The document summarizes a demonstration of the British Pharmacopoeia 2000 on CD-ROM. It has two views: Index+ for intensive searching and Acrobat PDF for browsing. Index+ allows powerful searching using Boolean operators and proximity searches. It provides monograph text that can be selected, copied, and exported. The PDF view presents an accurate representation of the publication that can be navigated and searched, though searching is more limited than in Index+. Both views provide tools to explore the contents of the British Pharmacopoeia 2000 and related publications.

1. Welcome to this demonstration of the
British Pharmacopoeia 2000 on CD-ROM
The screen views comprising this demo will change automatically
There are 2 views of the BP on the CD:
Index+: for intensive searching
Acrobat PDF: for browsing

2. When you open the program you get the ‘Welcome’ screen:

3. Click ‘BP 2000’ to bring up the Index+ home screen
For the moment, note the PDF and BAN tabs; we’ll come back to them shortly. Click on
‘British Pharmacopoeia Volume I’

4. This brings up a view of the sections in Volume I:
Click on ‘Monographs: Medicinal and Pharmaceutical substances.

5. This brings up an A-Z list of the monographs in Volume I:
Note from the tab that you are in ‘Browse’ mode. Scroll the list and click on a
monograph title of interest, eg ‘Albendazole’

6. This brings up the Albendazole monograph. Scroll down to reveal all the text
or click the ‘maximise’ icon to fill the screen. Note that most of the text is in
red. This is to show that the text is either new to the BP 2000 or has been
revised since BP 1999. Graphical elements such as structural formulae, tables
and equations are always black.

7. You now have a choice in the appearance of the text. Go the
Edit menu and click ‘Options’. Click the Font tab.
You have the choice of working with either a serif or sans serif font and with
large or small text; small is recommended

8. Click the Proximity tab; this allows you to set your choice of values for the
‘Near’ operator.
Now click the View tab; this allows you to choose to have monograph titles
repeated in the actual text, useful if you intend copying or exporting the
entire text of a monograph.

9. In this version, 4.0, you can select text. Simply drag across any amount of text.
The selected text can then be copied and pasted into other applications. If you
prefer, you can export a monograph from Index+ as an RTF file by going to
File>Export RTF.

10. Place the cursor over the structural formula.
Note it changes to a pointing hand.
G
G
Now click.

11. This brings up an enlarged view of the structure.
It can be saved as a bitmap (.bmp file) or copied to the clipboard.

12. Text in blue signifies a hypertext link to the cited text.
For example, click on ‘octadecylsilyl silica gel for chromatography.

13. To retrace your steps click the ‘Browse’ button which returns you to the A-Z
list.
To browse a different volume click on the rather small text at the top of the
window ‘2000 British Pharmacopoeia CD-ROM’. This gets you back to the
point where you can begin to browse the other volumes.

14. Searching
Index+ provides a powerful search facility. Click the Search
tab.

15. This brings up a dialogue box in which you key the search
parameters.
Let’s find all the capsules monographs with a dissolution test that uses
hydrochloric acid as the dissolution medium

16. We’ll do this progressively to see how you refine the query to get precisely the
information you need.
First we’ll search on ‘dissolution test’. Key in dissolution test in the text box and
then press the ‘Search’ button:

17. This brings up a Hit List showing 122 hits, meaning 122 monographs that
contain the contiguous words ‘dissolution test’. Scrolling the list shows that
general formulary and tablet monographs have been picked up.

18. Click the Search button to get back to where you were.
Now we can refine the search by including the word ‘capsules’ in the ‘Title’
box and pressing Search once more:

19. This time we only get 25 hits:
Note that since the word ‘capsules’ is one of the search criteria it
is highlighted in yellow.

20. Now we’ll include the words ‘hydrochloric acid’ by clicking the
‘AND’ button. The words ‘AND’, ‘NOT’ and ‘OR’ are known as
‘Boolean Operators’. They are an instruction to the search engine
and not words on which to search.

21. This time we get 16 hits:
Let’s take a look at the text of a hit monograph.
Double-click on ‘Etodolac Capsules’.

22. This brings up the top of the Etodolac monograph.
Click the down-arrow in the vertical scroll bar.

23. This takes us to the first or next occurrence of either of the search
words, in this case ‘hydrochloric acid’.
However….

24. …this result is not exactly what we’re after. The next 2
occurrences of hydrochloric acid are nothing to do with the
dissolution test. We need to refine the search further.
We need to use the ‘NEAR’ operator. This allows you to set a
proximity value - let’s say the words ‘hydrochloric acid’ should be
within 20 words of ‘dissolution test’. Choosing an appropriate
value does require a passing knowledge of BP phraseology.
Click the Search button again.

