A Case of Antiphospholipid Antibody Syndrome

Physician’s Meet March 17 2010 Dr Jishanth M Prof. Dr A Gowrishankar’s Unit, M4

An Interesting Hypercoagulable State

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

System Examination: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

PROVISIONAL DIAGNOSIS ,[object Object],[object Object],[object Object]

INVESTIGATIONS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Investigation contd… ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object]

CT ANGIOGRAM ,[object Object],[object Object],[object Object],[object Object]

Further investigations ,[object Object],[object Object],[object Object],[object Object],[object Object]

Interlobular septal thickening B/l cystic spaces with peribrochial fibrosis

FINAL DIAGNOSIS ,[object Object],[object Object],[object Object]

Antiphospholipid Syndrome ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Antiphospholipid Syndrome - Etiology ,[object Object],[object Object],[object Object],[object Object]

Drug Induced aPLs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Antiphospholipid antibodies ,[object Object],[object Object],[object Object],[object Object],[object Object]

Antiphospholipid Antibodies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Antiphospholipid Antibodies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Beta 2 Glycoprotein I ,[object Object],[object Object],[object Object],[object Object],[object Object]

Significance of aPLs ,[object Object],[object Object]

APS Pathophysiology ,[object Object],platelets Coagulation cascade Endothelial cells Activate platelet aggregation Inhibit Protein C, Protein S, thrombomodulin, antithrombin III fibrinolysis TF, adhesion molecules and proinflammatory cytokines Placental tissue Trophoblastic cell growth, apoptosis IL-3 Complement system

Pathogenesis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

REVISED SAPPORO CRITERIA, SYDNEY 2006 Clinical Criteria ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Laboratory criteria ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Clinical Manifestations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Catastrophic APS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Treatment-General ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Anticoagulation ,[object Object],[object Object],[object Object]

Treatment-Other ,[object Object],[object Object],[object Object]

Treatment of Catastrophic APS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Future directions of treatment of APS ,[object Object],[object Object],[object Object],[object Object],[object Object]

Summary ,[object Object],[object Object],[object Object],[object Object],[object Object]

Uniqueness of the case under discussion….

A Case of Antiphospholipid Antibody Syndrome

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A Case of Antiphospholipid Antibody Syndrome

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