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KEEPING
     ABREAST



         Therapeutic choices for the
    treatment of lactational mastitis.
Valerie Rzepka, NP-PHC Student
Nellie Turner
History of Presenting Illness:            31 years old
• Mid-October, presented at ER                 (pseudonym)
  with:
 •   right breast engorgement
 •   erythema
 •   Firmness
 •   edema
 •   generalized malaise
 •   fever
 •   chills
• Treated for lactational mastitis
  with Cephalexin 500mg po, qid x
  10 days
• Returned after completion of
  antibiotics   for     continued
  unresolved symptoms.
• Cephalexin extended for 5 days.
• Returned 1 week later with
  continued,           unresolved
  symptoms
Nellie Turner
Past Medical History                           31 years old
                                                    (pseudonym)
• Nellie reports her health to be
  quite good:
 • Planned pregnancy, previously used
   NuvaRing for contraception.
 • Mild anemia during pregnancy
 • Mild eczema in the winter months,
 • Occasional migraines
 • Chronic neck and back pain
   secondary to MVC in 1996
 • Deviated nasal septum – ENT Surgery
   deferred due to pregnancy.
 • No chronic medical conditions,
 • No known allergies,
 • She denies weight loss and change in
   diet.
 • Reports significant change in her
   energy, activity level and sleep
   pattern since the onset of the
   infection.
Nellie Turner
Past Medical History
                                         31 years old
                                              (pseudonym)
• Gravida 1, Para 1. Followed by
  Nottawasaga Midwives for this
  unremarkable first pregnancy.
• Spontaneous Vaginal Delivery of
  a healthy baby boy at 38 weeks
  gestation on July 10, 2012.
• Baby is solely breastfed every
  three to four hours or on
  demand.
• Aside from cracked nipples,
  treated with a lanolin-based
  over-the-counter ointment, has
  had no issues with lactation,
  latch or suck.
Nellie Turner
                                             31 years old
 Baby Jonah (pseudonym)                           (pseudonym)

 • Baby born via SVD, weight: 3620g.
   (7.9lbs)
 • Satisfactorily growing and gaining
   weight according to the growth
   chart.
 • Currently          4       months
   old, active, alert, and is meeting
   all    of     his    developmental
   milestones.
 • Feeds every 3 to 4 hours, and has
   6 to 7 heavy wet diapers per
   day, along with 2 to 3 yellow
   seedy stools.
• Since initiation of antibiotics in
  October, Nellie reports Jonah
  has been having loose green
  stools, but no other ill effects.
Engorgement    Erythema


