1. Pre-Commercialized
Commercialization of R&D Products
Research Management Centre
RESEARCHERS:
Nurhafzan Anis binti Ismail
nurhafzan@cepp.utm.my or nurhafzan@yahoo.com
Saiful Irwan bin Zubairi
Chemical Engineering Pilot Plant (CEPP)
Universiti Teknologi Malaysia
Tel: +607- 553 1665
Fax: +607- 556 9706
9.5 cm
5.5 cm
*15 g active ingredient per sachet
Product Prototype of
Fever-Coolant™ Sachet
Product Prototype Label of
Fever-Coolant™ Sachet FEVER-COOLANT™
Efficacy of total heat transfer, ε: 86.2 %
DISPERSE HEAT; Q (1.88 J) SACHET
t∞ (1800 s); T∞ (37 0C)
ABSORBENT PAD
t0 (0 s); T0 (38 0C)
ABSORB HEAT FROM FOREHEAD
Heat transfer mechanism Hibiscus rosa-sinensis leaves
(Newtonian method/Cooling method)
Product Features
• The novel feature of this invention is to stabilize fluctuating body temperature during fever via external heat transfer (surface
convective) using the natural plant-based formulation, which involves the negative feedback mechanism.
• Hibiscus rosa-sinensis Linn leaves consist of taraxeryl acetate, β-sitosterol, high calcium and phosphorus contents. Hence, the
synergistic of these compounds contributes to the antipyretic activity.
• Modern antipyretic drugs (e.g.: paracetamol) are associated with hepatotoxicity. Thus, the Fever-Coolant™ Sachet is an alternative of
allopathic remedy to reduce fever especially in infants and children as it is derived from non toxic natural plant.
• This product is a water-based leaves extract which undergo a freeze dried method, where the active ingredients and minerals are very
well preserved. Therefore, the efficacy and safety of the product is ensured and it is obviously very practical for the household use.
Awards
• Bronze Medal - Malaysia Technology Expo (MTE) 2006
©2006 Research Management Centre. All rights reserved. RMC06/O031