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02 Octobre 2012



© Capsulæ
The key partner in the development
                                          of microencapsulated products
   Capsulæ develops for its clients throughout the industrial world customized solutions
   which facilitate and optimize the performance of ingredients and active compounds,
   via microencapsulation.

   Capsulæ offers a full range of services for developing products and processes based on
   microencapsulation, including the following:
            Design of innovative solutions and Feasibility studies
            Encapsulation problem solving
            Scaling-up studies and Pilot-scale evaluation
            Support at the industrialization stage


© Capsulæ
The key partner in the development
                                         of microencapsulated products
   Created in 2006, the company is the brainchild of three researchers who have an
   accumulated experience of over 50 years in the field of encapsulation of active principles
   for a wide range of applications.

   The management team is made up of:
            Arnaud PICOT, CEO & co-founder
            Samira EL MAFADI, R&D Manager & co-founder
            Denis PONCELET, Scientific Director & co-founder
            Gisèle ONGMAYEB, Project Manager for chemistry applications



© Capsulæ
A technological solution to a multitude
   of industrial problems
   Microencapsulation includes all the technologies that allow the coating or entrapment of
   active ingredients inside individual particles whose size varies from several microns to
   several millimeters.
   Encapsulating an active principle meets 4 main
   objectives which can be combined:
            Immobilization
            Protection or stabilization against
            adverse environmental factors
            Controlled or delayed release on the
            action site
            Functionnalization or structuration

© Capsulæ
A technological solution to a multitude
   of industrial problems
   Developing a process or a product based on micro-
   encapsulation supposes the selection of one method
   among a large number of technologies, the optimization
   of the numerous operating conditions, the definition of
   a formulation.
   The solution must fulfill the particular conditions of the
   application, the project specifications, and respect the
   regulation. The process developed must be scalable to in-
   plant production, taking into account all the technological
   constraints of the industry, and at an acceptable
   manufacturing cost.


© Capsulæ
A unique pluri-technological expertise
                                           pluri-
   The wide range of microencapsulation technologies that the Capsulæ team masters
   allows a great flexibility regarding the solutions we offer our clients, from both a technical
   and economic point of view.

   Our know-how and skills are cover more specifically the following technologies:

            Dripping technologies, as seen in our
            range of solutions




© Capsulæ
A unique pluri-technological expertise
                                           pluri-
   The wide range of microencapsulation technologies that the Capsulæ team masters
   allows a great flexibility regarding the solutions we offer our clients, from both a technical
   and economic point of view.

   Our know-how and skills are cover more specifically the following technologies:

            Emulsion-based technologies, as
            seen in our range of solutions




© Capsulæ
A unique pluri-technological expertise
                                           pluri-
   The wide range of microencapsulation technologies that the Capsulæ team masters
   allows a great flexibility regarding the solutions we offer our clients, from both a technical
   and economic point of view.

   Our know-how and skills are cover more specifically the following technologies:

            Coating technologies, as seen in our
            range of solutions




© Capsulæ
A unique pluri-technological expertise
                                         pluri-
   Capsulæ boasts a wide range of laboratory and pilot equipments that are specifically
   dedicated to microencapsulation, as well as a set of high-performance tools for analysis
   and characterization (microbiological and physico-chemical analyses laboratories):

            Particle size analysis ; Tomography
            Optical microscopy, SEM, CLSM
            Thermal analysis (DSC, TGA) ; DMA
            GC/MS ; HPLC
            FTIR, UV-Vis/Fluorescence ; NMR
            Powder characterization(Aw, %DM, flowability, porosity…)
            Rheological analysis ; Surface tension; Zeta potential
            …


© Capsulæ
A wide range of possible uses
   Microencapsulation can be applied to all sectors of industrial activity.
   Capsulæ has developed its own specific expertise and know-how for the encapsulation of
   active principles in the following domains:




© Capsulæ
Food & Nutrition
   Microencapsulation of food ingredients is useful in meeting a
   number of objectives, including protection during the food
   incorporation process and subsequent storage, taste and odor
   masking and controlled/prolonged release.
   A wide range of functional, lipophilic and hydrophilic ingredients in
   powder or liquid form can be encapsulated, including:

            Probiotic micro-organisms, enzymes
            Vegetable oils, fish oils
            Aromas, fragrances, plant extracts
            Mineral salts, vitamins, amino acids
            …

© Capsulæ
Feed & Animal Health Care
   Whether it be for pets, livestock or even aquaculture,
   microencapsulation greatly facilitates the introduction
   (e.g., reducing dust, improving appetence, formulating
   incompatible compounds), increases stability
   (e.g., phytogenic additives or probiotic micro-organisms
   during pelletizing) and allows for the controlled/delayed
   release (e.g., ruminal bypass for certain vitamins and amino
   acids) of various active principles for multiple applications:

            Complete & complementary feed
            Nutritional specialties & supplements
            Veterinary formulas, vaccines
            Artificial insemination

