
 
Leprosy vaccines by aseem final
Leprosy vaccines by aseem finalLeprosy vaccines by aseem final
Leprosy vaccines by aseem final
 
Epidermal nevus
Epidermal nevusEpidermal nevus
Epidermal nevus
 
Leprous neuritis management by aseem
Leprous neuritis management by aseemLeprous neuritis management by aseem
Leprous neuritis management by aseem
 
Myiasis by aseem
Myiasis by aseemMyiasis by aseem
Myiasis by aseem
 
Lonafarnib by aseem
Lonafarnib by aseemLonafarnib by aseem
Lonafarnib by aseem
 
Acd by aseem
Acd by aseemAcd by aseem
Acd by aseem
 
Oral Sub Mucous Fibrosis by aseem
Oral Sub Mucous Fibrosis by aseemOral Sub Mucous Fibrosis by aseem
Oral Sub Mucous Fibrosis by aseem
 
Sjogren syndrome by aseem
Sjogren syndrome by aseemSjogren syndrome by aseem
Sjogren syndrome by aseem
 
Pellagra by aseem
Pellagra by aseemPellagra by aseem
Pellagra by aseem
 
Leprosy tests by aseem
Leprosy tests by aseemLeprosy tests by aseem
Leprosy tests by aseem
 
Wood's lamp by aseem
Wood's lamp by aseemWood's lamp by aseem
Wood's lamp by aseem
 
Scleroderma by aseem
Scleroderma by aseemScleroderma by aseem
Scleroderma by aseem
 
Phosphodiesterase-Inhibitors by Aseem
Phosphodiesterase-Inhibitors by AseemPhosphodiesterase-Inhibitors by Aseem
Phosphodiesterase-Inhibitors by Aseem
 
Erythema multiforme by aseem
Erythema multiforme by aseemErythema multiforme by aseem
Erythema multiforme by aseem
 
Demodex by aseem
Demodex by aseemDemodex by aseem
Demodex by aseem
 

Último

Ernakulam Call Girls 👙 6297143586 👙 Genuine WhatsApp Number for Real Meet
Ernakulam Call Girls 👙 6297143586 👙 Genuine WhatsApp Number for Real MeetErnakulam Call Girls 👙 6297143586 👙 Genuine WhatsApp Number for Real Meet
Ernakulam Call Girls 👙 6297143586 👙 Genuine WhatsApp Number for Real MeetCall Girls Chandigarh
 
Enjoyment ★ 8854095900 Indian Call Girls In Dehradun 🍆🍌 By Dehradun Call Girl ★
Enjoyment ★ 8854095900 Indian Call Girls In Dehradun 🍆🍌 By Dehradun Call Girl ★Enjoyment ★ 8854095900 Indian Call Girls In Dehradun 🍆🍌 By Dehradun Call Girl ★
Enjoyment ★ 8854095900 Indian Call Girls In Dehradun 🍆🍌 By Dehradun Call Girl ★indiancallgirl4rent
 
Tirupati Call Girls 👙 6297143586 👙 Genuine WhatsApp Number for Real Meet
Tirupati Call Girls 👙 6297143586 👙 Genuine WhatsApp Number for Real MeetTirupati Call Girls 👙 6297143586 👙 Genuine WhatsApp Number for Real Meet
Tirupati Call Girls 👙 6297143586 👙 Genuine WhatsApp Number for Real MeetCall Girls Service
 
Jaipur Call Girls 9257276172 Call Girl in Jaipur Rajasthan
Jaipur Call Girls 9257276172 Call Girl in Jaipur RajasthanJaipur Call Girls 9257276172 Call Girl in Jaipur Rajasthan
Jaipur Call Girls 9257276172 Call Girl in Jaipur Rajasthanindiancallgirl4rent
 
Call Girls Service In Goa 💋 9316020077💋 Goa Call Girls By Russian Call Girl...
Call Girls Service In Goa  💋 9316020077💋 Goa Call Girls  By Russian Call Girl...Call Girls Service In Goa  💋 9316020077💋 Goa Call Girls  By Russian Call Girl...
Call Girls Service In Goa 💋 9316020077💋 Goa Call Girls By Russian Call Girl...russian goa call girl and escorts service
 
