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MongoDB and academia Jan Aerts, PhD Wellcome Trust Sanger Institute Hinxton, UK [email_address] @jandot
Disclaimer 1
Disclaimer 2
Acknowledgments MongoDB community Caren Brockington 10gen
 
transcriptomics genomics proteomics *omics
transcriptomics genomics proteomics *omics instantiationomics metabolomics spliceomics interactomics metallomics lipidomics orfeomics phenomics histomics
Academia != industry
heterogeneous systems
transitory
little optimization
slow adoption of new technology (don't break anything that works)
data management = afterthought money
Who are the players?
[object Object],genome hackers (lone bioinformaticians) bench-based scientists Drawings by Morag Ann Lewis
[object Object],genome hackers (lone bioinformaticians) bench-based scientists heavy investment in infrastructure/pipelines data exchange => standards!
[object Object],genome hackers (lone bioinformaticians) bench-based scientists little investment in infrastructure little time/effort for optimization one-off getting it done creating legacy need IT support for heavier work often self-taught
[object Object],genome hackers (lone bioinformaticians) bench-based scientists use whatever everyone else is using "normalization?"
The data landscape
1. Flat text files ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
1. Flat text files ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
1. Flat text files ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
1. Flat text files ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
1. Flat text files ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
2. Binary compressed flat files ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
3. MySQL and Oracle Curated data Meta-data Raw data: BLOBs ,[object Object],[object Object],[object Object],[object Object],[object Object],Denormalized copy
4. AceDB -  A   C aenorhabditis  e legans  d ata b ase object-oriented Author "Patel B"  Full_name "Bala Patel"  Laboratory CB  Paper [cgc1011]  Paper [cgc533]  Mail "Laboratory of Molecular Biology"  Mail "Hills Road, Cambridge"  Fax "050 3456789"    Paper [cgc533]  Title "Yet more of those Genes"  Journal "Cell Reports"  Volume 3  Year 1993
 
Challenges in *omics - Where can MongoDB play a role?
explosion of data every  researcher must be able to handle data
low stepping stone for bench-based scientists big data
 
Takeoff within research community? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Thank you! Questions? [email_address] @jandot http://saaientist.blogspot.com

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Mongo db and_academia

Notas do Editor

  1. * not an expert. Further in the presentation I’ll explain why.
  2. * personal ideas/opinions; not Sanger
  3. My background
  4. there are hurdles for adoption in academia
  5. Why is there slow adoption?
  6. Why is there slow adoption?
  7. "need IT support for heavier work": set up MongoDB server => what if need sharded cluster? => investment from IT "creating legacy": if it's something that will be used after you're gone, you don't want to use a technology that is not supported or actively used within the organization
  8. Why is there slow adoption?
  9. Not really tab-delimited anymore because too structured Self-taught => simple scripting languages!
  10. Would benefit most. "bench-based scientists": are more and more learning perl and working with tab-delimited files to go to database: json looks more like how they think than having to cope with normalization steps in a relational database