Biological Activity of 17-DMAG: 17-DMAG, a watersoluble geldanamycin analog belonging to the class of benzoquinones, is a selective Hsp90 inhibitor. 17-DMAG binds to the N-terminal domain ATP binding site of Hsp90, inhibiting Hsp90 chaperone activity. 17-DMAG demonstrates greater potency and water solubility than other geldanamycin analogs such as 17-AAG (mean GI50 values are 53 and 123 nM for 17-DMAG and 17-AAG respectively), while demonstrating anti-tumor activity and offering excellent oral bioavailability. [1] -------------------------------------------------------------------------------- References on 17-DMAG: [1] Smith V et al. Cancer Chemother Pharmacol. 2005 Aug;56(2):126-37

1. Product Information Novel Kinase Inhibitors
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M.Wt: 653.21 H
O
N
N
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Formula: C32H48N4O8•HCl HCl
CH 3
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N
Solubility: DMSO
H
O
H 3C H
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H 3CO
O
Purity: 99% H 3CO CH 3
H 3C tech@selleckchem.com
Storage: at -20℃ 2 years OCONH 2
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CAS No.: 467214-21-7 Synonyms: Alvespimycin, KOS-1022 techbio@selleckchem.com
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Biological Activity
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17-DMAG, a watersoluble geldanamycin analog belonging to the class of benzoquinones, is a
selective Hsp90 inhibitor. 17-DMAG binds to the N-terminal domain ATP binding site of Hsp90,
inhibiting Hsp90 chaperone activity. 17-DMAG demonstrates greater potency and water solubility
than other geldanamycin analogs such as 17-AAG (mean GI50 values are 53 and 123 nM for 17-DMAG
and 17-AAG respectively), while demonstrating anti-tumor activity and offering excellent oral
bioavailability. [1]
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References
[1] Smith V et al. Cancer Chemother Pharmacol. 2005 Aug;56(2):126-37
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