Retionblastoma

Grand Rounds Terry J. Alexandrou, MD Department of Ophthalmology and Visual Science The University of Chicago 1/4/2006

HPI – Patient T.F. ,[object Object],[object Object]

PMH ,[object Object],[object Object]

Meds and Allergies ,[object Object],[object Object]

Family History ,[object Object],[object Object]

Mom complains of a “white pupil in the left eye” ,[object Object]

EXAM ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Retinoblastoma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],“ Cat’s Eye” appearance

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object]

Pathologic features implicated in the past ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

CHILDREN’S ONCOLOGY GROUP ,[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

GOALS AND OBJECTIVES ,[object Object],[object Object],[object Object],[object Object]

Eligibility Criteria ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Unilateral Disease High-Risk Histopathologic Features for which Adjuvant Therapy is Indicated No High-Risk Histopathologic Features for which Adjuvant Therapy is indicated No Metastatic Disease 6 cycles of Chemotherapy Observation Metastatic Disease No Metastatic Disease Follow-up Off Protocol Therapy May enter other protocols Follow-up

High-Risk Histopathologic Features ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

High-Risk Histopathologic Features for which Adjuvant Therapy is Indicated ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Treatment Plan ,[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Retionblastoma

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Retionblastoma