This is a short presentation that shows the working mechanism and the applications of the new ionization source, for mass spectrometry, named Surface Activated Chemical Ionization (SACI). More informations can be found at the URL: http://www.isbiotechnology.com

1. Surface Activated Chemical Ionization – applications to low molecular weight drugs analysis Simone Cristoni

2. Surface Activated Chemical Ionization

3. Surface Activated Chemical Ionization Controlled, low potential Metal surface

7. Analysis of addictive drugs Urine 2 ng/mL APCI SACI

8. Analysis of addictive drugs Saliva 10 ng/mL of 6-MAM 1 ng/mL of 6-MAM 4 Retention time (min)‏ 14 a) SACI‏ Signal intensity HCT 0 5.3E+5 12.40 LTQ 4 Retention time (min)‏ 14 a) SACI‏ Signal intensity HCT 0 4.1E+4 LTQ 4 0 Signal intensity 3.2E+2 Retention time (min)‏ 14 b) APCI HCT LTQ Signal intensity 0 1.89E+2 Retention time (min)‏ 14 c) ESI‏ 4 HCT LTQ 0 Signal intensity 5.6E+2 Retention time (min)‏ 14 b) APCI 4 HCT LTQ Signal intensity 4.2E+3 Retention time (min)‏ 14 c) ESI‏ 0 4 LTQ HCT 12.20 12.30

11. Analysis of pesticides water

12. Analysis of pesticides spinach

15. Analysis of pesticides spinach

16. Analysis of OTA Wine – 10 ng/mL

19. SACI demo site Web site: http://www.isbiotechnology.com

21. www.bdal.com