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Vaccines for preventing influenza in healthy adults: a Cochrane review Clinical www.cochranejournalclub.com
Clinical question ,[object Object],www.cochranejournalclub.com Source:  Jefferson T, Di Pietrantonj C, Rivetti A, Bawazeer GA, Al-Ansary LA, Ferroni E.  Vaccines for preventing influenza in healthy adults .  Cochrane Database of Systematic Reviews  2010, Issue 7. Art. No.: CD001269. DOI: 10.1002/14651858.CD001269.pub4.
Context ,[object Object],[object Object],[object Object],[object Object],www.cochranejournalclub.com
Methods ,[object Object],[object Object],[object Object],www.cochranejournalclub.com
PICO(S)  to assess eligible studies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.cochranejournalclub.com
Description of eligible studies ,[object Object],[object Object],[object Object],[object Object],www.cochranejournalclub.com
Results: inactivated influenza vaccines ,[object Object],[object Object],www.cochranejournalclub.com
www.cochranejournalclub.com Efficacy of influenza vaccine in healthy adults (vaccine content completely matching circulating strain) Based on 8 clinical trials, 11,285 participants   100 healthy adults,  vaccinated 100 healthy adults,  not vaccinated 1 develops influenza 4 develop influenza
www.cochranejournalclub.com Efficacy of influenza vaccine in healthy adults (vaccine content incompletely matching circulating strain or not reported) Based on 6 clinical trials with 10,331 participants 100 healthy adults,  vaccinated 100 healthy adults,  not vaccinated 1 develops influenza 2 develop influenza
Results: systemic adverse effects ,[object Object],[object Object],[object Object],[object Object],www.cochranejournalclub.com
Results: other outcomes ,[object Object],[object Object],[object Object],www.cochranejournalclub.com
Results: local harms ,[object Object],[object Object],www.cochranejournalclub.com
Conclusions ,[object Object],[object Object],[object Object],www.cochranejournalclub.com
www.cochranejournalclub.com How many influenza-like illnesses a year? How many of these are influenza? Based on 274 studies of influenza vaccines and 28 epidemiological studies from 1966 to 2007, with more than 3,000,000 participants 100 people 7 people with flu episodes (only 1 has influenza) Influenza A or B
Useful links ,[object Object],[object Object],www.cochranejournalclub.com

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Vaccines for-preventing-influenza-clinical

  • 1. Vaccines for preventing influenza in healthy adults: a Cochrane review Clinical www.cochranejournalclub.com
  • 2.
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  • 7.
  • 8. www.cochranejournalclub.com Efficacy of influenza vaccine in healthy adults (vaccine content completely matching circulating strain) Based on 8 clinical trials, 11,285 participants 100 healthy adults, vaccinated 100 healthy adults, not vaccinated 1 develops influenza 4 develop influenza
  • 9. www.cochranejournalclub.com Efficacy of influenza vaccine in healthy adults (vaccine content incompletely matching circulating strain or not reported) Based on 6 clinical trials with 10,331 participants 100 healthy adults, vaccinated 100 healthy adults, not vaccinated 1 develops influenza 2 develop influenza
  • 10.
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  • 14. www.cochranejournalclub.com How many influenza-like illnesses a year? How many of these are influenza? Based on 274 studies of influenza vaccines and 28 epidemiological studies from 1966 to 2007, with more than 3,000,000 participants 100 people 7 people with flu episodes (only 1 has influenza) Influenza A or B
  • 15.