❤️Call girls in Jalandhar ☎️9876848877☎️ Call Girl service in Jalandhar☎️ Jal...
❤️Call girls in Jalandhar ☎️9876848877☎️ Call Girl service in Jalandhar☎️ Jal...❤️Call girls in Jalandhar ☎️9876848877☎️ Call Girl service in Jalandhar☎️ Jal...
❤️Call girls in Jalandhar ☎️9876848877☎️ Call Girl service in Jalandhar☎️ Jal...chandigarhentertainm
 
Muzaffarpur Call Girls 👙 6297143586 👙 Genuine WhatsApp Number for Real Meet
Muzaffarpur Call Girls 👙 6297143586 👙 Genuine WhatsApp Number for Real MeetMuzaffarpur Call Girls 👙 6297143586 👙 Genuine WhatsApp Number for Real Meet
Muzaffarpur Call Girls 👙 6297143586 👙 Genuine WhatsApp Number for Real MeetCall Girls Service
 
Call Girls Patiala Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Patiala Just Call 9907093804 Top Class Call Girl Service AvailableCall Girls Patiala Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Patiala Just Call 9907093804 Top Class Call Girl Service AvailableDipal Arora
 
(Sonam Bajaj) Call Girl in Jaipur- 09257276172 Escorts Service 50% Off with C...
(Sonam Bajaj) Call Girl in Jaipur- 09257276172 Escorts Service 50% Off with C...(Sonam Bajaj) Call Girl in Jaipur- 09257276172 Escorts Service 50% Off with C...
(Sonam Bajaj) Call Girl in Jaipur- 09257276172 Escorts Service 50% Off with C...indiancallgirl4rent
 
Call Girl Amritsar ❤️♀️@ 8725944379 Amritsar Call Girls Near Me ❤️♀️@ Sexy Ca...
Call Girl Amritsar ❤️♀️@ 8725944379 Amritsar Call Girls Near Me ❤️♀️@ Sexy Ca...Call Girl Amritsar ❤️♀️@ 8725944379 Amritsar Call Girls Near Me ❤️♀️@ Sexy Ca...
Call Girl Amritsar ❤️♀️@ 8725944379 Amritsar Call Girls Near Me ❤️♀️@ Sexy Ca...Sheetaleventcompany
 
Hubli Call Girls 👙 6297143586 👙 Genuine WhatsApp Number for Real Meet
Hubli Call Girls 👙 6297143586 👙 Genuine WhatsApp Number for Real MeetHubli Call Girls 👙 6297143586 👙 Genuine WhatsApp Number for Real Meet
Hubli Call Girls 👙 6297143586 👙 Genuine WhatsApp Number for Real MeetCall Girls Service
 
VIP Call Girls Noida Sia 9711199171 High Class Call Girl Near Me
VIP Call Girls Noida Sia 9711199171 High Class Call Girl Near MeVIP Call Girls Noida Sia 9711199171 High Class Call Girl Near Me
VIP Call Girls Noida Sia 9711199171 High Class Call Girl Near Memriyagarg453
 
Chandigarh Escorts, 😋9988299661 😋50% off at Escort Service in Chandigarh
Chandigarh Escorts, 😋9988299661 😋50% off at Escort Service in ChandigarhChandigarh Escorts, 😋9988299661 😋50% off at Escort Service in Chandigarh
Chandigarh Escorts, 😋9988299661 😋50% off at Escort Service in ChandigarhSheetaleventcompany
 
Call Girls Service Faridabad 📲 9999965857 ヅ10k NiGhT Call Girls In Faridabad
Call Girls Service Faridabad 📲 9999965857 ヅ10k NiGhT Call Girls In FaridabadCall Girls Service Faridabad 📲 9999965857 ヅ10k NiGhT Call Girls In Faridabad
Call Girls Service Faridabad 📲 9999965857 ヅ10k NiGhT Call Girls In Faridabadgragmanisha42
 
VIP Call Girl Sector 32 Noida Just Book Me 9711199171
VIP Call Girl Sector 32 Noida Just Book Me 9711199171VIP Call Girl Sector 32 Noida Just Book Me 9711199171
VIP Call Girl Sector 32 Noida Just Book Me 9711199171Call Girls Service Gurgaon
 
Krishnagiri call girls Tamil aunty 7877702510
Krishnagiri call girls Tamil aunty 7877702510Krishnagiri call girls Tamil aunty 7877702510
Krishnagiri call girls Tamil aunty 7877702510Vipesco
 
