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Central Nervous System www.freelivedoctor.com
Neural Tissue Anatomical subdivisions of NS Made up of neurons  and neuroglia cells www.freelivedoctor.com
Functional Overview of NS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Peripheral Nervous System www.freelivedoctor.com
Cellular Organization of Neural Tissue  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
General Neuron Structure ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Astrocytes :  largest & most numerous ,[object Object],[object Object],[object Object],www.freelivedoctor.com
Oligodendrocyte ,[object Object],[object Object],[object Object],www.freelivedoctor.com
Microglia cells ,[object Object],[object Object],[object Object],www.freelivedoctor.com
Ependymal cells ,[object Object],[object Object],[object Object],www.freelivedoctor.com
Schwann Cells  and Peripheral Axons ,[object Object],[object Object],myelinated www.freelivedoctor.com
Structural   Neuron Classification ,[object Object],[object Object],[object Object],[object Object],[object Object],Axon hillock See fig. 13-10 www.freelivedoctor.com
Structural Neuron Classification cont. . .   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Functional Neuron Classification ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Synapse ,[object Object],[object Object],[object Object],www.freelivedoctor.com
Chemical Synapse   vs.   Electrical Synapse ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Chem. Synapse Structure ,[object Object],[object Object],[object Object],www.freelivedoctor.com
Neuron Organization ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Anatomical Organizatin of NS ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Brain and Cranial Nerves ,[object Object],[object Object],[object Object],[object Object]
Major Brain Subdivisions  ,[object Object],[object Object],[object Object],[object Object],[object Object],Brainstem
Gray & White Matter Organization ,[object Object],[object Object]
Cranial Meninges ,[object Object],[object Object],[object Object],[object Object],2.  Arachnoid  - spidery, holds blood vessels 3.  Pia mater  - "delicate mother"
Arachnoid granulations:  This is where the CSF produced in the choroid plexuses of the ventricles and which has circulated into the subarachnoid space is reabsorbed.  Longitudinal fissure
Four Ventricles ,[object Object],[object Object],Lined by ependymal cells
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CSF: Cerebro-Spinal Fluid Fig 15.6
Blood Brain Barrier (BBB) ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],Cerebrum
Cerebral Hemispheres . . . ,[object Object],[object Object],[object Object]
Cerebral Cortex and Central White Matter ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Basal (or cerebral) Nuclei Misnomer: basal ganglia Gray matter internal to the cerebral cortex, below floor of lateral ventricles. Function:  modulate motor output from the cerebral cortex.  Subconscious control of skeletal muscle tone and coordination of learned movement patterns. Parkinson's disease is caused by the loss of at least 80% of the dopaminergic neurons in basal nuclei and substantia nigra (resting tremor) Fig 15.11
Diencephalon Epithalamus Pineal gland - produces melatonin,    sets diurnal cycles Thalamus  (~12 nuclei) Hypothalamus Just superior to optic chiasma Infundibulum - connects to pituitary gland Some functions: Control of autonomic nervous system  Coordination of nervous and endocrine systems  Secretion of hormones - ADH and oxytocin
Mesencephalon) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Metencephalon:  Cerebellum Hemispheres and lobes  Cortex -gray surface  with folia - fine ridges and  sulci - grooves between the ridges Purkinje cells , axons of which become arbor vitae (white matter) in center Regulation of posture and balance
Metencephalon: Pons Myelencephalon: Medulla oblongata ,[object Object],[object Object],[object Object],[object Object]
Cranial Nerves ,[object Object],[object Object],[object Object],[object Object],[object Object]
Olfactory Nerve (= CN or N I) ,[object Object],[object Object],[object Object],[object Object]
Optic Nerve (N II) ,[object Object],[object Object],[object Object]
Oculomotor (N III) ,[object Object],[object Object],[object Object],[object Object]
Trochlear (N IV) ,[object Object],[object Object],[object Object],[object Object]
Trigeminal (N V) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Abducens (CN VI) C: Motor  O: Pons D: Runs lateral rectus eye muscle
Facial (N VII) ,[object Object],[object Object],[object Object]
Vestibulocochlear (N VIII)
Glossopharyngeal (CN IX) C: mixed O: sensory from posterior 1/3 of tongue / motor from medulla oblongata D: medulla / muscles for swallowing, parotid gland
Vagus (N X) ,[object Object],[object Object],[object Object]
Accessory (N XI) and  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Spinal Cord and Spinal Nerves Explain spinal cord anatomy, including gray and white matter and meninges  (give the general functions of this organ). Discuss the structure and functions of the spinal nerves and plexuses. Describe the structural components of reflexes.
