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02.03 adult art monitoring, changing gsn
- 1. UNIT 3 Monitoring/changing /stopping Highly Active Anti Retroviral Therapy (HAART) and drug interactions:
- 14. Summary Schedule of Laboratory Monitoring X X 1 X (if on TDF) X X 6m X X X Fasting lipids & glucose (PIs) X X X X (if on NVP) X (if on NVP) X ALT(LFT) X 1 X 1 X 1 X 1 X 1 X Pregnancy test X (if on TDF X (if on TDF) X (if on TDF X (if on TDF) X (if on TDF) X Serum Creatinine X X X X (if on AZT) X (if on AZT) X CBC + Differential X X X X CD4 24m 18m 12m 3m 1-2 months Baseline Test
- 22. A Rational Approach to the Management of Serious Side Effects Refer to “The National Clinical Manual for ARV Providers”
- 38. 2. Drug Interactions It is not possible to remember all the possible drugs interactions with ARV’s Refer to “The National ARV Guidelines”
- 46. 3. Treatment Failure Refer to “The National Clinical Manual for ARV Providers”
- 51. CAUSES OF FAILURE OF ART: INFLUENCE OF FOOD ON ART ABSORPTION Drug Fasting Low High Recommen- fat meal fat meal dation Indinavir + + - Fasting Indinavir+Ritovinar) + + + None Nelfinavir - + + Meal Amprinavir + + - No High fat meal Navirapine + + + None Delavaridine + - - Fasting Efavirenz + + + none
- 52. CAUSES OF FAILURE OF ART: Pill Burden
Notas do Editor
- X1: If clinically indicated Serum Creatinine not needed for standard 1 st line; required more regularly in patients on TDF. Red X are for tests necessitated by those particular drugs. Most patients can be adequately monitored 6 monthly and as clinically indicated
- Average CD4 count rise