                              Edema
Firmness


                              Generalized
                              Malaise

   Chills
                  Fever

    Diagnosis: Lactational Mastitis5
• Inflammatory condition of the breast3,5
• May or may not be accompanied by infection.1,3.
• Usually associated with lactation, so it is also called
  “lactational mastitis”1
• Occurs in 9-12% of all breastfeeding women2,3,4,5
• Most common in the 2nd or 3rd week of
  breastfeeding, but can occur at any time. 2,5
• Usually associated with Staphylococcus aureus (S.
  aureus), introduced through a break in the skin
  (cracked nipple), which characteristically can also
  cause abscess development.4
• Nellie reports having cracked nipples in the week
  prior to the infection.
• Risk Factors associated with Mastitis:5
 •   Cleft lip or palate
 •   Cracked nipples
 •   Infant attachment difficulties
 •   Local milk stasis
 •   Missed feedings
 •   Nipple piercing
 •   Plastic-backed breast pads
 •   Poor maternal nutrition
 •   Previous mastitis
 •   Primiparity
 •   Restriction from a tight bra
 •   Short frenulum in infant
 •   Sore nipples
 •   Use of a manual breast pump
 •   Yeast infection
#1 Cause of mastitis:
     Milk Stasis1
1. To provide prompt and effective
   treatment so to prevent complications
   such as an abscess.
2. To provide effective pain relief.
3. To encourage continued
   breastfeeding.
Non-Pharmacological
• Improved breastfeeding technique/ alternative positions. 5
• Continuation of breastfeeding, especially on affected breast, as often as
  possible.
   • Milk from a breast with mastitis contains increased levels of some anti-inflammatory
     components that may be protective for the infant.
   • Some infants may dislike the taste of milk from the infected breast, possibly because of
     the increased sodium content.5
   • Holding the infant with the chin towards the affected part of the breast, helps to
     facilitate milk removal from that section
• Apply heat: warm compresses, warm bath or shower;
• Gentle massage of any lumpy areas while the infant is feeding to help the
  milk to flow
• Avoid anything that could obstruct the flow of milk, such as tight clothes or
  bra
• Mom should drink plenty of fluids and get lots of rest 5
• Application of Cabbage Leaves 17 or Sliced Potatoes 16 to the breast have no
  scientifically proven efficacy, but anecdotal reports are supportive.
Non-Pharmacological –
Lactation Consultation and Counselling
• Mastitis is painful and frustrating, makes many women
  feel very ill, and can leave infants unsatisfied after
  feeding.
• In addition to effective treatment and control of pain,
  a woman needs emotional support.
• May have received conflicting advice from
  professionals, family members or friends. May have
  been advised to stop breastfeeding, or given no
  guidance either way. May be confused and anxious,
  and unwilling to continue breastfeeding.
• Needs reassurance about value of breastfeeding; it is
  safe to continue; milk from the affected breast will not
  harm infant, and that breast will recover both its
  shape and function subsequently.
• Needs encouragement
• Needs clear guidance about all measures needed for
  treatment, and how to continue breastfeeding or
  expressing milk from the affected breast.
• Will need follow up to give continuing support and
  guidance until she has recovered fully.
Non-Pharmacological
Mastitis                  Adapted from: Mastitis Lactational Algorithm
                                   http://www.thewomens.org.au/MastitisLactationalAlgorithm



Heat, rest and drain the                   24 hrs
breast
•   Keep feeding frequently
•   Heat before feeds
•   Massage during feeds
•   Analgesia (Tylenol or Advil)
                                     No                            Pharmacological
          Generalized                                                Alternatives
      symptoms present?
        •   Fever
        •   Aches
        •   Lethargy

                                   Yes
Pharmacological                         Commence
      Alternatives                          Antibiotics



                                                              If no overall
                                                             improvement
                                               Redness/
                                                              in 48 hours,
                                             hard after 5
                                                                return to
      If improving:                              days:
                                                                  clinic.
        Complete                               Continue
         course of                            antibiotics
       antibiotics.                            x 10 days
                                                                    Milk for
                                                 Ultra               C&S
                                                sound
                                                to r/o
                                               abscess
                                                            Refer/ Admission
Adapted from: Mastitis Lactational Algorithm                   for IV Abx
http://www.thewomens.org.au/MastitisLactationalAlgorithm
Pharmacological

• Antibiotic treatment is indicated if either:
 • cell and bacterial colony counts and culture are available and indicate
   infection, or
 • a nipple fissure is visible, or
 • symptoms do not improve after 12-24 hours of improved milk removal, or
 • symptoms are severe from the beginning.
Pharmacological : 5, 7,9, 10, 11, 12, 13, 14, 15
 •   Amoxicillin/clavulanate, (AmoxiClav) 875 mg twice daily
 •   Cephalexin, (Keflex), 500 mg four times daily
 •   Ciprofloxacin, (Cipro), 500 mg twice daily
 •   Clindamycin, (Biaxin), 300 mg four times daily
 •   Cloxacillin, 500 mg four times daily
 •   Trimethoprim/sulfamethoxazole (Bactrim, Septra), 160 mg/800 mg twice
     daily


Usual courses of oral antibiotics are 10 to 14 days.
If patient wishes to continue breastfeeding, safety of the infant
must be considered.
Nellie Turner
                                                                         31 years old
                                                                                       (pseudonym)