Call Girl Raipur 📲 9999965857 whatsapp live cam sex service available
Call Girl Raipur 📲 9999965857 whatsapp live cam sex service availableCall Girl Raipur 📲 9999965857 whatsapp live cam sex service available
Call Girl Raipur 📲 9999965857 whatsapp live cam sex service availablegragmanisha42
 
(Deeksha) 💓 9920725232 💓High Profile Call Girls Navi Mumbai You Can Get The S...
(Deeksha) 💓 9920725232 💓High Profile Call Girls Navi Mumbai You Can Get The S...(Deeksha) 💓 9920725232 💓High Profile Call Girls Navi Mumbai You Can Get The S...
(Deeksha) 💓 9920725232 💓High Profile Call Girls Navi Mumbai You Can Get The S...Ahmedabad Call Girls
 
❤️♀️@ Jaipur Call Girls ❤️♀️@ Jaispreet Call Girl Services in Jaipur QRYPCF ...
❤️♀️@ Jaipur Call Girls ❤️♀️@ Jaispreet Call Girl Services in Jaipur QRYPCF  ...❤️♀️@ Jaipur Call Girls ❤️♀️@ Jaispreet Call Girl Services in Jaipur QRYPCF  ...
❤️♀️@ Jaipur Call Girls ❤️♀️@ Jaispreet Call Girl Services in Jaipur QRYPCF ...Gfnyt.com
 
Call Girl Gorakhpur * 8250192130 Service starts from just ₹9999 ✅
Call Girl Gorakhpur * 8250192130 Service starts from just ₹9999 ✅Call Girl Gorakhpur * 8250192130 Service starts from just ₹9999 ✅
Call Girl Gorakhpur * 8250192130 Service starts from just ₹9999 ✅gragmanisha42
 

Último (20)

Ernakulam Call Girls 👙 6297143586 👙 Genuine WhatsApp Number for Real Meet
Ernakulam Call Girls 👙 6297143586 👙 Genuine WhatsApp Number for Real MeetErnakulam Call Girls 👙 6297143586 👙 Genuine WhatsApp Number for Real Meet
Ernakulam Call Girls 👙 6297143586 👙 Genuine WhatsApp Number for Real Meet
 
Enjoyment ★ 8854095900 Indian Call Girls In Dehradun 🍆🍌 By Dehradun Call Girl ★
Enjoyment ★ 8854095900 Indian Call Girls In Dehradun 🍆🍌 By Dehradun Call Girl ★Enjoyment ★ 8854095900 Indian Call Girls In Dehradun 🍆🍌 By Dehradun Call Girl ★
Enjoyment ★ 8854095900 Indian Call Girls In Dehradun 🍆🍌 By Dehradun Call Girl ★
 
Tirupati Call Girls 👙 6297143586 👙 Genuine WhatsApp Number for Real Meet
Tirupati Call Girls 👙 6297143586 👙 Genuine WhatsApp Number for Real MeetTirupati Call Girls 👙 6297143586 👙 Genuine WhatsApp Number for Real Meet
Tirupati Call Girls 👙 6297143586 👙 Genuine WhatsApp Number for Real Meet
 
Jaipur Call Girls 9257276172 Call Girl in Jaipur Rajasthan
Jaipur Call Girls 9257276172 Call Girl in Jaipur RajasthanJaipur Call Girls 9257276172 Call Girl in Jaipur Rajasthan
Jaipur Call Girls 9257276172 Call Girl in Jaipur Rajasthan
 
Call Girls Service In Goa 💋 9316020077💋 Goa Call Girls By Russian Call Girl...
Call Girls Service In Goa  💋 9316020077💋 Goa Call Girls  By Russian Call Girl...Call Girls Service In Goa  💋 9316020077💋 Goa Call Girls  By Russian Call Girl...
Call Girls Service In Goa 💋 9316020077💋 Goa Call Girls By Russian Call Girl...
 
❤️Call girls in Jalandhar ☎️9876848877☎️ Call Girl service in Jalandhar☎️ Jal...
❤️Call girls in Jalandhar ☎️9876848877☎️ Call Girl service in Jalandhar☎️ Jal...❤️Call girls in Jalandhar ☎️9876848877☎️ Call Girl service in Jalandhar☎️ Jal...
❤️Call girls in Jalandhar ☎️9876848877☎️ Call Girl service in Jalandhar☎️ Jal...
 