[object Object],[object Object],[object Object],[object Object],Adult spinal cord:
1. Cervical Enlargement Gray matter expanded to incorporate more sensory input from limbs and  more cell bodies for motor control of limbs
Spinal Meninges 3) Pia mater 2) Arachnoid 1) Dura mater Three membranes surround all of CNS 1)  Dura mater  - "tough mother", strong 2)  Arachnoid  meninx  - spidery looking, carries blood vessels, etc. Subarachnoid space 3)  Pia mater  - "delicate mother", adheres  tightly to surface of spinal cord
Inferior End of Spinal Cord ,[object Object],[object Object],[object Object]
Lumbar Puncture (= Spinal Tap) For clinical examination of CSF or administration of radiopaque  dyes, drugs and sometimes anesthetics  However: mostly “epidurals” for anesthetics  L3 L4
Organization of Cord Cross Section  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Peripheral Nerves Definition: bundles of axons.  AKA tracts in CNS   Organization – coverings: Epineurium     wraps entire nerve  Perineurium     wraps fascicles of tracts Endoneurium     wraps individual axons
Anatomy of a Peripheral nerve  Function: sensory - afferent motor - efferent mixed - contains axons of both
Organization of Spinal Nerves: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],1.  Fig 14-7
Dermatomes ,[object Object],[object Object]
4 Principal   Plexuses Braids of ventral rami of cervical,  thoracic, lumbar or sacral  spinal  nerves Cervical Plexus Phrenic nerve - innervates diaphragm
Brachial Plexus Musculocutaneous nerve - innervates  biceps and brachialis muscles Median nerve - innervates lateral flexors Ulnar nerve - innervates medial flexors Radial nerve - innervates forearm extensors
Reflexes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Autonomic Division of NS   Compare and contrast the structures of the sympathetic and the parasympathetic divisions, including functions and neurotransmitters. Show the levels of integration in the ANS, and compare these with the SNS. www.freelivedoctor.com
Overview of ANS ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
[object Object],[object Object],[object Object],? www.freelivedoctor.com neuron #1 preganglionic  presynaptic  neuron #2 Ganglionic postsynaptic effector Preganglionic fiber (=axon): Always myelinated Postganglionic fiber: Always unmyelinated
Sympathetic Division ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Special Case:   Adrenal medulla   ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Sympathetic Neuroeffector Junctions Differ from somatic neuromuscular junctions Varicosities www.freelivedoctor.com
Summary of Sympathetic Division ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Para – Sympathetic Division Craniosacral  division Preganglionic neurons (cell bodies)  located in brain stem & sacral segments of spinal cord Ganglionic neurons (cell bodies) in ganglia near target organs:  Intramural ganglia Effects of parasympathetic division ? www.freelivedoctor.com
Summary of Parasympathetic Division ,[object Object],[object Object],www.freelivedoctor.com
Anatomy of Dual Innervation ,[object Object],[object Object],[object Object],www.freelivedoctor.com
www.freelivedoctor.com
www.freelivedoctor.com

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Reproductive System

  • 1. Central Nervous System www.freelivedoctor.com
  • 2. Neural Tissue Anatomical subdivisions of NS Made up of neurons and neuroglia cells www.freelivedoctor.com
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  • 4. Peripheral Nervous System www.freelivedoctor.com
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  • 24. Arachnoid granulations: This is where the CSF produced in the choroid plexuses of the ventricles and which has circulated into the subarachnoid space is reabsorbed. Longitudinal fissure
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  • 31. Basal (or cerebral) Nuclei Misnomer: basal ganglia Gray matter internal to the cerebral cortex, below floor of lateral ventricles. Function: modulate motor output from the cerebral cortex. Subconscious control of skeletal muscle tone and coordination of learned movement patterns. Parkinson's disease is caused by the loss of at least 80% of the dopaminergic neurons in basal nuclei and substantia nigra (resting tremor) Fig 15.11
  • 32. Diencephalon Epithalamus Pineal gland - produces melatonin, sets diurnal cycles Thalamus (~12 nuclei) Hypothalamus Just superior to optic chiasma Infundibulum - connects to pituitary gland Some functions: Control of autonomic nervous system Coordination of nervous and endocrine systems Secretion of hormones - ADH and oxytocin
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  • 34. Metencephalon: Cerebellum Hemispheres and lobes Cortex -gray surface with folia - fine ridges and sulci - grooves between the ridges Purkinje cells , axons of which become arbor vitae (white matter) in center Regulation of posture and balance
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  • 42. Abducens (CN VI) C: Motor O: Pons D: Runs lateral rectus eye muscle
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  • 45. Glossopharyngeal (CN IX) C: mixed O: sensory from posterior 1/3 of tongue / motor from medulla oblongata D: medulla / muscles for swallowing, parotid gland
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  • 48. Spinal Cord and Spinal Nerves Explain spinal cord anatomy, including gray and white matter and meninges (give the general functions of this organ). Discuss the structure and functions of the spinal nerves and plexuses. Describe the structural components of reflexes.