Prescription Drug Name etc.           Dose, Route, Freq, Duration   Rating (1-5)       NP   Pick
                                                                    C A S E S
Amoxicillin/clavulanate,              875 mg, bid x 10 days         4 1 4          1   ✓
(Clavulin)
Cephalexin,                           500 mg, qid x 10 days         4 5 3 1 5 ✓              ✓
(Keflex)
Ciprofloxacin,                        500 mg bid x 10 days          4 1 5          1   ✓
(Cipro)
Cloxacillin                           500 mg qid x 10 days          4 5 3 2 5 ✓
Trimethoprim/ sulfamethoxazole        160 mg/800 mg bid x 10        1 1 1 3 1          ✓     ✓
(Bactrim, Septra)                     days
Ref: 5, 7,9, 10, 11, 12, 13, 14, 15
Nellie Turner
                                                        31 years old
Consultation – Collaborating physician 10:                      (pseudonym)

• Nellie returned after her 10-day course of Cephalexin 500mg qid with
  unresolved symptoms
• Cephalexin was extended for 5 days, and Nellie was ordered a breast
  ultrasound
• She returned again once antibiotics were complete, with continued
  unresolved symptoms. Ultrasound was clear.
• Collaborating physician was consulted, and recommended a course of
  Trimethoprim/ Sulfamethoxazole 160/800mg bid x 10 days.
Referral10 - General Surgery:
 •   if ultrasound shows breast abscess;
 •   for needle aspirate, or incision and drainage of abscess.
Nellie Turner
                                                          31 years old
                                                               (pseudonym)
       The Therapeutic I Community Health Centre
     123 University Avenue, Anytown, ON. N0N 0N0
                  Phone 416-321-0987
_________________________________________________
Name: Nellie Turner (DOB: January 1, 1981, NKDA)
Address: 1000 Fantasy Lane, Anytown, ON. L0R1B0




Date: November 22, 2012

    Trimethoprim/ sulfamethoxazole 160 mg/800 mg
                     bid x 10 days.

  Take one tablet by mouth, twice daily until finished.

M: 20 tabs
R: 0 repeats



    Nancy Nurse RN (EC), 54321 (signed)
                  Nancy Nurse, RN (EC), 54321 (printed)
Nellie Turner
Monitoring and Follow up
                                                 31 years old
                                                     (pseudonym)

