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아스피린의 부작용.
             200619864 배재현
 CH3OC-NH-C6H4-OH
 항염증제는 아니지만, 통증이나 열을 조절할 수 있다


 비스테로이성항염증약물과 달리 위와 신장에 대한 부
 작용이 없어 장복 시 에도 비교적 안전하게 사용할 수
 있음

 가격도 쌈.
 해열진통효과는 좋으나 소염작용이 거의없다.


 간독성이나 소아에 Methemoglobinemia부작용이 발
 생할 수 있으나 극히 드문 경우이다.
위


폐


간
 아스피린은, 위점막을 유지하는 프로스타글란딘이라
 는 물질이 만들어지지 못하도록 하기 때문에 위벽의
 보호기능을 떨어뜨린다.

 이부 프로펜 나프록센 등 다른 소염진통제다 마찬가지
 다.
 폐에서 glutathione과 antioxidant의 농도을 감소시키
 고, 감소된 glutathione은 취약한 천식환자에게
 oxidative stress를 주어 폐 기능을 약화시키며, 산화 작
 용은 leukotriene을 분비시키고 bronchospasm을 일으
 킨다
 간 수치 증가가 흔하고Reye 증후군의 위험성이 있는
 단점이 있다 또한 naproxen은 드물게 얼굴, 손,등 햇빛
 에 노출되는 부위에 bullouser uption을 일으키고 때때
 로 얕은 흉터를 남기는 cutaneous pseudoporphyria가
 생길 수 있고굚 tolmetin은 효과적인 항염증제이나 장
 천공이 발생할 수 있다
 2세 미만


 단기간(평균 3일) 복용 후 4주간을 관찰


 acetaminophen 12mg/kg
 다른 소염 진통제보다 효능과 부작용에서 별 차이 없
 이 우수했다.

 3명의 어린이가 gastrointestinal bleeding으로 입원 하
 였는데, 3명 모두 ibuprofen을 복용한 그룹이었다
 http://www.medicalobserver.co.kr/FileUpLoad/H12/39
 0701-24032008999.pdf

 http://blog.daum.net/_blog/BlogView.do?blogid=09M
 4T&articleno=17423821&_bloghome_menu=recenttext
 #ajax_history_home

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3. 배재현 (치료약물의 독성)

  • 1. 아스피린의 부작용. 200619864 배재현
  • 3.  항염증제는 아니지만, 통증이나 열을 조절할 수 있다  비스테로이성항염증약물과 달리 위와 신장에 대한 부 작용이 없어 장복 시 에도 비교적 안전하게 사용할 수 있음  가격도 쌈.
  • 4.  해열진통효과는 좋으나 소염작용이 거의없다.  간독성이나 소아에 Methemoglobinemia부작용이 발 생할 수 있으나 극히 드문 경우이다.
  • 6.  아스피린은, 위점막을 유지하는 프로스타글란딘이라 는 물질이 만들어지지 못하도록 하기 때문에 위벽의 보호기능을 떨어뜨린다.  이부 프로펜 나프록센 등 다른 소염진통제다 마찬가지 다.
  • 7.  폐에서 glutathione과 antioxidant의 농도을 감소시키 고, 감소된 glutathione은 취약한 천식환자에게 oxidative stress를 주어 폐 기능을 약화시키며, 산화 작 용은 leukotriene을 분비시키고 bronchospasm을 일으 킨다
  • 8.  간 수치 증가가 흔하고Reye 증후군의 위험성이 있는 단점이 있다 또한 naproxen은 드물게 얼굴, 손,등 햇빛 에 노출되는 부위에 bullouser uption을 일으키고 때때 로 얕은 흉터를 남기는 cutaneous pseudoporphyria가 생길 수 있고굚 tolmetin은 효과적인 항염증제이나 장 천공이 발생할 수 있다
  • 9.  2세 미만  단기간(평균 3일) 복용 후 4주간을 관찰  acetaminophen 12mg/kg
  • 10.  다른 소염 진통제보다 효능과 부작용에서 별 차이 없 이 우수했다.  3명의 어린이가 gastrointestinal bleeding으로 입원 하 였는데, 3명 모두 ibuprofen을 복용한 그룹이었다
  • 11.  http://www.medicalobserver.co.kr/FileUpLoad/H12/39 0701-24032008999.pdf  http://blog.daum.net/_blog/BlogView.do?blogid=09M 4T&articleno=17423821&_bloghome_menu=recenttext #ajax_history_home