The document discusses clinical practice guidelines for treating panic disorder and agoraphobia. It provides information on evaluating guidelines using levels of evidence and the Appraisal of Guidelines Research & Evaluation (AGREE) method. It also summarizes the Australian and New Zealand clinical practice guidelines for treating panic disorder and agoraphobia published in 2003.

1. Evaluating a Guideline Treatment of panic disorder and Agoraphobia: clinical practice guideline (CPG)

2. What is EBM? Best Research Evidence Patient Values Clinical Expertise

3. Levels of evidence

4. National Health and Medical Research Council (NHMRC) levels of evidence I Evidence obtained from a systematic review of all relevant randomised controlled trials II Evidence obtained from at least one properly designed randomised controlled trial III - 1 Evidence obtained from well-designed pseudorandomised controlled trials (alternate allocation or some other method) III - 2 Evidence obtained from comparative studies (including systematic reviews of such studies) with concurrent controls and allocation not randomised, cohort studies, case-control studies, or interrupted time series with a control group III - 3 Evidence obtained from comparative studies with historical control, two or more single arm studies, or interrupted time series without a parallel group IV Evidence obtained from case series, either post-test or pretest/ post-test

5. Evidence Pyramid

6. Evidence Pyramid

7. Appraisal of Guidelines Research & Evaluation ( AGREE )

13. Clinical Practice Guidelines Depression Schizophrenia Bipolar Disorder Deliberate Self Harm Anorexia Nervosa Panic Disorder & Agoraphobia Clinician Consumer

14. System Application of nationally developed CPGs Systematic Review (Multi Disciplinary Panel) Draft CPG National Endorsement (AUS/ NZ) Decision to Diffuse, disseminate & develop implementation programs Local Adaptation Decision Support System CPD Community/ Media/ Consumer

15. Applying Guideline in Clinical Practice CPG to assess Current practice Local Problem Solving Provide Guide to pts

17. Applying Guideline in Clinical Practice PLAN MONITOR REVIEW ACT

18. Panic disorder and agoraphobia