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AcrySof® IQ ReSTOR® Multifocal Toric IOL Con Moshegov Sydney
AcrySof ®   MultiPiece 1994 2000 2003 2004 2005 2006 AcrySof ®   TORIC AcrySof ®   Single Piece AcrySof ®  Product  Portfolio / Timeline AcrySof ®  IQ ReSTOR ®  +3 2008 +3 “ Refractive” Optics
Presbyopia Correcting -IOLs  Most Often Used 2009 Source: 2009 Leaming Survey
ReSTOR ®  & Crystalens ® US Market Share Trends  Source: 3Q09 Market Scope Quarterly Cataract Update  +28.2pt 29.3% 57.5% 45.7% 44.5% Q4-07 Q4-08 Q4-09 30 35 40 45 50 55 60 -1.2pt
 
Overall Spectacle Wear Portion of Time Wearing Glasses Binocular – 6 Months Post op
Overall Spectacle Wear Binocular – 6 Months Post op
13.0 mm Anterior Apodized Diffractive Optic 6.0 mm 6.0 mm Symmetric Biconvex Anterior Aspheric Optic Anatomy of the Apodized  Diffractive Technology
AcrySof ®  IQ ReSTOR ®  IOL SN6AD3 Add Power:  +4.0 D Spectacle Plane: +3.2 D Range: +10.0 D to +34.0 D  A-Constant: 118.9 SN6AD1 Add Power:  +3.0 D Spectacle Plane: +2.5 D Range: +10.0 D to +34.0 D  A-Constant: 118.9
26 28 30 32 34 36 Uncorrected Centimeters (cm) ~6-7 cm difference Source: AcrySof ®  IQ ReSTOR ®  IOL Package Insert 38 Average Near Best Distance IQ ReSTOR ®  IOL +4.0 D  [N=131] IQ ReSTOR ®  IOL +3.0 D  [N=138]
Moshegov ,[object Object],[object Object]
 
Night Vision  Problems Halos Glare AcrySof ReSTOR +4 6 months AcrySof ReSTOR +3 3 months Moderate None, Mild Severe Visual Disturbances
Toric IOL Preferred 2009  Source: 2009 Leaming Survey
IOL Design – Rotational Stability ,[object Object],[object Object],[object Object],[object Object]
 
Measuring axis post-op
IOL rotation ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
 
Post op: Toric vs. LRI Acrysof Toric SN60AT  + LRIs >/= 6/6 56% 24% >/= 6/12 93% 85% Post-op refractive cyl 0.48 D 0.97 D Mean SE -0.45 -0.575
The Latest Advance in AcrySof® Technology Australian launch: November 2010
AcrySof ®  IQ ReSTOR® Multifocal Toric IOL ,[object Object],[object Object]
Cylinder Distribution Cylinder D (  <  ) % of Patients N = 10,411 Moderate  1.0 – 2.0D 25% Severe  >2.0 D 10%
Corrective Cylinder Power
[object Object],[object Object],[object Object],[object Object],[object Object],AcrySof® IQ ReSTOR® Multifocal Toric IOL  Product Evolution ,[object Object],[object Object],[object Object],[object Object]
Cylinder Powers Detail  (Models SND1T2 – T5) * Based on an average pseudophakic human eye IOL Model Cylinder Power @ IOL Plane Cylinder Power @ Corneal Plane* Diopter  Power Available**  0.5D increments  (Spherical Equivalent) SND1T2 1.00 0.68 6.0 to 34.0D SND1T3 1.50 1.03 6.0 to 34.0D SND1T4 2.25 1.55 6.0 to 34.0D SND1T5 3.00 2.06 6.0 to 34.0D
AcrySof® IQ ReSTOR® Multifocal Toric IOL (Model SND1TT) Product Characteristic Summary Table Internal Use Only – For Sales Training Purposes Model Numbers Product  Characteristic SND1T2 * SND1T3 SND1T4 SND1T5 Optic Type Biconvex Apodized Diffractive Aspheric Toric Material  Ultraviolet and blue light filtering Acrylate / Methacrylate Copolymer Optic Diameter (mm) 6.0  Overall Length (mm) 13.0 Haptic Angle 0° IOL Powers (spherical equivalent diopters) Current availability is 10.0 to 30.0 D ( 0.5D increments)  IOL Cylinder Powers (IOL Plane) 1.00 D 1.50 D 2.25 D 3.00 D IOL Cylinder Powers (Corneal Plane) † 0.68 D 1.03 D 1.55 D 2.06 D Add Power +3.0 D Add Power at Spectacle Plane +2.5 D Suggested A-Constant 118.9 † Based on average pseudophakic human eye  * Model number SND1T2  not   currently available.
Product Characteristics Light Transmission Curve
AcrySof® IQ ReSTOR ®  IOL +3.0 D  Theoretical Total Energy Balance S ource:  Data on file.  Alcon, Inc. R&D Technical Report Product Performance  AcrySof® IQ ReSTOR® IOL
Refraction (D) AcrySof® IQ ReSTOR ®  IOL +3.0 D  [N=117] Mean Defocus Curve for AcrySof® IQ +3.0 D ReSTOR® IOL Binocular, Best Case, 6 Months Postoperative S ource:  AcrySof ®  IQ ReSTOR ®  IOL Package Insert 70 cm 50 cm 40 cm 33 cm ∞ 20/25 20/32 20/40 20/50 20/63 20/80 20/100 20/20 +1.00 +0.50 0.00 -0.50 -1.00 -1.50 -2.00 -2.50 -3.00 -3.50 -4.00 Product Performance: IQ ReSTOR® Double Peaked Defocus Curve
Updated Online Calculator www.acrysoftoriccalcular.com
ASICO instruments
PRE-OP TORIC REFERENCE MARKER A.  AE-2791 Marking Eye with Patient Sitting Up B.  Patient Lying Down AE-2791
 
