Immunopharmacology Overview

IMMUNOPHARMACOLOGY Ma. Janetth B. Serrano, M.D., DPBA

IMMUNOPHARMACOLOGY ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],IMMUNOPHARMACOLOGY

IMMUNOPHARMACOLOGY 0psonized bacteria Macrophage APC T lymphocyte IL-2 IL-2 IFN-  Activated Macrophage Activated NK cells Activated Cytotoxic T cell CELL-MEDIATED IMMUNITY B lymphocyte IL-4,IL-5 TH 1 TH 2 Memory B Cells ,[object Object],[object Object],[object Object],HUMORAL IMMUNITY IFN-  TNF-  IFN- 

[object Object],[object Object],[object Object],[object Object],[object Object],IMMUNOPHARMACOLOGY

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Immunosuppressants IMMUNOPHARMACOLOGY

Corticosteroids IMMUNOPHARMACOLOGY

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[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],IMMUNOPHARMACOLOGY

Cyclosporin IMMUNOPHARMACOLOGY

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Sirolimus (rapamycin) IMMUNOPHARMACOLOGY

Interferons IMMUNOPHARMACOLOGY

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],IMMUNOPHARMACOLOGY

TNF- α binding drugs IMMUNOPHARMACOLOGY

Mycophenolate Mofetil IMMUNOPHARMACOLOGY

15-Deoxyspergualin IMMUNOPHARMACOLOGY

[object Object],[object Object],[object Object],IMMUNOPHARMACOLOGY

Thalidomide IMMUNOPHARMACOLOGY

[object Object],[object Object],[object Object],IMMUNOPHARMACOLOGY CYTOTOXIC Agents:

Azathioprine IMMUNOPHARMACOLOGY

Leflunomide IMMUNOPHARMACOLOGY

Cyclophosphamide IMMUNOPHARMACOLOGY

Antibodies as Immunosuppressive Agents ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],IMMUNOPHARMACOLOGY

[object Object],[object Object],[object Object],[object Object],IMMUNOPHARMACOLOGY MONOCLONAL ANTIBODIES :

Muromonab-CD3 IMMUNOPHARMACOLOGY

[object Object],[object Object],IMMUNOPHARMACOLOGY Muromonab-CD3

[object Object],[object Object],[object Object],IMMUNOPHARMACOLOGY MONOCLONAL ANTIBODIES :

IMMUNOMODULATORS ,[object Object],- hairy cell leukemia - chronic myelogenous leukemia - malignant melanoma - Kaposi’s sarcoma - anticancer  renal cell CA, carcinoid syndrome, T cell leukemia

IMMUNOMODULATORS ,[object Object],GM-CSF Interferons & IL-2 TNF-alpha Interleukin-2 Interferon-gamma Interferon-beta

IMMUNOMODULATORS ,[object Object],Melanoma and Prostate cancer (+) effects in response to Hep B vaccine Malignant melanoma Soft tissue sarcoma of extremities Metastatic renal cell CA Malignant melanoma Chronic granulomatous disease Relapsing type multiple sclerosis

LEVAMISOLE IMMUNOPHARMACOLOGY IMMUNOMODULATORS IMMUNOPHARMACOLOGY

IMMUNOPHARMACOLOGY IMMUNOMODULATORS IMMUNOPHARMACOLOGY - antiparasitic agent - potentiate action of fluorouracil in adjuvant therapy of Dukes class C colorectal CA - other uses: > hodgkin’s lymphoma > RA

BCG (Bacille-Camille-Guarin) IMMUNOPHARMACOLOGY IMMUNOMODULATORS IMMUNOPHARMACOLOGY

IMMUNOPHARMACOLOGY IMMUNOMODULATORS IMMUNOPHARMACOLOGY - immunization against tuberculosis - Adjuvant in intravesical therapy for SF bladder CA

IMMUNOPHARMACOLOGY IMMUNOMODULATORS IMMUNOPHARMACOLOGY ,[object Object],[object Object],[object Object],[object Object],[object Object]

Immunopharmacology Overview

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Immunopharmacology Overview