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BIFURCATION STENTING
Coronary artery disease
Subha RathaYatra 2014
GUESS SOMETHING PEEINGTHROUGH STENTWINDOW?
BASIS
 The approach to bifurcation lesions is based on the angiographic configuration of
the lesion(s) in the main branch and the side branch
 Significant disease (>50% stenosis) in the ostium of the side branch increases the
likelihood of side-branch closure as well as the restenosis rate after PCI
ONE STENTVSTWO STENT STRATEGY
 Default approach is one-stent technique ± provisional angioplasty/stent to side
branch
 Use two-stent technique if side branch is significant and has high-risk features for
closure
RISK
 The risk of side-branch closure with an ostial narrowing approaches 15%
 PCI across an uninvolved side branch carries a less than 1% risk of occlusion
CLASSIFICATION
MEDINA CLASSIFICATION
GUIDE CATHETER
 7 F or 8 F guiding catheter should be selected if the operator anticipates using
two stents
 A 6 F guiding catheter can accommodate only two monorail balloon
 8 F guiding catheter can accommodate two stent systems as well as other large-
diameter PCI devices such as the Rotablator or the Flextome Cutting Balloon
 The maximum Rotablator burr that can be used with a 6 F guiding catheter is 1.5
mm
 It may be prudent to “upsize” guiding catheters when approaching any
bifurcation lesion so that all options remain available if trouble occurs during the
procedure
GUIDEWIRE
 To protect the side branch, two guidewires are placed, one in the side branch and
one in the main vessel
 The order of inflation is relatively unimportant
 Wire markers or using two different wire types is helpful to reduce confusion
during balloon inflations and wire repositioning
 When using a two-guidewire system, the guidewires may become entangled after
multiple wire manipulations
 . Efforts should be made to avoid guidewire entanglement, which will prevent
advancement of the balloon and may result in failure to recross the stenosis.
BALLOON
 Standard balloon use
 Different balloon sizes may be required for each branch
 Sequential balloon inflations or simultaneous “kissing” balloon inflations can be
performed with elimination of plaque shifting being the advantage of the latter
 It is important to make sure that the main vessel can accommodate both balloon
diameters when performing kissing balloon inflations (proximal vessel should be
at least two thirds of the combined balloon diameters)
 After stent placement in the main branch and the side branch, simultaneous
kissing balloon inflations are critical to restore the circular and fully expanded
stent to each lumen
 Failure to perform final kissing balloon inflation will likely lead to restenosis
SEQUENTIAL BRANCH INFLATIONS
 Dilate the main vessel first, the side branch second, and finish dilation in the main
branch
 A sequential main-side-main branch inflation strategy provides a safe and
straightforward approach
 Sequential inflations may result in suboptimal main vessel dilation and plaque
shifting , requiring repeated dilatations
 An unprotected major vessel dissection will require reinstrumentation and
jeopardize further attempts to open the side branch
 Serial inflations, first in one branch then in the other, as opposed to simultaneous
balloon inflations in both branches, may limit the need for extra manoeuvres.
T STENTING-2 STENTS
 The side branch off ostium ,therefore
no crush
IAKOVOU I., GE L.,AND COLOMBOA.: CONTEMPORARY STENTTREATMENTOF
CORONARY BIFURCATIONS. J AM COLLCARDIOL 2005; 46: PP. 1446-1455
 AlthoughT stenting is less laborious than both culotte and crush, theT-technique
invariably leads to inadequate coverage of the SB ostium and has consequently
been discontinued in a number of institutions except for either isolated SB ostial
lesions or when the result of a provisional single-stent strategy is suboptimal
V STENT-2 STENTS
Y STENTS-3 STENTS
DOUBLE BARREL(V STENTVARIANT)
CULLOTTE TECHNIQUE
 Angle <70 degree
 Bend branch stenting first
CHEVALIER B., GLATT B., ROYERT., AND GUYON P.: PLACEMENT OF
CORONARY STENTS IN BIFURCATION LESIONS BYTHE “CULOTTE”
TECHNIQUE. AM J CARDIOL 1998; 82: PP. 943-949
 First described by Chevalier et al. using BMS, the culotte technique results in two
layers of stent proximal to the bifurcation, full coverage of the SB ostium and of
both branches distal to the bifurcation.The technique is suitable for all angles of
bifurcation, but it does leave a double stent layer at both the carina and the
proximal part of the bifurcation. Furthermore, rewiring both branches through
stent struts may prove both difficult and time consuming.
