My thesis of B.PHARM... Thanks to batchmates....

1. 5

2. 4

3. 3

4. 2

5. 1

6. PROJECT START

7. DEVELOPMENT AND EVALUATION OF XYLOGLUCAN MATRIX RELEASE TABLETS CONTAINING GLIPIZIDE Project submitted to Acharya Nagarjuna University, Guntur . DEPARTMENT OF PHARMACEUTICS VICTORIA COLLEGE OF PHARMACY Under the guidance of Mr. P. Arun Kumar , M.Pharm.,

13. Extraction of Xyloglucan 20 gm of tamarind kernel powder Added to 200ml of cold distilled water to prepare a slurry Slurry poured into 800 ml of boiled distilled water Solution was boiled for 20 mins in stirred condition Thin clear solution kept over night Centrifuged at 5000 rpm for 20 mins Supernatant liquid was separat ed Poured into excess absolute alcohol and stirred . Precipitate was formed Washed with 200 ml absolute ethanol Dried @ 50 o C

14. Preparation of matrix tabs FORMULA : XGL 1 XGL2 XGL3 XGL4 XGL5 Glipizide 100 100 100 100 100 Xyloglucan 100 150 150 150 150 Hydroxyl propyl methyl cellulose - - 100 - - Cellulose acetate phthalate - - - 100 - Ethyl cellulose - - - - 100 Lactose 180 130 30 30 30 Magnesium sterate 8 8 8 8 8 Talc 12 12 12 12 12

16. Preformulation studies FTIR OF GLIPIZIDE

17. FTIR OF GLIPIZIDE + XYLOGLUCAN

19. Dissolution Studies TIME (In Hours) %Drug release F1 fomulation exhibits 99 % drug release for prolonged duration .

20. COMPARISON OF DISSOLUTION RATES TIME (hr) F1 F2 F3 F4 F5 0 0 0 0 0 0 1 9.321 6.561 9.614 6.514 8.246 2 19.563 13.428 17.328 15.321 15.251 3 30.686 23.324 26.412 23.416 25.143 4 42.414 31.656 34.565 32.162 33.359 5 58.512 39.552 40.591 44.814 41.187 6 73.855 46.124 49.56 52.916 49.237 7 84.661 63.768 55.128 61.123 57.591 8 95.622 79.812 64.325 74.752 66.186

21. Physical parameters DEPARTMENT OF PHARMACEUTICS VICTORIA COLLEGE OF PHARMACY

26. THANK YOU !! PROJECT SUBMITTED BY: G. Shanthi Priyanka G. Rajesh J. Vijaya Bhaskar V. Manohar K. Sowjanya P. Sukesh L. V. Kishore U.V. Sudheer GUIDED BY: Mr. P. Arun Kumar, M.Pharm. , Victoria college of pharmacy Nallapadu Guntur