Classification Of Virus[Summary]

Basic virus structure Capsid protein Nucleocapsid Naked capsid virus = + Nucleocapsid Lipid membrane, glycoproteins Enveloped virus + www.freelivedoctor.com DNA RNA or

Properties of enveloped viruses ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Adapted from Murray, P.R. Rosenthal K.S., Pfaller, M.A. (2005) Medical Microbiology, 5 th edition, Elsevier Mosby, Philadelphia, PA Box 6-5 www.freelivedoctor.com

Properties of naked capsid viruses ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Adapted from Murray, P.R. Rosenthal K.S., Pfaller, M.A. (2005) Medical Microbiology, 5 th edition, Elsevier Mosby, Philadelphia, PA , Box 6-4 www.freelivedoctor.com

Classification of Human Viruses www.freelivedoctor.com

Variations on the replication theme www.freelivedoctor.com

Summary: structure, classification & replication ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Summary: laboratory virology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Cycle of infection Secondary sites Spread Entry Shedding Shedding Local Lymphatic Neuronal Blood (viremia) Primary site www.freelivedoctor.com

Time course of infection; host response infection without spread: infection with spread: host response: www.freelivedoctor.com 0 2 4 6 8 10 12 time (days)

Patterns of disease www.freelivedoctor.com

Summary: Pathogenesis & Genetics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

For each virus, know: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Human papillomavirus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Parvovirus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Polyomavirus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Adenovirus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Influenza ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Paramyxoviruses ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rabies www.freelivedoctor.com

Rotavirus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Summary www.freelivedoctor.com

Paramyxoviruses ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Rabies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Time course of Rabies infections www.freelivedoctor.com

Rotavirus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Enteroviruses ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Arboviruses ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Arboviruses: Vectors, Hosts, and Diseases www.freelivedoctor.com

Rubella virus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

RNA Hepatitis Viruses ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

HGV Flavi ///////////hepe www.freelivedoctor.com

Hepatitis B Virus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Hepatitis B virus www.freelivedoctor.com

Immunological events of acute vs. chronic HBV infection From Murray et. al., Medical Microbiology 5 th edition, 2005, Chapter 66, published by Mosby Philadelphia,, A) Acute B) Chronic www.freelivedoctor.com

Clinical interpretation of the Hepatitis B antigen panel www.freelivedoctor.com

Hepatitis D Virus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

HIV ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

HIV-1 Replication Cycle CCR5 CD4 CXCR4 Reverse Transcriptase Integrase Protease Beth D. Jamieson, Ph.D. www.freelivedoctor.com Reverse Transcription Integration Uncoating Assembly Budding Attachment Maturation

Natural Course of HIV-1 Infection www.freelivedoctor.com

Herpesviruses Herpes simplex I & II (cold sores, genital herpes) Varicella zoster (chicken pox, shingles) Cytomegalovirus (microcephaly, infectious mono) Epstein-Barr virus (mononucleosis, Burkitt’s lymphoma) Human herpesvirus 6 & 7 (Roseola) Human herpesvirus 8 (Kaposi’s sarcoma) www.freelivedoctor.com

Virus Subfamily Disease Site of Latency Herpes Simplex Virus I  Orofacial lesions Sensory Nerve Ganglia Herpes Simplex Virus II  Genital lesions Sensory Nerve Ganglia Varicella Zoster Virus  Chicken Pox Sensory Nerve Ganglia Recurs as Shingles Cytomegalovirus  Microcephaly/Mono Lymphocytes Human Herpesvirus 6  Roseola Infantum CD4 T cells Human Herpesvirus 7  Roseola Infantum CD4T cells Epstein-Barr Virus  Infectious Mono B lymphocytes, salivary Human Herpesvirus 8  Kaposi’s Sarcoma Kaposi’s Sarcoma Tissue Human Herpesviruses www.freelivedoctor.com

A study of HSV-2 recurrence in women www.freelivedoctor.com

Vaccines – live or killed ? www.freelivedoctor.com

FDA approved antiviral drugs www.freelivedoctor.com

Non-equilibrium human virus ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Classification Of Virus[Summary]

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Classification Of Virus[Summary]