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Ibogaine Therapy:
Forms and Dose Regimens


     Howard S. Lotsof, B.F.A., C.M.A.
                President
        Dora Weiner Foundation
           Staten Island, NY
       http://www.doraweiner.org
Forms in Current Use

• Botanical - root bark

• Total alkaloid extract


• purified ibogaine
Tabernanthe iboga shrub
Roots contain ibogaine
Total Alkaloid Extract




 Large piece 2cm x 2cm, approx 4 grams
        Estimate 15% ibogaine
             Courtesy Sara Glatt
Ibogaine HCl




   99.4% purity
All forms have
multiple treatment
applications
1. Chemical use disorders
2. Pain management
3. Psychotherapy
4. Initiatory sessions
Each form has

1. Different onset
2. Different duration of
   action
3. And significant diversity
   across the patient
   population
Onset of Effects (min)

160
140
120
100
                           Full Effect
 80
 60                        Onset
 40
 20
  0
       HCl   Extract
Period of visuaization (hours)

16
14
12                             Extended
10
                               Visualization
 8
 6                             Onset
 4
 2
 0
         HCl   Extract
Duration of Action (days)

10
 9
 8
 7                           Residual
 6
 5
 4                           Principal
 3
 2
 1
 0
       HCl   Extract
Effect on sleep (weeks)

10
 9
 8
 7                             Residual
 6
 5
 4                             Principal
 3
 2
 1
 0
      HCl
Dose and Dose Regimen

   1. Single dose
   2. Multiple
     1. Escalating
     2. Deescalating
     3. Linear
All doses are representative. Doses,
including single administration doses are
determined on a patient by patient basis.
The graphs of dose regimens and
information that follow should not be used
by persons without experience to self-
administer or administer to others any
dose of ibogaine or total alkaloid extract
of Tabernanthe iboga .
Single dose regimens usually fall between
10mg/kg and 22mg/kg depending on type
of therapy offered: opioid dependence,
stimulant dependence, psychospiritual,
etc. Most doses fall in the 15mg/kg -
20mg/kg dose range to reach full
therapeutic effects.
ibogaine HCl (mg/hour)
             20mg methadone
              total - 1000mg
400
350       350
300
250
200              175    175    175          HCl
150                                   125
100
 50
  0
      0         h1     h2     h3     h4
ibogaine HCl (mg/kg/hour)
             stimulant therapy
                courtesy Eric Taub



16
14
12
10                     10
                                          HCl
 8
 6
 4
         2.5                          3
 2
     0             h2                h3
ibogaine HCl (mg/kg/hour)
                 heroin therapy
                total 21.5mg.kg
                      courtesy Eric Taub



16
14              14
12
10
                                           HCl
 8
 6
                       5
 4
 2       2.5
     0         1h    h12
ibogaine HCl (mg/kg/hour)
                methadone therapy
                 total 36.5 mg/kg
                             courtesy Eric Taub



16
14
12                                 12
10
 8                                                                  HCl
 6
 4                                       3        3   3   3
     2.5   2.5   2.5   2.5   2.5
 2
     0
           13 23 30 34 36 59 68 77 89
                                                              100
extract (grams/hour)
                heroin therapy
                 total 7 grams
                  courtesy Sara Glatt



6
5
4
3       3    3                          Exract
2
1                    1

0
    0       12    36          48
extract (grams/hour/day)
                    methadone therapy
                       total 11 grams
                        courtesy Sara Glatt



6
5
4
3       3    3                                         Exract
2
1                  1    1      1       1       1

0
    0       12    36   d2   d4     d6         d8 d10
extract (grams/hour)
                        HCl (mg/hour)
                    methadone 300mg/day
                        total extract 9 grams
                          total HCl 400mg
                          courtesy Marc Emery



6   5.2
5                       3.8
4                                               Exract
3
2                                               HCl
1           0.1   0.1           0.1     0.1
0
    0
          h72 h96 h120h168h192
All doses and dose regimens
shown or discussed are
representative and are not
indicated to be provided to any
other patient or subject. All doses
and dose regimens are made on a
patient by patient basis upon
knowledge and prior art.

