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Dr. Mohamed Al-Shekhani.
Pathophysiology of DM.
Dual Metabolic Abnormalities in T2DM
Excessive
Hepatic Glucose
Output
Decreased
Glucose Uptake
Insulin DeficiencyInsulin Resistance
Decreased
Insulin
Secretion
Unrestrained
Lipolysis
Treatment:
• Diet/Exercise: both types
• TIDM: Insulin.
• T2DM: Oral hypoglycemic drugs +/- insulin.
Stepwise Management of T2 DM
Insulin ± oral agents
Oral combination
Oral monotherapy
Diet & exercise
What’s Your Message?THANKS

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Pathophysiology DM.

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