RADIESSE® — For Volume and Contours The treatment of individual wrinkles is often not enough to restore a youthful and fresh appearance. In order to counter the effects of gravity and regain a younger shape, the face needs real volume. This can be achieved with a dermal filler which also re-stimulates natural collagen production for effective and lasting volume. Thanks to a special gel-matrix, Radiesse® volumising filler creates immediately visible results. With its fine calcium microspheres Radiesse® volumising filler stimulates the body's natural collagen formation to create long-lasting volume. The gel itself, as well as the microspheres, are completely broken down by the body over time. Radiesse® volumising filler puts volume back exactly where it was. With gentle volumising deeper wrinkles and hollow or sagging cheeks disappear, and the natural facial contours return. Dual effect volume formation Immediate effect due to elastic gel-matrix Long-acting effect thanks to collagen stimulation Safe to use Comprehensive clinical studies confirm effectiveness and tolerance Ask your doctor what Radiesse® volumising filler can do for you

3. Facial Augmentation Nasolabial Fold Mental crease Jaw Line Chin Post-rhinoplasty Marionette Line Cheek Malar Radial Lip Lines

5. Calcium Hydroxylapatite Macrophages dissolve gel carrier & fibroblasts form new collagen. Natural mineral non-antigenic, non-irritant, non-toxic metabolizes via homeostatic mechanisms

6. WSRS = Wrinkle Severity Rating Scale No visible fold, continuous skin line. Absent 1 Shallow but visible fold with a slight indentation; minor facial feature. Implant is expected to produce a slight improvement in appearance. Mild 2 Moderately deep folds. Clear facial feature visible at normal appearance but not when stretched. Excellent correction is expected from injectable implant. Moderate 3 Very long and deep folds; prominent facial feature. Less than 2mm visible fold when stretched. Significant improvement is expected from injectable implant. Severe 4 Extremely deep and long folds, detrimental to facial appearance. 2-4mm Visible V-shaped fold when stretched Unlikely to have satisfactory correction with injectable implant alone. Extreme 5

7. GAIS = Global Aesthetic Improvement Scale The appearance is worse than the original condition. Worse The appearance is essentially the same as the original condition. No Change Obvious improvement in appearance from the initial condition, but a touch-up or re-treatment is indicated. Improved Marked improvement in appearance but not completely optimal for this patient. A touch-up would slightly improve the result. Much Improved Optimal cosmetic result for the implant in this patient. Very Much Improved

9. Split Face Study Volume Comparison > 25% less volume <Volume required

10. Split Face Study GAIS @ 6 Months

11. Split Face Study GAIS @ 9 Months

12. Split Face Study Personal Score Card

13. Results after 1 st treatment Less volume

14. vs Restylane

15. vs Restylane