4. HORMONES SECRETED FROM PARATHYROID
GLAND
Secreteparathyroid
hormone (PTH)
Humoral stimuli
Most important regulator
of Ca2+ homeostasis of
the blood
Hypercalcemic hormone
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5. HYPERPARATHYROIDISM
Etiology Pathogenesis
Overproduction of Bone Pain
the cells secreting Depression
PTH Frequent urination
Parathyroid
Kidney stones
develops a tumor
Nausea
Loss of appetite
Treatment
Remove the tumor
surgically
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6. HYPOPARATHYROIDISM
Etiology Pathogenesis
Family History Heavier periods in
Autoimmune Disorder females
Excessive radiation
Cataracts
treatment
Low levels of Mg in Tingling sensations
blood Muscles spasms
Treatment Dry hair and skin;
restore the Ca and brittle nails
mineral balance in Weakened tooth
the body enamel in kids
Take vitamins with
Calcium and 6
Vitamin D
7. OSTEOPOROSIS
Etiology
Loss of Calcium
Too much PTH
Pathogenesis
"Thin Bones"
Bones break and
fracture easier
Loss of energy
Feel old
Bones hurt
Treatment
Remove the bad 7
parathyroid gland
8. PARATHYROID CANCER
Etiology Pathogenesis
Out of control PTH
Weakness
production
Family history Lump in neck
Hyperparathyroidism Trouble swallowing
Loss of appetite
Unquenchable thirst
Treatment
Surgery
Radiation therapy
8
-located on the thyroid gland. -Most people have four pea-sized parathyroid glands ~relatively small gland compared to the other glands and organs around it.
-PTH is a hypercalcemic hormone because it acts to increase blood levels of Calcium-Decreasing blood Ca levels prompt the release of PTH, which causes blood Ca levels to rise, ending the stimulus for PTH release
-surgery can be done in 13 minutes or less
-Not enough Ca; too much Phosphorous-cataracts: cloudy lens-muscle spasms = tetany-Hypoparaythroidism can be acquired from accidental removal or damage to parathyroid gland during surgery (i.e. to remove throat cancer) (less common now)-usually a chronic disorder
-extremely rare with about one case in every 1,000 patients with parathyroid disease-symptoms are similar to those of hyperparathyroidism because both involve too much PTH-All patients with hyperparathyroidism have elevated parathyroid hormone in their blood, those with benign disease tend to have levels in the "hundreds" where as those with parathyroid cancer tend to have values in the "thousands." -The parathyroid gland and the half of the thyroid on the same side as the cancer is typically removed.