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Acute Renal Failure And Sepsis

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Acute Renal Failure and Sepsis Michael Fernando M.D. PGY-3 Cleveland Clinic July 18, 2007
Clinical Definition of Sepsis
RIFLE classification of Acute Renal Failure ,[object Object],[object Object],[object Object],[object Object],[object Object]
Occurrence of Acute Renal Failure in Sepsis
Objectives ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hemodynamics and Hormones ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pathophysiology
Pathophysiology II ,[object Object],[object Object],[object Object],[object Object]
Importance of Vasopressin ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Vasopressin and GFR ,[object Object],[object Object],[object Object],[object Object]
Effects of Systemic Arterial Vasodilation on Starling forces ,[object Object],[object Object],[object Object]
Effects of systemic arterial vasodilatation (cont.’d) ,[object Object],[object Object],[object Object]
Excessive fluid administration in the setting of Sepsis and ARF ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Experimental models of Sepsis induced ARF ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Benefits of Early Fluid Resuscitation ,[object Object],[object Object],[object Object],[object Object],[object Object]
Glucose Control ,[object Object],[object Object]
Benefits Glucorticoids ,[object Object],[object Object],[object Object]
 
Renal Replacement Therapy ,[object Object],[object Object]
Peak Concentration Hypothesis
Renal Replacement Therapy ,[object Object],[object Object]
Conclusions ,[object Object],[object Object],[object Object]

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