CRUSHTECH
 Side branch stenting protrudes into
and get crushed after main stent
expansion
COLOMBOA., STANKOVIC G., ORLIC D.,CORVAJA N., LIISTRO F., AIROLDI F., CHIEFFO A.,
SPANOSV., MONTORFANO M.,AND DI MARIO C.: MODIFIEDT-STENTINGTECHNIQUE
WITH CRUSHING FOR BIFURCATION LESIONS: IMMEDIATE RESULTSAND 30-DAY
OUTCOME.CATHETER CARDIOVASC INTERV 2003; 60: PP. 145-151
 CRUSH was first introduced by Colombo et al. as a modifiedT-stenting technique
using DES, ensures uninterrupted patency of both the MB and the SB as well as
excellent coverage of the ostium of the SB. Final kissing balloon (FKB) dilatation is
now considered mandatory to allow optimal strut contact and drug delivery to the
ostium of the SB 15 16 .
MINICRUSH
 The minicrush technique differs from classical crush in the amount of the SB stent
protruding into the MB, with protrusion into the proximal end of the SB ostium in
the latter, limiting multiple layering of stent struts and allowing for more
complete stent endothelialization
REVERSE CRUSH
 The reverse crush technique is employed when a provisional single-stent strategy
becomes suboptimal. Following the placement of a stent in the SB, an
appropriately sized balloon is positioned in the MB at the level of the bifurcation,
before retracting the SB stent 2–3 mm into the MB and deploying it. If the result in
the SB is satisfactory, the deploying balloon and SB wire are removed and the MB
balloon is inflated, thus crushing the SB stent. Subsequent steps are similar to
those of conventional crush technique.
1VS 2 STENT STRATEGY IN DES ERA
ONLY FOR EXPERTS
 Crush
 Culottes
 Angle is < 70 degree
 Excellent coverage in excellent hand
CRUSH
 Wire both vessels
 Predilate both
 Two stents are then advanced and positioned into each vessel of the bifurcation
with the proximal end of the side-branch stent in the main vessel
 The side-branch stent is deployed first
 The main-branch stent is then deployed
 The side branch then needs to be rewired and balloon dilated
 Final kissing balloon inflation is then performed to complete the procedure
IAKOVOU I., GE L.,AND COLOMBOA.: CONTEMPORARY STENTTREATMENTOF
CORONARY BIFURCATIONS. J AM COLLCARDIOL 2005; 46: PP. 1446-1455
 The simultaneous kissing stent (SKS) technique is considered most suitable for
proximal bifurcation lesions, such as a distal left–main bifurcation lesion with an
angle of <90° between the two branches .The technique has the advantage that
control of the MB and the SB are not lost at any stage during the procedure and
FKB dilatation can be undertaken without the need to recross either stent.
JAIL FOR ONLY UNPARDONABLE MISTAKE
 Physiologic Guidance for Bifurcation or Jailed Side-Branch Stenting is decided
by IVUS and FFR
IVUS
 To overcome visual elusion of best result
FFR
 By using FFR, the “jailed” side branches with an FFR >0.75 have a very low clinical
event rate without further balloon or stent therapy to the side branch
 Performing FFR of ostial side-branch lesions that appear to be <70% from
angiography can prove that most of these lesions are not physiologically
significant
KEEP IT SIMPLE STUPID: KISS
 Wire both main branch and side branch if side-branch loss is important.
 Consider treating side branch first (i.e., balloon dilatation, rotational atherectomy, or cutting balloon).
 Dilate and stent main branch; reassess side branch (can use FFR to determine hemodynamic significance).
 Provisional PTCA + stent side branch. If stenting side branch, stent with pullback technique.
 Choice of two-stent technique depends on size of proximal vessel, an assessment of the importance and risk of side-
branch closure, and operator expertise and preference.
 Use two wires if side branch loss is important.
 Dilate smaller branch first or use Rotablator or cutting balloon.
 Dilate and stent main branch; reassess side branch.
 Redilate side branch.
 Stent side branch through main stent only when absolutely necessary; use FFR to assess physiologic significance of side
branch.
