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ZRANB2 —
                         a transcriptional
                             regulator?
                              Richard P. Grant
                               MMB, Sydney




Thursday, 11 September 2008                      1
Splicing
                 • Splicing ubiquitous in eukaryotes
                 • ~70% human genes are alternatively spliced
                 • Aberrant splicing causes genetic disease, e.g.
                          - DMD
                          - CF




Thursday, 11 September 2008                                         2
Consensus sequences
                                 direct splicing


           Exon 1                  Intron 1–2   Exon 2




Thursday, 11 September 2008                              3
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ZRANB2

  • 1. ZRANB2 — a transcriptional regulator? Richard P. Grant MMB, Sydney Thursday, 11 September 2008 1
  • 2. Splicing • Splicing ubiquitous in eukaryotes • ~70% human genes are alternatively spliced • Aberrant splicing causes genetic disease, e.g. - DMD - CF Thursday, 11 September 2008 2
  • 3. Consensus sequences direct splicing Exon 1 Intron 1–2 Exon 2 Thursday, 11 September 2008 3