Acromegaly 19.07.08

Wound Healing The Basic Principles

Wound healing Day 21 - 2yrs Remodelling Contracture Day 4 - 21 Proliferation Granulation Day 1 - 4 Inflammation Immediate Haemostasis Days post injury Phase of healing

Haemostasis ,[object Object],[object Object],[object Object],[object Object]

Inflammatory phase ,[object Object],[object Object],[object Object]

Proliferative phase (4 – 21 days) ,[object Object],[object Object],[object Object],[object Object]

Remodelling or Maturation phase ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Platelets ,[object Object],[object Object],[object Object],[object Object],[object Object]

Neutrophils ,[object Object],[object Object],[object Object],[object Object],[object Object]

Monocytes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Lymphocytes ,[object Object],[object Object],[object Object],[object Object]

Fibroblast ,[object Object],[object Object],[object Object],[object Object],[object Object],Extracellular matrix

Angiocytes ,[object Object],[object Object],[object Object]

Keratinocytes ,[object Object],[object Object],[object Object],[object Object],[object Object]

Healing responses Haemostsis Inflammation Proliferation Immediate Day 1 - 4 Day 4 - 21 Platelets Neutrophils Macrophages Lymphocyte Fibroblast Framers Contracture Angiocyte Plumber Keratinocytes Roofers & siders Utility worker Unskilled workers Contractor Asst. Contractor Remodeling Day 21–2 yrs Fibrocytes Remodelers

Matrix ,[object Object],[object Object],[object Object]

Matrix contd. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Matrix contd. ,[object Object],[object Object],[object Object]

Fibronectin ,[object Object],[object Object],[object Object]

Collagen ,[object Object],[object Object],[object Object],[object Object],[object Object]

Collagen contd. ,[object Object],[object Object],[object Object]

Matrix metalloproteases ,[object Object],[object Object],[object Object],[object Object],[object Object]

Factors affecting wound healing ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Systemic factors ,[object Object],[object Object],[object Object],[object Object]

Nutrition & wound healing ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],Fats

Proteins ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],Amino acids

Arginine ,[object Object],[object Object],[object Object],[object Object]

Vitamins ,[object Object],[object Object],[object Object],[object Object],[object Object]

Vitamins ,[object Object],[object Object],[object Object]

Micronutrients ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Iron ,[object Object],[object Object],[object Object],[object Object]

Diabetes Mellitus ,[object Object],[object Object],[object Object],[object Object],[object Object]

Tissue ischemia ,[object Object],[object Object],[object Object],[object Object]

Wound debridement ,[object Object],[object Object]

Types of wound healing ,[object Object],[object Object],[object Object]

Ideal wound dressing ,[object Object],[object Object],[object Object],[object Object],[object Object]

Ideal wound dressing – contd. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Occlusive wound dressing ,[object Object],[object Object],[object Object],[object Object],[object Object]

Advantages of occlusive dressings ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Non biologic occlusive dressing ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Biologic Occlusive Dressing ,[object Object],[object Object],[object Object],[object Object]

Acromegaly 19.07.08

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