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Gene Therapy;Boon Or Adversary To Humanity

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shahnawaz ahmad bhat
Saúde e medicinaTecnologia
1 de 58
GENE THERAPY; Boon or adversary to humanity Dr. shahnawaz Ah. Bhat MVSc scholar IVRI Izatnagar India
Genes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
What is Gene Therapy? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
How It Works ,[object Object],[object Object]
[object Object],[object Object],[object Object]
Types of Gene Therapy ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
Methods adopted ,[object Object]
[object Object]
Vectors for gene therapy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
A comparison of different viral vectors in use for gene therapy
Retroviral vectors ,[object Object],[object Object],[object Object]
Adenoviral Vectors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Adeno-Associated Viral Vectors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Herpes virus es ,[object Object],[object Object],[object Object]
Risk Factors associated with viruses . ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object]
Non-Viral Vectors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
[object Object],[object Object],[object Object],[object Object]
Oligonucleotides ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
Use of siRNA Dicer is an endoribonuclease that cleaves double-stranded RNA (dsRNA) into short double-stranded RNA fragments called small interfering RNA(siRNA) about 20-25 nucleotides long, initiates formation of the RNA-induced silencing complex (RISC), whose catalytic component is an endonuclease capable of degrading messenger RNA (mRNA) whose sequence is complementary to that of the siRNA guide strand .
 
Lipoplexes/liposomes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
Polyplexes ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
Dendrimers ,[object Object],[object Object],[object Object],[object Object]
 
The Beginning… ,[object Object],[object Object],[object Object],[object Object]
The First Case……. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
What they did….. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Failures……… ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object]
Success story…….. ,[object Object],[object Object]
[object Object],[object Object]
[object Object]
[object Object],[object Object]
 
[object Object],[object Object]
Future prospects…..
 
Gene therapy in India……… ,[object Object],[object Object],[object Object],[object Object]
Problems with Gene Therapy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Ethical issues surrounding gene therapy ,[object Object],[object Object],[object Object],[object Object],[object Object]
Conclusion ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Thanks

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Gene Therapy;Boon Or Adversary To Humanity

  • 1. GENE THERAPY; Boon or adversary to humanity Dr. shahnawaz Ah. Bhat MVSc scholar IVRI Izatnagar India
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  • 13. A comparison of different viral vectors in use for gene therapy
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  • 29. Use of siRNA Dicer is an endoribonuclease that cleaves double-stranded RNA (dsRNA) into short double-stranded RNA fragments called small interfering RNA(siRNA) about 20-25 nucleotides long, initiates formation of the RNA-induced silencing complex (RISC), whose catalytic component is an endonuclease capable of degrading messenger RNA (mRNA) whose sequence is complementary to that of the siRNA guide strand .
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