Presented by: Stephen Onufrak, PhD, Antonio Bellasi, MD, Francesca Cardarelli, MD, Viola Vaccarino, MD, PhD, Paolo Raggi, MD

1. Phosphorus levels are associated with subclinical atherosclerosis in the general population. Stephen Onufrak, PhD, Antonio Bellasi, MD, Francesca Cardarelli, MD, Viola Vaccarino, MD, PhD, Paolo Raggi, MD Emory University School of Medicine, Atlanta, GA

5. Copyright ©2005 American Heart Association Tonelli, M. et al. Circulation 2005;112:2627-2633 Fully adjusted risk of clinical outcomes by baseline serum phosphate

11. Subject Characteristics According to Serum Phosphorus Level <0.01 306.3 304.1 299.5 297.8 297.4 Fibrinogen 0.59 92.6 92.6 92.0 92.6 92.0 Est. GFR <0.01 222.1 216.2 215.5 210.8 209.5 T. Cholesterol <0.01 33.0 27.8 25.7 22.9 21.4 Current Smoke% 0.04 32.3 31.9 31.5 31.0 34.6 Hypertension % 0.02 11.5 9.6 9.0 9.2 10.6 Diabetes % 0.07 26.2 25.2 25.6 23.8 23.3 Black Race % <0.01 79.9 68.5 57.8 47.2 33.4 Female % 0.02 54.3 54.1 53.9 53.9 53.9 Age >3.8 3.6-3.8 3.4-3.5 3.1-3.3 <3.0 p-value Serum Phosphorus (mg/dL)

12. Evaluation of Heterogeneity of Effect 0.18 Diabetes 0.24 Serum Calcium 0.60 Current Smoking 0.31 Total Cholesterol 0.70 Age 0.39 Kidney Function 0.04 Race 0.0007 Gender Interaction p -value Stratification Variable

13. Trend Test: p <0.0001

14. Trend Test: p =0.009

15. Adjusted for age, race, diabetes, hypertension, total cholesterol, HDL, eGFR, and smoking status Trend Test: p <0.0001

16. Adjusted for age, race, diabetes, hypertension, total cholesterol, HDL, eGFR, and smoking status Trend Test: p =0.19