© Capsulæ
Agriculture & Environment
   Improving products used in crop protection first requires the
   optimization of the biological profile of the active compounds,
   a reduction in the product dose, better flexibility for the user
   and an improved applicability.
   Whether it is for the traditional agro-chemical industry market
   or the biological protection of crops, encapsulation is an
   undeniably essential and effective process, used for the
   following compounds:
            Insecticides and fungicides
            Herbicides and fertilizers
            Repellents and larvicides
            Micro-organisms for soil inoculation, biopesticides

© Capsulæ
Home & Personal Care
   Microencapsulating the main ingredients found in detergents
   significantly improves their effectiveness and greatly
   facilitates their handling. When applied to the personal care
   market, encapsulation provides distinct advantages as it
   enables trapping of volatile compounds, association of
   incompatible ingredients, as well as a product differentiation.
   All these elements constitute determining factors that can
   develop and improve the performance of products such as:
            Cosmetic creams
            Shampoo, toothpaste, soap and shower gels
            Washing powders and washing-up liquids
            Household products

© Capsulæ
Fine & Specialty Chemicals
   The field of fine and specialty chemicals is constantly evolving
   since the emergence of strong regulatory constraints that
   require environmentally-friendly solutions to be developed.

   Capsulae has acquired both skills and expertise in
   developing new techniques using biodegradable materials
   and restricting the use of organic solvents. These techniques
   can be used for the following applications:
            Adhesives & Sealants
            Paints & Coatings
            Building & Construction materials
            Self-Healing & Phase-Change materials

© Capsulæ
A thorough and customized accompaniment
   Our offer is based on the idea of offering an accompaniment that is broken down into
   different stages and specifically adapted to meet the needs of our clients:




© Capsulæ
A thorough and customized accompaniment
   Our offer is based on the idea of offering an accompaniment that is broken down into
   different stages and specifically adapted to meet the needs of our clients:




© Capsulæ
A thorough and customized accompaniment
   Our offer is based on the idea of offering an accompaniment that is broken down into
   different stages and specifically adapted to meet the needs of our clients:




© Capsulæ
A thorough and customized accompaniment
   Our offer is based on the idea of offering an accompaniment that is broken down into
   different stages and specifically adapted to meet the needs of our clients:




© Capsulæ
A thorough and customized accompaniment
   Our offer is based on the idea of offering an accompaniment that is broken down into
   different stages and specifically adapted to meet the needs of our clients:




© Capsulæ
Capsulæ
   Rue de la Géraudière
   BP 82225
   44322 Nantes cedex 3
   FRANCE
       + 33(0)2 40 94 34 62
       contact@capsulae.com
       www.capsulae.com

