The National Institutes of Health (NIH) is the primary agency in the United States responsible for biomedical and public health research. It spends $30.9 billion annually, with 83% of funding supporting over 300,000 scientists and 2,500 research institutions. Its mission is the pursuit of fundamental knowledge about living systems and applying that knowledge to extend healthy life and reduce illness. NIH manages a large amount of complex biomedical data across many domains that presents challenges to locate, access, organize, analyze, present, disseminate, and train others on. Its Big Data to Knowledge initiative seeks to address these challenges through creating a central data commons and collaborative research environment to maximize scientific discovery and knowledge generation from NIH funded research data