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Liver: An Enigma By Dr. S K Mathur MS, FACS Sr. Consultant GI Surgeon HPB Surgery & Liver Transplantation,  Wockhardt hospitals, Mumbai Past President   :  Indian Chapter of International HPB Association Indian Association
Liver ,[object Object],[object Object],[object Object],[object Object],[object Object]
Liver: An Enigma ,[object Object],[object Object],[object Object],[object Object]
Liver: a Unique organ ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Prediction of Hepatic Insufficiency Hepatic Volumetry Normal Liver : Segments  Volume 5 + 8  30 % 6 + 7  35 % 1 + 4  20 % 2 + 3  15 % 65 % of Right Liver 35 % of Left Liver (Stone et al Am J Surg 1969)
Liver : Uniqueness It has large functional reserve ,[object Object]
Liver : Uniqueness Capacity for Regeneration In 6 weeks liver regenerates to 90% of its original volume
In Greek mythology, Prometheus (Ancient Greek:"forethought")[1] is a Titan known for his wily intelligence, who stole fire from Zeus and gave it to mortals for their use.[2] Zeus then punished him for his crime by having him bound to a rock while an eagle ate his liver every day only to have it grow back to be eaten again the next day.
Liver:  an enigma to Clinicians ,[object Object],[object Object],[object Object],[object Object]
Liver Tumors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Liver Cancer  (Hepatocellular  Carcinoma)
Hepatocellular Carcinoma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hepatocellular Carcinoma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hepatocellular Carcinoma ,[object Object],[object Object]
Digestive cancers at TMH 1994-95 Site  1994 1995 All GI 2277 2347 Esophagus 902  921 Large bowel 617  666 Stomach 359  341 Gall bladder 161 167 Pancreas   1 12 134 Liver 88 88 Others 28 30
Hepatocellular Carcinoma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Etiology :
Hepatocellular Carcinoma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Etiology :
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Hepatocellular Carcinoma Etiology :
Hepatocellular Carcinoma Clinical Presentations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hepatocellular Carcinoma Diagnosis : Tumour Markers: - - AFP > 400 ng/ml - DCP (des - y - carboxy prothrombin)  - CEA
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],For small HCC (3mm) Imaging Modalities:
Hepatocellular Carcinoma ,[object Object],[object Object],[object Object]
Hepatocellular Carcinoma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],Non surgical therapies
[object Object],[object Object],[object Object]
SURGERY- ANTERIOR TRANSHEPATIC RESECTION Weight 2 .5Kg
Management of HCC ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Management of HCC ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Story of a patient with recurrent liver cancer Agony to Smile
HISTORY ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Story of a patient with recurrent liver cancer ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
IVC Tumors Tumor Liver
Advised Palliative Treatment: Underwent two cycles of TACE in April and June 2009 One tumor nodule which was flush with the IVC could not be embolised
Management of HCC ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Selection Criteria for Repeat Hepatectomy in Patients With Recurrent Hepatocellular Carcinoma Masami Minagawa, MD,* Masatoshi Makuuchi, MD,* Tadatoshi Takayama, MD,† and Norihiro Kokudo, MD*  Ann Surg.  2003 ,[object Object],[object Object],[object Object]
Selection Criteria for Repeat Hepatectomy in Patients With Recurrent Hepatocellular  Carcinoma  Masami Minagawa,   MD,*   Masatoshi Makuuchi, MD,* Tadatoshi Takayama, MD,† and Norihiro Kokudo, MD*   Ann Surg.  2003 ,[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
Story of a patient with recurrent liver cancer ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
CT Scan
Sectorectomy
Right hepatectomy
Story of a patient with recurrent liver cancer Video
[object Object],[object Object],[object Object],[object Object],[object Object]
Dealing with Cancer and Terrorism ,[object Object],[object Object],[object Object]
Hepatocellular Carcinoma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Conclusions
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Early Detection Screening or Survilliance
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Appropriate Management
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Appropriate Management
THANK YOU

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Kinds of Liver Cancers diagnosis and Treatements

  • 1. Liver: An Enigma By Dr. S K Mathur MS, FACS Sr. Consultant GI Surgeon HPB Surgery & Liver Transplantation, Wockhardt hospitals, Mumbai Past President : Indian Chapter of International HPB Association Indian Association
  • 2.
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  • 5. Prediction of Hepatic Insufficiency Hepatic Volumetry Normal Liver : Segments Volume 5 + 8 30 % 6 + 7 35 % 1 + 4 20 % 2 + 3 15 % 65 % of Right Liver 35 % of Left Liver (Stone et al Am J Surg 1969)
  • 6.
  • 7. Liver : Uniqueness Capacity for Regeneration In 6 weeks liver regenerates to 90% of its original volume
  • 8. In Greek mythology, Prometheus (Ancient Greek:"forethought")[1] is a Titan known for his wily intelligence, who stole fire from Zeus and gave it to mortals for their use.[2] Zeus then punished him for his crime by having him bound to a rock while an eagle ate his liver every day only to have it grow back to be eaten again the next day.
  • 9.
  • 10.
  • 11. Liver Cancer (Hepatocellular Carcinoma)
  • 12.
  • 13.
  • 14.
  • 15. Digestive cancers at TMH 1994-95 Site 1994 1995 All GI 2277 2347 Esophagus 902 921 Large bowel 617 666 Stomach 359 341 Gall bladder 161 167 Pancreas 1 12 134 Liver 88 88 Others 28 30
  • 16.
  • 17.
  • 18.
  • 19.
  • 20. Hepatocellular Carcinoma Diagnosis : Tumour Markers: - - AFP > 400 ng/ml - DCP (des - y - carboxy prothrombin) - CEA
  • 21.
  • 22.
  • 23.
  • 24.
  • 25.
  • 26. SURGERY- ANTERIOR TRANSHEPATIC RESECTION Weight 2 .5Kg
  • 27.
  • 28.
  • 29. Story of a patient with recurrent liver cancer Agony to Smile
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  • 31.
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  • 33.
  • 35. Advised Palliative Treatment: Underwent two cycles of TACE in April and June 2009 One tumor nodule which was flush with the IVC could not be embolised
  • 36.
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  • 39.
  • 40.
  • 44. Story of a patient with recurrent liver cancer Video
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  • 50.