 If a two-stent technique is used, final kissing balloon inflation is necessary to optimize outcomes
SUBHA RATHAYATRA -2014

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Bifurcation stenting

  • 1. BIFURCATION STENTING Coronary artery disease Subha RathaYatra 2014
  • 3. BASIS  The approach to bifurcation lesions is based on the angiographic configuration of the lesion(s) in the main branch and the side branch  Significant disease (>50% stenosis) in the ostium of the side branch increases the likelihood of side-branch closure as well as the restenosis rate after PCI
  • 4. ONE STENTVSTWO STENT STRATEGY  Default approach is one-stent technique ± provisional angioplasty/stent to side branch  Use two-stent technique if side branch is significant and has high-risk features for closure
  • 5. RISK  The risk of side-branch closure with an ostial narrowing approaches 15%  PCI across an uninvolved side branch carries a less than 1% risk of occlusion
  • 8. GUIDE CATHETER  7 F or 8 F guiding catheter should be selected if the operator anticipates using two stents  A 6 F guiding catheter can accommodate only two monorail balloon  8 F guiding catheter can accommodate two stent systems as well as other large- diameter PCI devices such as the Rotablator or the Flextome Cutting Balloon  The maximum Rotablator burr that can be used with a 6 F guiding catheter is 1.5 mm  It may be prudent to “upsize” guiding catheters when approaching any bifurcation lesion so that all options remain available if trouble occurs during the procedure
  • 9. GUIDEWIRE  To protect the side branch, two guidewires are placed, one in the side branch and one in the main vessel  The order of inflation is relatively unimportant  Wire markers or using two different wire types is helpful to reduce confusion during balloon inflations and wire repositioning  When using a two-guidewire system, the guidewires may become entangled after multiple wire manipulations  . Efforts should be made to avoid guidewire entanglement, which will prevent advancement of the balloon and may result in failure to recross the stenosis.
  • 10. BALLOON  Standard balloon use  Different balloon sizes may be required for each branch  Sequential balloon inflations or simultaneous “kissing” balloon inflations can be performed with elimination of plaque shifting being the advantage of the latter  It is important to make sure that the main vessel can accommodate both balloon diameters when performing kissing balloon inflations (proximal vessel should be at least two thirds of the combined balloon diameters)  After stent placement in the main branch and the side branch, simultaneous kissing balloon inflations are critical to restore the circular and fully expanded stent to each lumen  Failure to perform final kissing balloon inflation will likely lead to restenosis
  • 11. SEQUENTIAL BRANCH INFLATIONS  Dilate the main vessel first, the side branch second, and finish dilation in the main branch  A sequential main-side-main branch inflation strategy provides a safe and straightforward approach  Sequential inflations may result in suboptimal main vessel dilation and plaque shifting , requiring repeated dilatations  An unprotected major vessel dissection will require reinstrumentation and jeopardize further attempts to open the side branch  Serial inflations, first in one branch then in the other, as opposed to simultaneous balloon inflations in both branches, may limit the need for extra manoeuvres.
  • 12. T STENTING-2 STENTS  The side branch off ostium ,therefore no crush
  • 13. IAKOVOU I., GE L.,AND COLOMBOA.: CONTEMPORARY STENTTREATMENTOF CORONARY BIFURCATIONS. J AM COLLCARDIOL 2005; 46: PP. 1446-1455  AlthoughT stenting is less laborious than both culotte and crush, theT-technique invariably leads to inadequate coverage of the SB ostium and has consequently been discontinued in a number of institutions except for either isolated SB ostial lesions or when the result of a provisional single-stent strategy is suboptimal
  • 17. CULLOTTE TECHNIQUE  Angle <70 degree  Bend branch stenting first
  • 18. CHEVALIER B., GLATT B., ROYERT., AND GUYON P.: PLACEMENT OF CORONARY STENTS IN BIFURCATION LESIONS BYTHE “CULOTTE” TECHNIQUE. AM J CARDIOL 1998; 82: PP. 943-949  First described by Chevalier et al. using BMS, the culotte technique results in two layers of stent proximal to the bifurcation, full coverage of the SB ostium and of both branches distal to the bifurcation.The technique is suitable for all angles of bifurcation, but it does leave a double stent layer at both the carina and the proximal part of the bifurcation. Furthermore, rewiring both branches through stent struts may prove both difficult and time consuming.