 
Marking of the Eye – Axis Marking
INTRA-OP MARKER A.  AE-2792 Aligned to Steepest Meridian B.  Marks on Steepest Meridian AE-2792
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
ReSTOR +3D Toric
The majority work very well but.. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Concerns ,[object Object]
Concerns ,[object Object]
Concerns ,[object Object]
Concerns ,[object Object]
Ideal patients for the ReSTOR
Ideal patients for the ReSTOR ,[object Object],[object Object],[object Object],[object Object]
Bad patients for the ReSTOR
Intra-operative Exclusion Criteria ,[object Object],[object Object],[object Object],[object Object]
Preoperative counseling ,[object Object],[object Object],[object Object],[object Object],[object Object]
Preoperative counseling ,[object Object],[object Object],[object Object],[object Object]
IQ ReSTOR® Toric  Conclusions ,[object Object],[object Object],[object Object],[object Object]

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AcrySof IQ ReSTOR Toric IOL overview

  • 1. AcrySof® IQ ReSTOR® Multifocal Toric IOL Con Moshegov Sydney
  • 2. AcrySof ® MultiPiece 1994 2000 2003 2004 2005 2006 AcrySof ® TORIC AcrySof ® Single Piece AcrySof ® Product Portfolio / Timeline AcrySof ® IQ ReSTOR ® +3 2008 +3 “ Refractive” Optics
  • 3. Presbyopia Correcting -IOLs Most Often Used 2009 Source: 2009 Leaming Survey
  • 4. ReSTOR ® & Crystalens ® US Market Share Trends Source: 3Q09 Market Scope Quarterly Cataract Update +28.2pt 29.3% 57.5% 45.7% 44.5% Q4-07 Q4-08 Q4-09 30 35 40 45 50 55 60 -1.2pt
  • 5.  
  • 6. Overall Spectacle Wear Portion of Time Wearing Glasses Binocular – 6 Months Post op
  • 7. Overall Spectacle Wear Binocular – 6 Months Post op
  • 8. 13.0 mm Anterior Apodized Diffractive Optic 6.0 mm 6.0 mm Symmetric Biconvex Anterior Aspheric Optic Anatomy of the Apodized Diffractive Technology
  • 9. AcrySof ® IQ ReSTOR ® IOL SN6AD3 Add Power: +4.0 D Spectacle Plane: +3.2 D Range: +10.0 D to +34.0 D A-Constant: 118.9 SN6AD1 Add Power: +3.0 D Spectacle Plane: +2.5 D Range: +10.0 D to +34.0 D A-Constant: 118.9
  • 10. 26 28 30 32 34 36 Uncorrected Centimeters (cm) ~6-7 cm difference Source: AcrySof ® IQ ReSTOR ® IOL Package Insert 38 Average Near Best Distance IQ ReSTOR ® IOL +4.0 D [N=131] IQ ReSTOR ® IOL +3.0 D [N=138]
  • 11.
  • 12.  
  • 13. Night Vision Problems Halos Glare AcrySof ReSTOR +4 6 months AcrySof ReSTOR +3 3 months Moderate None, Mild Severe Visual Disturbances
  • 14. Toric IOL Preferred 2009 Source: 2009 Leaming Survey
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  • 21. Post op: Toric vs. LRI Acrysof Toric SN60AT + LRIs >/= 6/6 56% 24% >/= 6/12 93% 85% Post-op refractive cyl 0.48 D 0.97 D Mean SE -0.45 -0.575
  • 22. The Latest Advance in AcrySof® Technology Australian launch: November 2010
  • 23.
  • 24. Cylinder Distribution Cylinder D ( < ) % of Patients N = 10,411 Moderate 1.0 – 2.0D 25% Severe >2.0 D 10%
  • 26.
  • 27. Cylinder Powers Detail (Models SND1T2 – T5) * Based on an average pseudophakic human eye IOL Model Cylinder Power @ IOL Plane Cylinder Power @ Corneal Plane* Diopter Power Available** 0.5D increments (Spherical Equivalent) SND1T2 1.00 0.68 6.0 to 34.0D SND1T3 1.50 1.03 6.0 to 34.0D SND1T4 2.25 1.55 6.0 to 34.0D SND1T5 3.00 2.06 6.0 to 34.0D
  • 28. AcrySof® IQ ReSTOR® Multifocal Toric IOL (Model SND1TT) Product Characteristic Summary Table Internal Use Only – For Sales Training Purposes Model Numbers Product Characteristic SND1T2 * SND1T3 SND1T4 SND1T5 Optic Type Biconvex Apodized Diffractive Aspheric Toric Material Ultraviolet and blue light filtering Acrylate / Methacrylate Copolymer Optic Diameter (mm) 6.0 Overall Length (mm) 13.0 Haptic Angle 0° IOL Powers (spherical equivalent diopters) Current availability is 10.0 to 30.0 D ( 0.5D increments) IOL Cylinder Powers (IOL Plane) 1.00 D 1.50 D 2.25 D 3.00 D IOL Cylinder Powers (Corneal Plane) † 0.68 D 1.03 D 1.55 D 2.06 D Add Power +3.0 D Add Power at Spectacle Plane +2.5 D Suggested A-Constant 118.9 † Based on average pseudophakic human eye * Model number SND1T2 not currently available.
  • 29. Product Characteristics Light Transmission Curve
  • 30. AcrySof® IQ ReSTOR ® IOL +3.0 D Theoretical Total Energy Balance S ource: Data on file. Alcon, Inc. R&D Technical Report Product Performance AcrySof® IQ ReSTOR® IOL
  • 31. Refraction (D) AcrySof® IQ ReSTOR ® IOL +3.0 D [N=117] Mean Defocus Curve for AcrySof® IQ +3.0 D ReSTOR® IOL Binocular, Best Case, 6 Months Postoperative S ource: AcrySof ® IQ ReSTOR ® IOL Package Insert 70 cm 50 cm 40 cm 33 cm ∞ 20/25 20/32 20/40 20/50 20/63 20/80 20/100 20/20 +1.00 +0.50 0.00 -0.50 -1.00 -1.50 -2.00 -2.50 -3.00 -3.50 -4.00 Product Performance: IQ ReSTOR® Double Peaked Defocus Curve
  • 32. Updated Online Calculator www.acrysoftoriccalcular.com
  • 34. PRE-OP TORIC REFERENCE MARKER A. AE-2791 Marking Eye with Patient Sitting Up B. Patient Lying Down AE-2791
  • 35.  
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  • 37. Marking of the Eye – Axis Marking
  • 38. INTRA-OP MARKER A. AE-2792 Aligned to Steepest Meridian B. Marks on Steepest Meridian AE-2792
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  • 47. Ideal patients for the ReSTOR
  • 48.
  • 49. Bad patients for the ReSTOR
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Notas do Editor

