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Amelioration of Metabolic Acidosis and Progression of CKD (Journal Club)
1. Raj Kiran Medapalli, MD, MPH. Nephrology Fellow July 28th, 2010 Mount Sinai School of Medicine Division of Nephrology Journal Club
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28. At 30 months: NaCit vs. No-NaCit: 107.1±48.7 vs 146.9 ±44.6 mg/g Cr; p=0.002
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33. Shah, Hostetter et al. AJKD 2009 Aug; 54(2): 270-277 Low serum bicarbonate levels have been shown to be associated with progression of kidney disease independent of baseline eGFR and other clinical, demographic, and socioeconomic factors.
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Notas do Editor
Normally, after a dietary acid load there is distal nephron acidification (increased H+ secretion & decreased HCO3 secretion in DCT, resulting in decreased HCO3 delivery to terminal distal nephron, -> increased titration of non-HCO3 buffers).