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ANS Cholinergic
ANS Cholinergic
Nicotinic receptors
Acetyl Co enzyme A and Choline.

NM
Location

Function

NN

Central N

Skeletal NMJ All autonamic
Sensory nerve
post synaptic ganglia and
terminals
adrenal medulla presynaptically

Contraction
NE & E from
Facilitate
of Sk. muscle adrenal medulla release of
Dopamine,
glutamate
Mechanism Ligand gated Ligand gated
channel
channel
M1 (Neuronal
and gastric)

M2 (Cardiac)

M3(Glandular)

M4

M5

Distrib Ganglia, gastric
ution parietal cells,
CNS (cortex,
hippocampus)

Myocardium,
smooth muscle,
presynaptic
PNS,CNS

Exocrine glands,
visceral smooth
muscle, vascular
endothelium

Neostriatum

Substanti
a nigra

Functi
on

Gastric acid
secretion, GI
motility, CNS
excitation

SA node rate of
impulse generation
AV node velocity
and decrease atrial
and ventricular
contraction

Exocrine
secretions.
Smooth muscle
contraction
(expect urinary,
Blood vessels

-

-

Mech

G protein (Gq),
IP3,DAG,depolari
zation

Gi cAmp, opening
of K+ channels

G protein (Gq),
IP3,DAG,depolari
zation

Gi cAmp,
opening of
K+ channels

G (Gq),
IP3,DAG,
depolariz

Agoni
st

Oxotremorine

Methacholine

Bethanechol

-

-

Anta
gonist

Pirenzepine,
Telenzepine

Methoctramine,Tripi 4-DAMP, Hexa
tramine
hydrosiladifenidol
CENTRAL NERVOUS SYSTEM

PARASYMPATHETIC

Brain

Contracts pupil III
Stimulates salivation VII
Spinal
cord

Constricts bronchi X

Slows heartbeat X
Stimulates activity

Stimulates gallbladder
Gallbladder

Contracts bladder
Stimulates erection
of sex organs S
Parasympathomimetics
Directly acting

Indirectly acting

1. Ach

2. Synthetic choline esters

Reversible

Methacholine
Carbachol
Bethanechol

Carbamates
1. Natural alkaloids

3. Natural alkaloids

2. Quaternary

• Muscarine
• Nicotine
• Pilocarpine
• Arecoline

4.Miscellaneous
• Tremorine
• Oxotremorine

• Physostigmine

• Edrophonium
• Neostigmine
• Pyridostigmine
• Ambenonium
• Demecarium
• Rivastigmine
Acridine
Tacrine

Irreversible
1. Organophosphates
• Ecothophate
• Isoflurophate
• Paraoxon
• Parathion
• Malathion
• Diazon

2. Carbamates
• Popoxour
• Carbaryl
Anger, Alert,
Aggressive
Mydriasis

Inc. Muscle tone

Flushing of Face
Bronchodilatation
In. Cardiac output

Liver
Glucogenolysis
More energy prod

Large B vessels
dilate to speed
up blood flow

Lipolysis-Energy
Tyrosine→Dopa→Dopamine→NEpi→Epi
ANS Cholinergic
ANS Cholinergic
ANS Cholinergic
ANS Cholinergic

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ANS Cholinergic

  • 3. Nicotinic receptors Acetyl Co enzyme A and Choline. NM Location Function NN Central N Skeletal NMJ All autonamic Sensory nerve post synaptic ganglia and terminals adrenal medulla presynaptically Contraction NE & E from Facilitate of Sk. muscle adrenal medulla release of Dopamine, glutamate Mechanism Ligand gated Ligand gated channel channel
  • 4. M1 (Neuronal and gastric) M2 (Cardiac) M3(Glandular) M4 M5 Distrib Ganglia, gastric ution parietal cells, CNS (cortex, hippocampus) Myocardium, smooth muscle, presynaptic PNS,CNS Exocrine glands, visceral smooth muscle, vascular endothelium Neostriatum Substanti a nigra Functi on Gastric acid secretion, GI motility, CNS excitation SA node rate of impulse generation AV node velocity and decrease atrial and ventricular contraction Exocrine secretions. Smooth muscle contraction (expect urinary, Blood vessels - - Mech G protein (Gq), IP3,DAG,depolari zation Gi cAmp, opening of K+ channels G protein (Gq), IP3,DAG,depolari zation Gi cAmp, opening of K+ channels G (Gq), IP3,DAG, depolariz Agoni st Oxotremorine Methacholine Bethanechol - - Anta gonist Pirenzepine, Telenzepine Methoctramine,Tripi 4-DAMP, Hexa tramine hydrosiladifenidol
  • 5. CENTRAL NERVOUS SYSTEM PARASYMPATHETIC Brain Contracts pupil III Stimulates salivation VII Spinal cord Constricts bronchi X Slows heartbeat X Stimulates activity Stimulates gallbladder Gallbladder Contracts bladder Stimulates erection of sex organs S
  • 6. Parasympathomimetics Directly acting Indirectly acting 1. Ach 2. Synthetic choline esters Reversible Methacholine Carbachol Bethanechol Carbamates 1. Natural alkaloids 3. Natural alkaloids 2. Quaternary • Muscarine • Nicotine • Pilocarpine • Arecoline 4.Miscellaneous • Tremorine • Oxotremorine • Physostigmine • Edrophonium • Neostigmine • Pyridostigmine • Ambenonium • Demecarium • Rivastigmine Acridine Tacrine Irreversible 1. Organophosphates • Ecothophate • Isoflurophate • Paraoxon • Parathion • Malathion • Diazon 2. Carbamates • Popoxour • Carbaryl
  • 7. Anger, Alert, Aggressive Mydriasis Inc. Muscle tone Flushing of Face Bronchodilatation In. Cardiac output Liver Glucogenolysis More energy prod Large B vessels dilate to speed up blood flow Lipolysis-Energy