Woods Anticoag Antianem 09

Anticoagulant, Thrombolytic, and Antiplatelet Drugs Cooper Woods, Ph.D. [email_address]

Homeostasis: Cessation of bleeding from an injured blood vessel ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The hemostatic process is a protective mechanism to prevent blood loss from the circulatory system.

Platelet Adhesion and Aggregation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Blood Coagulation : ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Clotting Time ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Bleeding Disorders ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Thrombosis and Embolism ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],THR

Fibrinolysis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Natural Anti-coagulant Mechanisms ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Anticoagulants (Parenteral) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Anticoagulants (Parenteral) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Anticoagulants (Parenteral) cont. ,[object Object],[object Object],[object Object],[object Object],[object Object]

Anticoagulants (Parenteral) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Anticoagulants (Parenteral) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Anticoagulants (Parenertal) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Anticoagulants (Oral) ,[object Object],[object Object],[object Object],Active form

Anticoagulants (Oral) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Fibrinolytic Drugs: (Thrombolytics) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Thrombolytics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Inhibitors of Fibrinolysis ,[object Object],[object Object],[object Object],[object Object],[object Object]

Antiplatelet Agents - Aspirin ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Antiplatelet Agents - Dipyridamole ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Platelet cAMP ATP Adenosine Adenosine A 2 Receptor Adenylate cyclase

Antiplatelet Agents - Ticlopidine (Ticlid ®) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Antiplatelet Agents - Clopidogrel (Plavix®) ,[object Object],[object Object],[object Object],[object Object]

Antiplatelet Agents – Prasugrel (Effient) ,[object Object],[object Object],[object Object],[object Object]

Wiviott S et al. N Engl J Med 2007;357:2001-2015 Cumulative Kaplan-Meier Estimates of the Rates of Key Study End Points during the Follow-up Period

Antiplatelet Agents ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Antiplatelet Agents – Eptifibatide, Tirofiban ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Hemostatic Agents for Bleeding Disorders ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Hematopoiesis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Hematopoiesis – Erythropoietin ,[object Object],[object Object],[object Object],[object Object]

Antianemia Agents – Erythropoietins ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Iron Metabolism Essential Iron Male(mg/kg) Female(mg/kg) Hemoglobin 31 28 Myoglobin & Enzymes 6 5 Storage 13 4 Total 50 37

Iron Deficiency ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Iron Deficiency - Diagnosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Antianemia Agents Oral Iron Therapy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Antianemia Agents Parenteral Therapy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Copper Deficiency ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Pyridoxine (Vitamin B 6 ) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Megaloblastic Anemias Vitamin B 12 and Folic Acid

Vitamin B 12 and Folic Acid Function ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Antianemia Agents ,[object Object],[object Object],[object Object],[object Object],[object Object]

Antianemia Agents ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Anemia due to Folic Acid Deficiency ,[object Object],[object Object],[object Object],[object Object],[object Object]

Myeloid and Megakaryocyte Growth Factors

Myeloid Growth Factors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Megakaryocyte Growth Factors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Woods Anticoag Antianem 09

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Woods Anticoag Antianem 09