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Probiotics in pediatrics.pptx mmm
1. Probiotics new generation in pediatrics Carlos D. Ramos-Perea M.D. F.A.A.P Catedrรกtico Asociado Escuelas de Medicina Ponce y Central del Caribe Pediatra- Neonatรณlogo- Cuidados Intensivos HOSPITAL MATERNO-INFANTIL SAN ANTONIO MAYAGUEZ, P.R.
12. Lactobacillus contains lactase within their cell wall, adhering to the intestinal microvillus, digesting lactose.
13. Non fermented milk containing L.bulgaricus significantly reduced both breath hydrogen results and symptoms of lactose int. De verse et all am j clin nutr 2001:73
32. Ingestion of Bacteria (Transient Intestinal Bacteria) have a Lengthy History 15 Monks Perfect Fermentation Pasteurization Sumerians (Cheese) Celts & Huns(Kefir) Abraham (Milk & curds) 2000 3500 BC 2000 BC AD Antibiotics Probiotics In the last 100 years, we drastically changed our ingestion of microbes and our microbial environment
50. Predominant flora of breast fed infants19 Bifidobacterium lactis Nomenclature: B. lactis also: B. animalis sub-species lactis, also B. bifidum, strain Bb12
60. Germ free animals revealed underdeveloped mucosal inmune system with very small PEYER patches,decreased lymphocytes in mucosa and absent IGA producing cells.
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62. Antimicrobial activities of probiotics include the (1) production of bacteriocins/ defensins , (2) competitive inhibition with pathogenic bacteria, (3) inhibition of bacterial adherence translocation, and (4) reduction of luminal pH. Probiotics bacteria can also enhance intestinal barrier function by (5) increasing mucus production.
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65. (mechanical defense) Mucus layer Categorized depends on cytokine profile Promote- eos recruitment Encourage T cell prolif. And macrophage activ. Inflammatory defense The balance between T lymph important role in modulating immune response Over expression proinflamatory
73. Increases in acetic acid and scfa similar to breast.
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75. Aโ healthyโ microbial balance will promote Th1 responses and decrease Th2 decreasing allergic and atopic disease.
76. Bifidobacteria and lactobacilli given orally will modulate GALT toward a balance T helper response and stimulate production of I-1O all of them having roles in immune response.
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78. Decrease gut permeability and enhance natural killer cell activity, macrophage activation and phagocytosis.
105. 60 children properly diagnosed, receive 2 sprays per nostril for 10 days with LACTOBACILUS rhamnosun compare with 60 with placebo.30 ptes.(50%) Showed clinical cure of the process vs. only one with placebo.
109. To date 70 clinical studies involving more than 4000 children and infants(term & preterm)consuming infant formula and food containing microbial ingredients with no reports of probiotics adverse side effects.
121. Help maintain a healthy balance of intestinal flora.54 GINI TRIAL * Von Berg 2007
122. Expertos Recomiendan Niveles Medios de LCPUFAs en la Leche Humana para Formulas Infantiles de Niรฑos a Termino % de Acidos Grasos DHA ARA ~0.4 ~0.4 ~0.35 ~0.7 ~0.35 ~0.5 ๏ณ0.2 ๏ณ0.35 Grupo Expertos British Nutrition Foundation (BNF; โ92) Food and Agriculture Organization World Health Organization (FAO/WHO; โ94) Expert Panel convened by NIH/ISSFAL (โ99) Child Health Foundation, Germany (โ01)
130. Benefits of GOOD START NATURAL CULTURES 63 Less curd formation Faster gastric emptying Easy protein digestion Greater stool softness Potential for allergy prevention A good balance of intestinal florasupports a healthy immune system