• Important to monitor baby Jonah to signs of
   dehydration, or secondary infection (e.g. thrush)
• Client returned after the 10-day course of, reporting
   that symptoms have nearly entirely resolved, her
   energy level had returned, and the erythema and had
   engorgement had disappeared.
• The painful, firm thickening has nearly completely
   resolved.
Acceptability
• Client was satisfied with resolution, happy to return to
  normal functioning, and glad that Baby Jonah continued
  to do well.
1.   WorldHealthOrganization. (2000). Mastitis: Causes and management. Geneva:WHO.
     Retrieved from:
     http://www.who.int/maternal_child_adolescent/documents/fch_cah_00_13/en/
2.   Foxman, B., D'Arcy, H., Gillespie, B., Bobo, J. K., & Schwartz, K. (2002). Lactation
     Mastitis: Occurrence and Medical Management among 946 Breastfeeding Women
     in the United States. American Journal of Epidemiology 155(2) pp. 103-114.
3.   Jahanfar S, Ng CJ, Teng CL. (2009). Antibiotics for mastitis in breastfeeding women.
     Cochrane Database of Systematic Reviews 1.
4.   Amir, L.H., Forster, D., McLachlan, H., & Lumley J. (2004). Incidence of breast
     abscess in lactating women: report from an Australian cohort. BJOG: an
     International Journal of Obstetrics and Gynaecology 111. pp. 1378–1381
5.   Spencer, J. (2008). Management of mastitis in breastfeeding women. American
     family physician. 78 (6). PP.727-732.
6.   The Royal Womens’ Hospital. (2012). Mastitis: lactational (algorithm). Parkville, VIC.
     Australia. Retrieved from:
     http://www.thewomens.org.au/MastitisLactationalAlgorithm.
7.   Lawrence R.A., & Lawrence, R.M. (2011). Breastfeeding: A Guide for the Medical
     Professions. 7th ed,. Maryland Heights, MO: Elsevier Mosby.
8.   Academy of Breastfeeding Medicine Protocol Committee (ABMPC). Berens, P. (ed).
     (2009) ABM clinical protocol #20: engorgement. Breastfeed Med 4(2):pp. 111-3.
     Retrieved from:
     http://www.guideline.gov/content.aspx?id=15183&search=Pumps%2C+Breast +
9.    National Library of Medicine. Toxicology Data Network (TOXNET). *2011)
      Trimethoprim-sulfamethoxazole. Drug and Lactation Database (LACTMED).
      Retrieved from: http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~vP0pfa:1.
10. Clavulin. [CPhA Drug Monograph]. Retrieved from e-Therapeutics+: e-CPS:
    https://www.e-therapeutics.ca/cps.showMonograph.action
11.   Sulfamethoxazole-Trimethoprim [CPhA Drug Monograph]. Retrieved from e-
      Therapeutics+: e-CPS: https://www.e-
      therapeutics.ca/cps.select.preliminaryFilter.action?simplePreliminaryFilter=sulfamet
      hoxazole#
12.   Cephalexin. [CPhA Drug Monograph]. Retrieved from e-Therapeutics+: e-CPS:
      https://www.e-
      therapeutics.ca/cps.select.preliminaryFilter.action?simplePreliminaryFilter= cephalex
      in
13. Ciprofloxacin. [CPhA Drug Monograph]. Retrieved from e-Therapeutics+: e-CPS:
    https://www.e-
    therapeutics.ca/cps.select.preliminaryFilter.action?simplePreliminaryFilter= ciproflox
    acin
14. Cloxacillin.. [CPhA Drug Monograph]. Retrieved from e-Therapeutics+: e-CPS:
    https://www.e-
    therapeutics.ca/cps.showMonograph.action?simpleQuery=Cloxacillin% 20
15. College of Nurses of Ontario. (2011). Practice Standards: Nurse Practitioner Revised
    2011. Toronto, ON: Author.
16. Newman Breastfeeding Centre. (2009). Blocked ducts and mastitis. Retrieved from:
    http://www.nbci.ca/index.php?option=com_content&view=article&id=7:blocked-
    ducts-a-mastitis&catid=5:information&Itemid=17
17.   Mangesi L, Dowswell T. (2010). Treatments for breast engorgement during lactation
      (Review) The Cochrane Library. 9

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Rzepka, v therapeutics 1 mastitis presentation