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  • 50. 1. Cervical Enlargement Gray matter expanded to incorporate more sensory input from limbs and more cell bodies for motor control of limbs
  • 51. Spinal Meninges 3) Pia mater 2) Arachnoid 1) Dura mater Three membranes surround all of CNS 1) Dura mater - "tough mother", strong 2) Arachnoid meninx - spidery looking, carries blood vessels, etc. Subarachnoid space 3) Pia mater - "delicate mother", adheres tightly to surface of spinal cord
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  • 53. Lumbar Puncture (= Spinal Tap) For clinical examination of CSF or administration of radiopaque dyes, drugs and sometimes anesthetics However: mostly “epidurals” for anesthetics L3 L4
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  • 55. Peripheral Nerves Definition: bundles of axons. AKA tracts in CNS Organization – coverings: Epineurium wraps entire nerve Perineurium wraps fascicles of tracts Endoneurium wraps individual axons
  • 56. Anatomy of a Peripheral nerve Function: sensory - afferent motor - efferent mixed - contains axons of both
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  • 59. 4 Principal Plexuses Braids of ventral rami of cervical, thoracic, lumbar or sacral spinal nerves Cervical Plexus Phrenic nerve - innervates diaphragm
  • 60. Brachial Plexus Musculocutaneous nerve - innervates biceps and brachialis muscles Median nerve - innervates lateral flexors Ulnar nerve - innervates medial flexors Radial nerve - innervates forearm extensors
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  • 62. Autonomic Division of NS Compare and contrast the structures of the sympathetic and the parasympathetic divisions, including functions and neurotransmitters. Show the levels of integration in the ANS, and compare these with the SNS. www.freelivedoctor.com
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  • 67. Sympathetic Neuroeffector Junctions Differ from somatic neuromuscular junctions Varicosities www.freelivedoctor.com
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  • 69. Para – Sympathetic Division Craniosacral division Preganglionic neurons (cell bodies) located in brain stem & sacral segments of spinal cord Ganglionic neurons (cell bodies) in ganglia near target organs: Intramural ganglia Effects of parasympathetic division ? www.freelivedoctor.com
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Notas do Editor

  1. Buoyancy : brain weight in air: about 1.4 kg – in CSF about 50 g (= 97% lighter) because it is only a little denser than the CSF. Protects brain from crushing itself. Arachnoid granulations only appear at about 3 years of age. Infants are therefore especially sensitive to alterations or hyperactivity of the choroid plexuses.l
  2. Alcohol, nicotine and anesthetics can diffuse through BBB. Blood borne toxins (urea, food toxins, bacterial toxins) cannot get through. Recent discovery: During prolonged emotional stress the tight junctions of the BBB are opened.
  3. In 90-95% of people left side has more control over language, math and logic. Right side is more involved withy visual-spatial skills, intuition, emotion, artistic and musical skill.
  4. Substantia nigra is in mesencephalon
  5. Thalamus = 80% of diencephalon. Gateway (relay station) to the cerebral cortex not just for sensory input but for all info. Processing and editing also takes place. About 12 nuclei Hypothalamus also about 12 nuclei. Main visceral control center of the body
  6. Scm = sternocleido mastoid muscle
  7. 31 pairs of spinal nerves – designated as are vertebrae a. 8 cervical b. 12 thoracic c. 5 lumbar d. 5 sacral
  8. Plexus - plexuses
  9. do NOT require cerebral processing but can be modified by cerebral control
  10. General functions 1. excitatory of digestive organs 2. depresses heart rate and blood pressure 3. constricts pupils of eyes 4. sexual arousal 5. slows breathing 6. constricts urinary bladder