© Capsulæ
02 Octobre 2012



© Capsulæ

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Présentation Capsulae

  • 2. The key partner in the development of microencapsulated products Capsulæ develops for its clients throughout the industrial world customized solutions which facilitate and optimize the performance of ingredients and active compounds, via microencapsulation. Capsulæ offers a full range of services for developing products and processes based on microencapsulation, including the following: Design of innovative solutions and Feasibility studies Encapsulation problem solving Scaling-up studies and Pilot-scale evaluation Support at the industrialization stage © Capsulæ
  • 3. The key partner in the development of microencapsulated products Created in 2006, the company is the brainchild of three researchers who have an accumulated experience of over 50 years in the field of encapsulation of active principles for a wide range of applications. The management team is made up of: Arnaud PICOT, CEO & co-founder Samira EL MAFADI, R&D Manager & co-founder Denis PONCELET, Scientific Director & co-founder Gisèle ONGMAYEB, Project Manager for chemistry applications © Capsulæ
  • 4. A technological solution to a multitude of industrial problems Microencapsulation includes all the technologies that allow the coating or entrapment of active ingredients inside individual particles whose size varies from several microns to several millimeters. Encapsulating an active principle meets 4 main objectives which can be combined: Immobilization Protection or stabilization against adverse environmental factors Controlled or delayed release on the action site Functionnalization or structuration © Capsulæ
  • 5. A technological solution to a multitude of industrial problems Developing a process or a product based on micro- encapsulation supposes the selection of one method among a large number of technologies, the optimization of the numerous operating conditions, the definition of a formulation. The solution must fulfill the particular conditions of the application, the project specifications, and respect the regulation. The process developed must be scalable to in- plant production, taking into account all the technological constraints of the industry, and at an acceptable manufacturing cost. © Capsulæ
  • 6. A unique pluri-technological expertise pluri- The wide range of microencapsulation technologies that the Capsulæ team masters allows a great flexibility regarding the solutions we offer our clients, from both a technical and economic point of view. Our know-how and skills are cover more specifically the following technologies: Dripping technologies, as seen in our range of solutions © Capsulæ
  • 7. A unique pluri-technological expertise pluri- The wide range of microencapsulation technologies that the Capsulæ team masters allows a great flexibility regarding the solutions we offer our clients, from both a technical and economic point of view. Our know-how and skills are cover more specifically the following technologies: Emulsion-based technologies, as seen in our range of solutions © Capsulæ
  • 8. A unique pluri-technological expertise pluri- The wide range of microencapsulation technologies that the Capsulæ team masters allows a great flexibility regarding the solutions we offer our clients, from both a technical and economic point of view. Our know-how and skills are cover more specifically the following technologies: Coating technologies, as seen in our range of solutions © Capsulæ
  • 9. A unique pluri-technological expertise pluri- Capsulæ boasts a wide range of laboratory and pilot equipments that are specifically dedicated to microencapsulation, as well as a set of high-performance tools for analysis and characterization (microbiological and physico-chemical analyses laboratories): Particle size analysis ; Tomography Optical microscopy, SEM, CLSM Thermal analysis (DSC, TGA) ; DMA GC/MS ; HPLC FTIR, UV-Vis/Fluorescence ; NMR Powder characterization(Aw, %DM, flowability, porosity…) Rheological analysis ; Surface tension; Zeta potential … © Capsulæ
  • 10. A wide range of possible uses Microencapsulation can be applied to all sectors of industrial activity. Capsulæ has developed its own specific expertise and know-how for the encapsulation of active principles in the following domains: © Capsulæ
  • 11. Food & Nutrition Microencapsulation of food ingredients is useful in meeting a number of objectives, including protection during the food incorporation process and subsequent storage, taste and odor masking and controlled/prolonged release. A wide range of functional, lipophilic and hydrophilic ingredients in powder or liquid form can be encapsulated, including: Probiotic micro-organisms, enzymes Vegetable oils, fish oils Aromas, fragrances, plant extracts Mineral salts, vitamins, amino acids … © Capsulæ
  • 12. Feed & Animal Health Care Whether it be for pets, livestock or even aquaculture, microencapsulation greatly facilitates the introduction (e.g., reducing dust, improving appetence, formulating incompatible compounds), increases stability (e.g., phytogenic additives or probiotic micro-organisms during pelletizing) and allows for the controlled/delayed release (e.g., ruminal bypass for certain vitamins and amino acids) of various active principles for multiple applications: Complete & complementary feed Nutritional specialties & supplements Veterinary formulas, vaccines Artificial insemination © Capsulæ
  • 13. Agriculture & Environment Improving products used in crop protection first requires the optimization of the biological profile of the active compounds, a reduction in the product dose, better flexibility for the user and an improved applicability. Whether it is for the traditional agro-chemical industry market or the biological protection of crops, encapsulation is an undeniably essential and effective process, used for the following compounds: Insecticides and fungicides Herbicides and fertilizers Repellents and larvicides Micro-organisms for soil inoculation, biopesticides © Capsulæ
  • 14. Home & Personal Care Microencapsulating the main ingredients found in detergents significantly improves their effectiveness and greatly facilitates their handling. When applied to the personal care market, encapsulation provides distinct advantages as it enables trapping of volatile compounds, association of incompatible ingredients, as well as a product differentiation. All these elements constitute determining factors that can develop and improve the performance of products such as: Cosmetic creams Shampoo, toothpaste, soap and shower gels Washing powders and washing-up liquids Household products © Capsulæ
  • 15. Fine & Specialty Chemicals The field of fine and specialty chemicals is constantly evolving since the emergence of strong regulatory constraints that require environmentally-friendly solutions to be developed. Capsulae has acquired both skills and expertise in developing new techniques using biodegradable materials and restricting the use of organic solvents. These techniques can be used for the following applications: Adhesives & Sealants Paints & Coatings Building & Construction materials Self-Healing & Phase-Change materials © Capsulæ
  • 16. A thorough and customized accompaniment Our offer is based on the idea of offering an accompaniment that is broken down into different stages and specifically adapted to meet the needs of our clients: © Capsulæ
  • 17. A thorough and customized accompaniment Our offer is based on the idea of offering an accompaniment that is broken down into different stages and specifically adapted to meet the needs of our clients: © Capsulæ
  • 18. A thorough and customized accompaniment Our offer is based on the idea of offering an accompaniment that is broken down into different stages and specifically adapted to meet the needs of our clients: © Capsulæ
  • 19. A thorough and customized accompaniment Our offer is based on the idea of offering an accompaniment that is broken down into different stages and specifically adapted to meet the needs of our clients: © Capsulæ
  • 20. A thorough and customized accompaniment Our offer is based on the idea of offering an accompaniment that is broken down into different stages and specifically adapted to meet the needs of our clients: © Capsulæ
  • 21. Capsulæ Rue de la Géraudière BP 82225 44322 Nantes cedex 3 FRANCE + 33(0)2 40 94 34 62 contact@capsulae.com www.capsulae.com © Capsulæ
  • 22. 02 Octobre 2012 © Capsulæ