This PowerPoint helps students to consider the concept of infinity.
Activation of Brain Endothelium by Soluble Amyloid Protien Aggregates, Melissa Moss, PhD
1. F.J. Gonzalez-Velasquez, J.W. Reed, J.W. Fuseler, E.E. Matherly, D.D. Soto-Ortega, J.A. Kotarek, and M.A. Moss Department of Chemical Engineering University of South Carolina Activation of Brain Endothelium by Soluble Amyloid Protein Aggregates
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15. Mimic cell-surface growth Correlate growth with physiological activity Publications: Kotarek and Moss (2008) Anal. Biochem. 378: 15-24. Kotarek and Moss (2009) In Preparation. Employ novel techniques to quantify A aggregation POPC POPC/DPPC monomer aggregate biotin tag Au electrode surface unlabeled soluble aggregate avidin biotinylated Ab 1-40 monomer unlabeled A 1-40 monomer supported phospholipid bilayer (SPB) A 1-40 aggregation intermediate
16. Define inhibitor structure-function relationships Utilize inhibitors to understand, control protein aggregation Elongation Association Identify, characterize inhibitors that target specific growth mechanisms Publications: Reyes Barcelo et al (2009) J Biol Eng 3:5. Davis et al (2009) Mol Pharmacol, 76: 405-413.
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18. F.J. Gonzalez-Velasquez, J.W. Reed, J.W. Fuseler, E.E. Matherly, D.D. Soto-Ortega, J.A. Kotarek, and M.A. Moss Department of Chemical Engineering University of South Carolina Activation of Brain Endothelium by Soluble Amyloid Protein Aggregates
![Alzheimer’s Pathology ,[object Object],[object Object],Alzheimer’s Brain Pathology A Fibrils Nichols et al. (2002) Biochemistry , 41: 6115-27. Courtesy of D. Dickson, Mayo Clinic, Jacksonville. Cerebral Amyloid Angiopathy http://www.adrc.wustl.edu/adrc2.html Amyloid Plaques](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)