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Elephant Sunshine

  • 1. Ibogaine Therapy: Forms and Dose Regimens Howard S. Lotsof, B.F.A., C.M.A. President Dora Weiner Foundation Staten Island, NY http://www.doraweiner.org
  • 2. Forms in Current Use • Botanical - root bark • Total alkaloid extract • purified ibogaine
  • 5. Total Alkaloid Extract Large piece 2cm x 2cm, approx 4 grams Estimate 15% ibogaine Courtesy Sara Glatt
  • 6. Ibogaine HCl 99.4% purity
  • 7. All forms have multiple treatment applications 1. Chemical use disorders 2. Pain management 3. Psychotherapy 4. Initiatory sessions
  • 8. Each form has 1. Different onset 2. Different duration of action 3. And significant diversity across the patient population
  • 9. Onset of Effects (min) 160 140 120 100 Full Effect 80 60 Onset 40 20 0 HCl Extract
  • 10. Period of visuaization (hours) 16 14 12 Extended 10 Visualization 8 6 Onset 4 2 0 HCl Extract
  • 11. Duration of Action (days) 10 9 8 7 Residual 6 5 4 Principal 3 2 1 0 HCl Extract
  • 12. Effect on sleep (weeks) 10 9 8 7 Residual 6 5 4 Principal 3 2 1 0 HCl
  • 13. Dose and Dose Regimen 1. Single dose 2. Multiple 1. Escalating 2. Deescalating 3. Linear
  • 14. All doses are representative. Doses, including single administration doses are determined on a patient by patient basis. The graphs of dose regimens and information that follow should not be used by persons without experience to self- administer or administer to others any dose of ibogaine or total alkaloid extract of Tabernanthe iboga .
  • 15. Single dose regimens usually fall between 10mg/kg and 22mg/kg depending on type of therapy offered: opioid dependence, stimulant dependence, psychospiritual, etc. Most doses fall in the 15mg/kg - 20mg/kg dose range to reach full therapeutic effects.
  • 16. ibogaine HCl (mg/hour) 20mg methadone total - 1000mg 400 350 350 300 250 200 175 175 175 HCl 150 125 100 50 0 0 h1 h2 h3 h4
  • 17. ibogaine HCl (mg/kg/hour) stimulant therapy courtesy Eric Taub 16 14 12 10 10 HCl 8 6 4 2.5 3 2 0 h2 h3
  • 18. ibogaine HCl (mg/kg/hour) heroin therapy total 21.5mg.kg courtesy Eric Taub 16 14 14 12 10 HCl 8 6 5 4 2 2.5 0 1h h12
  • 19. ibogaine HCl (mg/kg/hour) methadone therapy total 36.5 mg/kg courtesy Eric Taub 16 14 12 12 10 8 HCl 6 4 3 3 3 3 2.5 2.5 2.5 2.5 2.5 2 0 13 23 30 34 36 59 68 77 89 100
  • 20. extract (grams/hour) heroin therapy total 7 grams courtesy Sara Glatt 6 5 4 3 3 3 Exract 2 1 1 0 0 12 36 48
  • 21. extract (grams/hour/day) methadone therapy total 11 grams courtesy Sara Glatt 6 5 4 3 3 3 Exract 2 1 1 1 1 1 1 0 0 12 36 d2 d4 d6 d8 d10
  • 22. extract (grams/hour) HCl (mg/hour) methadone 300mg/day total extract 9 grams total HCl 400mg courtesy Marc Emery 6 5.2 5 3.8 4 Exract 3 2 HCl 1 0.1 0.1 0.1 0.1 0 0 h72 h96 h120h168h192
  • 23. All doses and dose regimens shown or discussed are representative and are not indicated to be provided to any other patient or subject. All doses and dose regimens are made on a patient by patient basis upon knowledge and prior art.

Editor's Notes

  1. Workshop participants will be asked if they have a copy of the manual. If everyone has a copy, fine. If not, those who do not want the manual will be asked to give their copy to someone who wants a copy.