Organophosphate Poisoning Case Study: Intermediate Syndrome and Delayed Neuropathy

DR. PRIYA KUBENDIRAN PROF. DR. MAGESH KUMAR M 1 UNIT

The Case… ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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FINAL DIAGNOSIS ,[object Object],[object Object],[object Object]

OPC POISONING ,[object Object],[object Object],[object Object],[object Object]

ANS Preganglionic Parasympathetic Sympathetic Somatic Nerves Ach Ach Ach Ach Ach Ganglion Epi Skeletal Muscle Ach Ach Norepi Via Bld Effector Organs + Pupil -Heartrate +Exocrine Glands +GIT Smooth Muscle +Lung Smooth Muscle +Sweatgld -Bloodvessel [Some ] - Pupil +Heart Rate -Gastrointestinal SM -Lung SM +Blood Vessels [Most] Often The Parasympathetic Features Predominates Post Ganglionic

Clinical Syndrome ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],+ Death Respiratory failure }

Muscarinic Effects (Wadia Type 1 syndrome ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

NICOTINIC FEATURES: CENTRAL : LESS WITH CARBAMATES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

DELAYED COMPLICATIONS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],INTERMEDIATE SYNDROME : [FIRST DESCRIBED IN 1987] [WADIA TY-II]

OPIDN ( Organophosphorus induced delayed neurotoxicity) ,[object Object],[object Object],[object Object],[object Object]

Pathogenesis ,[object Object],[object Object],[object Object]

Neurological dysfunction of OPIDN ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Factors involved in the Development of OPIDN ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Chlorpyrifos-induced delayed polyneuropathy ,[object Object],Eugenio Capodicasa et al, Archives of Toxicology Volume 65, Number 2 ,

CASE REPORT -Toxin induced neuropathy presenting as acute inflammatory demyelinating polyneuropathy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

CASE REPORT - Guillain-Barre Syndrome Due to Organophosphate Compound Poison ,[object Object],[object Object]

Methylprednisolone treatment of an organophosphorus-induced delayed neuropathy ,[object Object],Thomas Baker and Anna Stanec Toxicology and Applied Pharmacology Volume 79, Issue 2 , 30 June 1985,

Effects of Prednisolone and complex of vitamin B1,B2,B6 & B12 on organophosphorus compound induced delayed neurotoxicity Fengyuan Piao et al, J Occup Health 2004 ,[object Object]

Chronic organophosphate induced neuro psychiatric disorder (COPIND) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Organophosphate Poisoning Case Study: Intermediate Syndrome and Delayed Neuropathy

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Organophosphate Poisoning Case Study: Intermediate Syndrome and Delayed Neuropathy