25. Select the AND operator, click the NEAR button and change the
default value to ‘20’:
Now click the Search button again.

26. This time we only have 8 hits and Etodolac Capsules is not one of
them.

27. Double-click on the first hit, Cefradine Capsules and then click on
the down-arrow in the vertical scroll bar.
The text jumps to the first occurrence of the search words. This time we’ve come
up trumps since hydrochloric acid is the dissolution medium!

28. Carry on clicking the down-arrow to scroll from one occurrence
of the search words to the next.
You will find that each of the 8 hits correctly identifies
hydrochloric acid as the dissolution medium.
This search illustrates the power of Boolean operators to refine
search criteria.

29. Before we take a look at the PDF view let’s go back to the Search
window and see what else is on offer.
Notice there are 2 check boxes, one each for ‘British’ and
‘European’. This simply allows searches to be confined to BP or
EP monographs.

30. Secondly, there is an option to restrict searches to Volume I, Volume II or the BP(Vet)
2000. If the ‘Restrict Search’ box is checked, the tabs referring to these volumes
become live. By default all sections within these volumes will be searched but by
unchecking the appropriate boxes the search can be confined to sections of your
choice.

31. Thirdly, there’s tab labelled ‘BAN’. This allows
British Approved Names 1999 to be searched in exactly the same
way as the pharmacopoeial texts.

32. Now let’s take a look at the PDF view. This uses Adobe Acrobat™ as its
foundation. The following views assume the reader is using Acrobat Reader
4.0x. Click the PDF tab.
The data has been structured into the 11 sections shown.

33. Note
The slides that follow contain screenshots taken from the full version of
Acrobat 4.0. Not all the icons showing in the toolbars will be available in
the version of Acrobat Reader 4.0 supplied with the CD. They may also be
in a different location.

34. Click on ‘Acacia to Liothyronine Sodium’.
This brings up the first screenful of this range of monographs.
Down the left side of the screen you see a bookmark list that allows you to navigate
quickly to the monograph of interest

35. There are several zoom-in option buttons on the tool bar to aid
legibility.

36. There are conventional navigation buttons to pass to
Next, Previous, First and Last page in the current set.

37. You can toggle the bookmark list On and Off.

38. Text can be selected. Click the text icon on the tool bar. The
cursor changes to an I-bar when text can be selected by dragging
in the usual way.

39. To select a graphic click and hold the Text icon and choose the Graphic select
tool from the fly-out selection. The cursor changes to cross-hairs. Drag across
any graphic (includes tables and equations) to select it. It can now be copied
and pasted into most applications.

40. To search in PDF view, you must ensure the Index is loaded. Go
to Edit>Search>Select indexes….

41. …ensure the ‘BP’ index box is checked, and click OK.

42. If ‘BP 2000 Index’ is not shown, click the ‘Add’ button,
navigate to the Index folder and open the file
‘BP Index.pdx’.

43. Now the Search button on the tool bar becomes live (it’s the
smaller of the 2 binoculars icons - the one with text behind).
Click this button.

44. This brings up a somewhat primitive search dialogue:
‘Match Case’ and ‘Proximity’ are self-explanatory but ‘Word Stemming’,
Sounds Like’ and ‘Thesaurus’ are just beyond the scope of this demo.

45. Acrobat assumes the user knows about Boolean operators and
does not provide any prompts towards their use in this dialogue.
To find, for example, all uses of potassium bromide R and potassium
chloride R in infrared spectroscopy key the criteria in the
following way:
Then click the Search button.

46. To show the hit-list click the hit-list button on the tool bar. Since
the Acrobat version has not been fully indexed the hit-list simply
tells you in which sections shown in the title screen a hit occurs.
To view the text containing the first hit click ‘View’.

47. To scroll from hit-to-hit, click the Next and Previous hit scroll
buttons.

48. At all times, to get back to the title screen to begin browsing a
new section of the BP, click the British Pharmacopoeia 2000
button on the taskbar.

49. This completes this demonstration of
BP 2000 on CD-ROM.
To recap:
 The Index+ view provides a very powerful search facility.
 The PDF view gives an accurate, single-column
representation of the text of the book from which the user
can use to browse the publication.
Together, these 2 views provide the user with the tools to explore the
British Pharmacopoeia 2000 (which includes all the data from the 3rd
Edition of the European Pharmacopoeia up to and including
Supplement 2000), the BP (Veterinary) 2000 and British Approved Names
1999 to the fullest extent.