  • 1. KEEPING ABREAST Therapeutic choices for the treatment of lactational mastitis. Valerie Rzepka, NP-PHC Student
  • 2. Nellie Turner History of Presenting Illness: 31 years old • Mid-October, presented at ER (pseudonym) with: • right breast engorgement • erythema • Firmness • edema • generalized malaise • fever • chills • Treated for lactational mastitis with Cephalexin 500mg po, qid x 10 days • Returned after completion of antibiotics for continued unresolved symptoms. • Cephalexin extended for 5 days. • Returned 1 week later with continued, unresolved symptoms
  • 3. Nellie Turner Past Medical History 31 years old (pseudonym) • Nellie reports her health to be quite good: • Planned pregnancy, previously used NuvaRing for contraception. • Mild anemia during pregnancy • Mild eczema in the winter months, • Occasional migraines • Chronic neck and back pain secondary to MVC in 1996 • Deviated nasal septum – ENT Surgery deferred due to pregnancy. • No chronic medical conditions, • No known allergies, • She denies weight loss and change in diet. • Reports significant change in her energy, activity level and sleep pattern since the onset of the infection.
  • 4. Nellie Turner Past Medical History 31 years old (pseudonym) • Gravida 1, Para 1. Followed by Nottawasaga Midwives for this unremarkable first pregnancy. • Spontaneous Vaginal Delivery of a healthy baby boy at 38 weeks gestation on July 10, 2012. • Baby is solely breastfed every three to four hours or on demand. • Aside from cracked nipples, treated with a lanolin-based over-the-counter ointment, has had no issues with lactation, latch or suck.
  • 5. Nellie Turner 31 years old Baby Jonah (pseudonym) (pseudonym) • Baby born via SVD, weight: 3620g. (7.9lbs) • Satisfactorily growing and gaining weight according to the growth chart. • Currently 4 months old, active, alert, and is meeting all of his developmental milestones. • Feeds every 3 to 4 hours, and has 6 to 7 heavy wet diapers per day, along with 2 to 3 yellow seedy stools. • Since initiation of antibiotics in October, Nellie reports Jonah has been having loose green stools, but no other ill effects.
  • 6. Engorgement Erythema Edema Firmness Generalized Malaise Chills Fever Diagnosis: Lactational Mastitis5
  • 7. • Inflammatory condition of the breast3,5 • May or may not be accompanied by infection.1,3. • Usually associated with lactation, so it is also called “lactational mastitis”1 • Occurs in 9-12% of all breastfeeding women2,3,4,5 • Most common in the 2nd or 3rd week of breastfeeding, but can occur at any time. 2,5 • Usually associated with Staphylococcus aureus (S. aureus), introduced through a break in the skin (cracked nipple), which characteristically can also cause abscess development.4 • Nellie reports having cracked nipples in the week prior to the infection.
  • 8. • Risk Factors associated with Mastitis:5 • Cleft lip or palate • Cracked nipples • Infant attachment difficulties • Local milk stasis • Missed feedings • Nipple piercing • Plastic-backed breast pads • Poor maternal nutrition • Previous mastitis • Primiparity • Restriction from a tight bra • Short frenulum in infant • Sore nipples • Use of a manual breast pump • Yeast infection
  • 9. #1 Cause of mastitis: Milk Stasis1
  • 10. 1. To provide prompt and effective treatment so to prevent complications such as an abscess. 2. To provide effective pain relief. 3. To encourage continued breastfeeding.
  • 11. Non-Pharmacological • Improved breastfeeding technique/ alternative positions. 5 • Continuation of breastfeeding, especially on affected breast, as often as possible. • Milk from a breast with mastitis contains increased levels of some anti-inflammatory components that may be protective for the infant. • Some infants may dislike the taste of milk from the infected breast, possibly because of the increased sodium content.5 • Holding the infant with the chin towards the affected part of the breast, helps to facilitate milk removal from that section • Apply heat: warm compresses, warm bath or shower; • Gentle massage of any lumpy areas while the infant is feeding to help the milk to flow • Avoid anything that could obstruct the flow of milk, such as tight clothes or bra • Mom should drink plenty of fluids and get lots of rest 5 • Application of Cabbage Leaves 17 or Sliced Potatoes 16 to the breast have no scientifically proven efficacy, but anecdotal reports are supportive.