  • 19. CRUSHTECH  Side branch stenting protrudes into and get crushed after main stent expansion
  • 20. COLOMBOA., STANKOVIC G., ORLIC D.,CORVAJA N., LIISTRO F., AIROLDI F., CHIEFFO A., SPANOSV., MONTORFANO M.,AND DI MARIO C.: MODIFIEDT-STENTINGTECHNIQUE WITH CRUSHING FOR BIFURCATION LESIONS: IMMEDIATE RESULTSAND 30-DAY OUTCOME.CATHETER CARDIOVASC INTERV 2003; 60: PP. 145-151  CRUSH was first introduced by Colombo et al. as a modifiedT-stenting technique using DES, ensures uninterrupted patency of both the MB and the SB as well as excellent coverage of the ostium of the SB. Final kissing balloon (FKB) dilatation is now considered mandatory to allow optimal strut contact and drug delivery to the ostium of the SB 15 16 .
  • 21. MINICRUSH  The minicrush technique differs from classical crush in the amount of the SB stent protruding into the MB, with protrusion into the proximal end of the SB ostium in the latter, limiting multiple layering of stent struts and allowing for more complete stent endothelialization
  • 22. REVERSE CRUSH  The reverse crush technique is employed when a provisional single-stent strategy becomes suboptimal. Following the placement of a stent in the SB, an appropriately sized balloon is positioned in the MB at the level of the bifurcation, before retracting the SB stent 2–3 mm into the MB and deploying it. If the result in the SB is satisfactory, the deploying balloon and SB wire are removed and the MB balloon is inflated, thus crushing the SB stent. Subsequent steps are similar to those of conventional crush technique.
  • 23. 1VS 2 STENT STRATEGY IN DES ERA
  • 24. ONLY FOR EXPERTS  Crush  Culottes  Angle is < 70 degree  Excellent coverage in excellent hand
  • 25. CRUSH  Wire both vessels  Predilate both  Two stents are then advanced and positioned into each vessel of the bifurcation with the proximal end of the side-branch stent in the main vessel  The side-branch stent is deployed first  The main-branch stent is then deployed  The side branch then needs to be rewired and balloon dilated  Final kissing balloon inflation is then performed to complete the procedure
  • 26. IAKOVOU I., GE L.,AND COLOMBOA.: CONTEMPORARY STENTTREATMENTOF CORONARY BIFURCATIONS. J AM COLLCARDIOL 2005; 46: PP. 1446-1455  The simultaneous kissing stent (SKS) technique is considered most suitable for proximal bifurcation lesions, such as a distal left–main bifurcation lesion with an angle of <90° between the two branches .The technique has the advantage that control of the MB and the SB are not lost at any stage during the procedure and FKB dilatation can be undertaken without the need to recross either stent.
  • 27.
  • 28. JAIL FOR ONLY UNPARDONABLE MISTAKE  Physiologic Guidance for Bifurcation or Jailed Side-Branch Stenting is decided by IVUS and FFR
  • 29. IVUS  To overcome visual elusion of best result
  • 30. FFR  By using FFR, the “jailed” side branches with an FFR >0.75 have a very low clinical event rate without further balloon or stent therapy to the side branch  Performing FFR of ostial side-branch lesions that appear to be <70% from angiography can prove that most of these lesions are not physiologically significant
  • 31. KEEP IT SIMPLE STUPID: KISS  Wire both main branch and side branch if side-branch loss is important.  Consider treating side branch first (i.e., balloon dilatation, rotational atherectomy, or cutting balloon).  Dilate and stent main branch; reassess side branch (can use FFR to determine hemodynamic significance).  Provisional PTCA + stent side branch. If stenting side branch, stent with pullback technique.  Choice of two-stent technique depends on size of proximal vessel, an assessment of the importance and risk of side- branch closure, and operator expertise and preference.  Use two wires if side branch loss is important.  Dilate smaller branch first or use Rotablator or cutting balloon.  Dilate and stent main branch; reassess side branch.  Redilate side branch.  Stent side branch through main stent only when absolutely necessary; use FFR to assess physiologic significance of side branch.  If a two-stent technique is used, final kissing balloon inflation is necessary to optimize outcomes