Muzaffarpur Call Girls 👙 6297143586 👙 Genuine WhatsApp Number for Real Meet
Muzaffarpur Call Girls 👙 6297143586 👙 Genuine WhatsApp Number for Real MeetMuzaffarpur Call Girls 👙 6297143586 👙 Genuine WhatsApp Number for Real Meet
Muzaffarpur Call Girls 👙 6297143586 👙 Genuine WhatsApp Number for Real Meet
 
Call Girls Patiala Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Patiala Just Call 9907093804 Top Class Call Girl Service AvailableCall Girls Patiala Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Patiala Just Call 9907093804 Top Class Call Girl Service Available
 
(Sonam Bajaj) Call Girl in Jaipur- 09257276172 Escorts Service 50% Off with C...
(Sonam Bajaj) Call Girl in Jaipur- 09257276172 Escorts Service 50% Off with C...(Sonam Bajaj) Call Girl in Jaipur- 09257276172 Escorts Service 50% Off with C...
(Sonam Bajaj) Call Girl in Jaipur- 09257276172 Escorts Service 50% Off with C...
 
Call Girl Amritsar ❤️♀️@ 8725944379 Amritsar Call Girls Near Me ❤️♀️@ Sexy Ca...
Call Girl Amritsar ❤️♀️@ 8725944379 Amritsar Call Girls Near Me ❤️♀️@ Sexy Ca...Call Girl Amritsar ❤️♀️@ 8725944379 Amritsar Call Girls Near Me ❤️♀️@ Sexy Ca...
Call Girl Amritsar ❤️♀️@ 8725944379 Amritsar Call Girls Near Me ❤️♀️@ Sexy Ca...
 
Hubli Call Girls 👙 6297143586 👙 Genuine WhatsApp Number for Real Meet
Hubli Call Girls 👙 6297143586 👙 Genuine WhatsApp Number for Real MeetHubli Call Girls 👙 6297143586 👙 Genuine WhatsApp Number for Real Meet
Hubli Call Girls 👙 6297143586 👙 Genuine WhatsApp Number for Real Meet
 
VIP Call Girls Noida Sia 9711199171 High Class Call Girl Near Me
VIP Call Girls Noida Sia 9711199171 High Class Call Girl Near MeVIP Call Girls Noida Sia 9711199171 High Class Call Girl Near Me
VIP Call Girls Noida Sia 9711199171 High Class Call Girl Near Me
 
Chandigarh Escorts, 😋9988299661 😋50% off at Escort Service in Chandigarh
Chandigarh Escorts, 😋9988299661 😋50% off at Escort Service in ChandigarhChandigarh Escorts, 😋9988299661 😋50% off at Escort Service in Chandigarh
Chandigarh Escorts, 😋9988299661 😋50% off at Escort Service in Chandigarh
 
Call Girls Service Faridabad 📲 9999965857 ヅ10k NiGhT Call Girls In Faridabad
Call Girls Service Faridabad 📲 9999965857 ヅ10k NiGhT Call Girls In FaridabadCall Girls Service Faridabad 📲 9999965857 ヅ10k NiGhT Call Girls In Faridabad
Call Girls Service Faridabad 📲 9999965857 ヅ10k NiGhT Call Girls In Faridabad
 
VIP Call Girl Sector 32 Noida Just Book Me 9711199171
VIP Call Girl Sector 32 Noida Just Book Me 9711199171VIP Call Girl Sector 32 Noida Just Book Me 9711199171
VIP Call Girl Sector 32 Noida Just Book Me 9711199171
 
Krishnagiri call girls Tamil aunty 7877702510
Krishnagiri call girls Tamil aunty 7877702510Krishnagiri call girls Tamil aunty 7877702510
Krishnagiri call girls Tamil aunty 7877702510
 
Call Girl Raipur 📲 9999965857 whatsapp live cam sex service available
Call Girl Raipur 📲 9999965857 whatsapp live cam sex service availableCall Girl Raipur 📲 9999965857 whatsapp live cam sex service available
Call Girl Raipur 📲 9999965857 whatsapp live cam sex service available
 
(Deeksha) 💓 9920725232 💓High Profile Call Girls Navi Mumbai You Can Get The S...
(Deeksha) 💓 9920725232 💓High Profile Call Girls Navi Mumbai You Can Get The S...(Deeksha) 💓 9920725232 💓High Profile Call Girls Navi Mumbai You Can Get The S...
(Deeksha) 💓 9920725232 💓High Profile Call Girls Navi Mumbai You Can Get The S...
 