  • 12. Non-Pharmacological – Lactation Consultation and Counselling • Mastitis is painful and frustrating, makes many women feel very ill, and can leave infants unsatisfied after feeding. • In addition to effective treatment and control of pain, a woman needs emotional support. • May have received conflicting advice from professionals, family members or friends. May have been advised to stop breastfeeding, or given no guidance either way. May be confused and anxious, and unwilling to continue breastfeeding. • Needs reassurance about value of breastfeeding; it is safe to continue; milk from the affected breast will not harm infant, and that breast will recover both its shape and function subsequently. • Needs encouragement • Needs clear guidance about all measures needed for treatment, and how to continue breastfeeding or expressing milk from the affected breast. • Will need follow up to give continuing support and guidance until she has recovered fully.
  • 14. Mastitis Adapted from: Mastitis Lactational Algorithm http://www.thewomens.org.au/MastitisLactationalAlgorithm Heat, rest and drain the 24 hrs breast • Keep feeding frequently • Heat before feeds • Massage during feeds • Analgesia (Tylenol or Advil) No Pharmacological Generalized Alternatives symptoms present? • Fever • Aches • Lethargy Yes
  • 15. Pharmacological Commence Alternatives Antibiotics If no overall improvement Redness/ in 48 hours, hard after 5 return to If improving: days: clinic. Complete Continue course of antibiotics antibiotics. x 10 days Milk for Ultra C&S sound to r/o abscess Refer/ Admission Adapted from: Mastitis Lactational Algorithm for IV Abx http://www.thewomens.org.au/MastitisLactationalAlgorithm
  • 16. Pharmacological • Antibiotic treatment is indicated if either: • cell and bacterial colony counts and culture are available and indicate infection, or • a nipple fissure is visible, or • symptoms do not improve after 12-24 hours of improved milk removal, or • symptoms are severe from the beginning.
  • 17. Pharmacological : 5, 7,9, 10, 11, 12, 13, 14, 15 • Amoxicillin/clavulanate, (AmoxiClav) 875 mg twice daily • Cephalexin, (Keflex), 500 mg four times daily • Ciprofloxacin, (Cipro), 500 mg twice daily • Clindamycin, (Biaxin), 300 mg four times daily • Cloxacillin, 500 mg four times daily • Trimethoprim/sulfamethoxazole (Bactrim, Septra), 160 mg/800 mg twice daily Usual courses of oral antibiotics are 10 to 14 days. If patient wishes to continue breastfeeding, safety of the infant must be considered.
  • 18. Nellie Turner 31 years old (pseudonym) Prescription Drug Name etc. Dose, Route, Freq, Duration Rating (1-5) NP Pick C A S E S Amoxicillin/clavulanate, 875 mg, bid x 10 days 4 1 4 1 ✓ (Clavulin) Cephalexin, 500 mg, qid x 10 days 4 5 3 1 5 ✓ ✓ (Keflex) Ciprofloxacin, 500 mg bid x 10 days 4 1 5 1 ✓ (Cipro) Cloxacillin 500 mg qid x 10 days 4 5 3 2 5 ✓ Trimethoprim/ sulfamethoxazole 160 mg/800 mg bid x 10 1 1 1 3 1 ✓ ✓ (Bactrim, Septra) days Ref: 5, 7,9, 10, 11, 12, 13, 14, 15
  • 19. Nellie Turner 31 years old Consultation – Collaborating physician 10: (pseudonym) • Nellie returned after her 10-day course of Cephalexin 500mg qid with unresolved symptoms • Cephalexin was extended for 5 days, and Nellie was ordered a breast ultrasound • She returned again once antibiotics were complete, with continued unresolved symptoms. Ultrasound was clear. • Collaborating physician was consulted, and recommended a course of Trimethoprim/ Sulfamethoxazole 160/800mg bid x 10 days.
  • 20. Referral10 - General Surgery: • if ultrasound shows breast abscess; • for needle aspirate, or incision and drainage of abscess.