  1. Nearly 28 Million -- Most frequently implanted IOL worldwide !!
  2. crystalens 5.0 launched in December 2006
  3. The AcrySof ® Toric IOL is designed to deliver outstanding rotational stability within the capsular bag.   The STABLEFORCE ® haptic design and the adhesive nature of the AcrySof ® Toric IOL material combine to provide a very high level of rotational stability. This was demonstrated in the clinical study, which showed that the AcrySof ® Toric IOL is stable within the capsular bag, with average rotation of less than 4 degrees 6 months after implantation.   It should be noted that the flexible STABLEFORCE ® haptic design has another important benefit. It allows the IOL to conform to the capsular bag, promoting optimal placement and centration in capsular bags of different sizes. This makes the lens suitable for use in a wide variety of patients.
  4. Internal Use Only - Alcon Confidential
  5. 35% of patients have 1 or more diopters of cyl. 25% have 1-2D, AND 10% HAVE MORE THAN 2D.
  6. The amount of corrective cylinder power varies from 1.5 D to 3.0 D in the three models of the AcrySof ® Toric IOL that will initially be introduced.   The optic design maintains the same central optic thickness for all AcrySof ® Toric IOL models as with monofocal models SA60AT and SN60AT.
  7. Internal Use Only - Alcon Confidential
  8. Internal Use Only - Alcon Confidential
  9. Internal Use Only - Alcon Confidential
  10. Internal Use Only - Alcon Confidential
  11. Internal Use Only - Alcon Confidential
  12. Axis marking: After phacoemulsification, using the reference marks as a guide, the patient’s eye is marked accurately at two positions (180 degrees apart) that define the optimal axis of IOL placement as determined by the AcrySof ® Toric IOL Calculator.
  13. Based on the experience of all diffractive and refractive lenses, it is vital that proper patient selection and screening be employed. Age, functional and occupational requirements, degree of general alertness, and ocular pathology must all be taken into account. Before choosing a lens, it is recommended that consideration be made on the patients visual demands, and their expectation on near vision needs. Patients with pre-existing ocular pathology, or those with high degrees of pre-operative astigmatism, are likely to NOT be ideal candidates. Our recommendation is to choose active, alert patients without existing pathology who have 1.0 diopter or less of pre-operative astigmatism. Bilateral implants are also strongly recommended, to ensure optimal results.