❤️♀️@ Jaipur Call Girls ❤️♀️@ Jaispreet Call Girl Services in Jaipur QRYPCF ...
❤️♀️@ Jaipur Call Girls ❤️♀️@ Jaispreet Call Girl Services in Jaipur QRYPCF  ...❤️♀️@ Jaipur Call Girls ❤️♀️@ Jaispreet Call Girl Services in Jaipur QRYPCF  ...
❤️♀️@ Jaipur Call Girls ❤️♀️@ Jaispreet Call Girl Services in Jaipur QRYPCF ...
 
Call Girl Gorakhpur * 8250192130 Service starts from just ₹9999 ✅
Call Girl Gorakhpur * 8250192130 Service starts from just ₹9999 ✅Call Girl Gorakhpur * 8250192130 Service starts from just ₹9999 ✅
Call Girl Gorakhpur * 8250192130 Service starts from just ₹9999 ✅
 

Antihistaminics

  • 2. Histamine • physiologically active amine C5H9N3 • plant and animal tissue • Released from mast cells as part of an allergic reaction (IgE / PG / LT / TNF-A / SP/ NKA Complement-mediated) -Gastric Secretion -Capillary Dilatation -Bronchoconstriction -Hypotension Imidazoline ring and amine gp
  • 3. Synthesis • Decarboxylation of AA Histidine by Histidine decarboxylase • Mast cells and basophils
  • 4. Mechanism of Action • Combining with specific cellular receptors on cells viz H1-H4 ; Leucocyte diapedesis  Neutrophil Chemotaxis  Mast Cell Degranulation • Primarily H1-mediated in Lewis’ Triple Response / UV • H2-H4 blockers / Atypical Antihistaminics found largely ineffective
  • 5. Type Location Function H1 Found on smooth muscles, endothelium, and central nervous system tissue Causes vasodilation, bronchoconstriction bronchial smooth muscle contraction, separation of endothelial cells (responsible for hives), and pain and itching due to insect stings; the primary receptors involved in allergic rhinitis symptoms and motion sickness; sleep regulation. H2 Located on parietal cells Primarily stimulate gastric acid secretion And we use antiacidic drugs for this receptor H3 Found on central nervous system and to a lesser extent peripheral nervous system tissue Decreased neurotransmitter release: histamine, acetylcholine, norepinephrine, serotonin H4 Found primarily in the basophils and in the bone marrow. It is also found onthymus, small intestine, spleen, andcolon. Plays a role in chemotaxis.
  • 6. 1st Antihistaminic • Piperoxan • Discovered in 1933 by Jeff Forneau and Daniel Bovent while developing a guinea pig animal model of anaphylaxis • They received the Nobel Prize in 1957
  • 7. Antihistaminics • Pharmaceutical agents that inhibit the action of histamine • blocking its attachment to histamine receptors (Classic Antihistaminics) • inhibiting the enzymatic activity of histidine decarboxylase (atypical antihistaminics) • The term antihistamine only refers to H1 receptor antagonists
  • 8. Classification H1 Blockers Traditional Sedatives (esrt 1st Gen <1981) Low-Sedation agents (erst 2nd Gen) H2 / H3 / H4-receptor Antagonists Tricyclic Antihistaminics Histidine Decarboxylase Enzyme-Inhibitors Mast Cell Degranulation Inhibitors
  • 10. Traditional Sedative H1 blockers • a
  • 12. H2 Receptor Antagonists • Parietal Cells – Inhibit Gastric Secretion • Cimetidine • Ranitidine • Nizatidine • Roxatidine • Famotidine • Lafutidine
  • 13. H3 Receptor Antagonists • Nootropics / Neuromodulators • Ciproxifan • Clobenpropit • Conessine
  • 14. H4 Receptor Antagonists • Immunomodulators • Thioperamide • VUF-6002 • JNJ 7777120
  • 15. Histidine Decarboxylase Inhibitors • Tritoqualine • Catechin
  • 16. Mast Cell Degranulation Inhibitors • Sodium Cromogylcate • Nedocromil • Inhalational Agents ; Ineffective in Cutaneous Dermatoses