  • 21. Nellie Turner 31 years old (pseudonym) The Therapeutic I Community Health Centre 123 University Avenue, Anytown, ON. N0N 0N0 Phone 416-321-0987 _________________________________________________ Name: Nellie Turner (DOB: January 1, 1981, NKDA) Address: 1000 Fantasy Lane, Anytown, ON. L0R1B0 Date: November 22, 2012 Trimethoprim/ sulfamethoxazole 160 mg/800 mg bid x 10 days. Take one tablet by mouth, twice daily until finished. M: 20 tabs R: 0 repeats Nancy Nurse RN (EC), 54321 (signed) Nancy Nurse, RN (EC), 54321 (printed)
  • 22. Nellie Turner Monitoring and Follow up 31 years old (pseudonym) • Important to monitor baby Jonah to signs of dehydration, or secondary infection (e.g. thrush) • Client returned after the 10-day course of, reporting that symptoms have nearly entirely resolved, her energy level had returned, and the erythema and had engorgement had disappeared. • The painful, firm thickening has nearly completely resolved. Acceptability • Client was satisfied with resolution, happy to return to normal functioning, and glad that Baby Jonah continued to do well.
  • 23.
  • 24. 1. WorldHealthOrganization. (2000). Mastitis: Causes and management. Geneva:WHO. Retrieved from: http://www.who.int/maternal_child_adolescent/documents/fch_cah_00_13/en/ 2. Foxman, B., D'Arcy, H., Gillespie, B., Bobo, J. K., & Schwartz, K. (2002). Lactation Mastitis: Occurrence and Medical Management among 946 Breastfeeding Women in the United States. American Journal of Epidemiology 155(2) pp. 103-114. 3. Jahanfar S, Ng CJ, Teng CL. (2009). Antibiotics for mastitis in breastfeeding women. Cochrane Database of Systematic Reviews 1. 4. Amir, L.H., Forster, D., McLachlan, H., & Lumley J. (2004). Incidence of breast abscess in lactating women: report from an Australian cohort. BJOG: an International Journal of Obstetrics and Gynaecology 111. pp. 1378–1381 5. Spencer, J. (2008). Management of mastitis in breastfeeding women. American family physician. 78 (6). PP.727-732. 6. The Royal Womens’ Hospital. (2012). Mastitis: lactational (algorithm). Parkville, VIC. Australia. Retrieved from: http://www.thewomens.org.au/MastitisLactationalAlgorithm. 7. Lawrence R.A., & Lawrence, R.M. (2011). Breastfeeding: A Guide for the Medical Professions. 7th ed,. Maryland Heights, MO: Elsevier Mosby. 8. Academy of Breastfeeding Medicine Protocol Committee (ABMPC). Berens, P. (ed). (2009) ABM clinical protocol #20: engorgement. Breastfeed Med 4(2):pp. 111-3. Retrieved from: http://www.guideline.gov/content.aspx?id=15183&search=Pumps%2C+Breast +
  • 25. 9. National Library of Medicine. Toxicology Data Network (TOXNET). *2011) Trimethoprim-sulfamethoxazole. Drug and Lactation Database (LACTMED). Retrieved from: http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~vP0pfa:1. 10. Clavulin. [CPhA Drug Monograph]. Retrieved from e-Therapeutics+: e-CPS: https://www.e-therapeutics.ca/cps.showMonograph.action 11. Sulfamethoxazole-Trimethoprim [CPhA Drug Monograph]. Retrieved from e- Therapeutics+: e-CPS: https://www.e- therapeutics.ca/cps.select.preliminaryFilter.action?simplePreliminaryFilter=sulfamet hoxazole# 12. Cephalexin. [CPhA Drug Monograph]. Retrieved from e-Therapeutics+: e-CPS: https://www.e- therapeutics.ca/cps.select.preliminaryFilter.action?simplePreliminaryFilter= cephalex in 13. Ciprofloxacin. [CPhA Drug Monograph]. Retrieved from e-Therapeutics+: e-CPS: https://www.e- therapeutics.ca/cps.select.preliminaryFilter.action?simplePreliminaryFilter= ciproflox acin 14. Cloxacillin.. [CPhA Drug Monograph]. Retrieved from e-Therapeutics+: e-CPS: https://www.e- therapeutics.ca/cps.showMonograph.action?simpleQuery=Cloxacillin% 20 15. College of Nurses of Ontario. (2011). Practice Standards: Nurse Practitioner Revised 2011. Toronto, ON: Author.
  • 26. 16. Newman Breastfeeding Centre. (2009). Blocked ducts and mastitis. Retrieved from: http://www.nbci.ca/index.php?option=com_content&view=article&id=7:blocked- ducts-a-mastitis&catid=5:information&Itemid=17 17. Mangesi L, Dowswell T. (2010). Treatments for breast engorgement during lactation (Review) The Cochrane Library. 9

Notas do Editor

  1. Localized unilateral