27. respiratory 2-07-08

Saúde e medicina Negócios

R E S P I R A T O R Y S Y S T E M GAS EXCHANGE

PULMONARY GAS EXCHANGE ,[object Object],[object Object],[object Object]

GAS EXCHANGE IN THE LUNGS ,[object Object],[object Object]

GAS EXCHANGE IN THE LUNGS ,[object Object],[object Object],[object Object],[object Object],[object Object]

PULMONARY BLOOD GASES ,[object Object],[object Object]

PULMONARY DIFFUSION ,[object Object],[object Object]

GAS EXCHANGE IN PERIPHERAL TISSUES ,[object Object],[object Object]

GAS TRANSPORT IN BLOOD ,[object Object],[object Object],[object Object],[object Object]

OXYGEN DISSOCIATION CURVE ,[object Object]

CARBON DIOXIDE TRANSPORT ,[object Object],[object Object],[object Object],[object Object]

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Supply of oxygen to tissues mainly involves two systems i.e. respiratory system and the cardiovascular system. Supply of oxygen to tissues depends upon Adequate PO2 in atmospheric air Adequate pulmonary ventilation Adequate gaseous exchange in the lungs Adequate uptake of oxygen by the blood Adequate blood flow to the tissues Adequate ability of the tissues to utilize oxygen Oxygen diffuses from the alveoli into the pulmonary capillary blood because the oxygen partial pressure (Po2) in the alveoli is greater than the Po2 in the pulmonary capillary blood. In the other tissues of the body, a higher Po2 in the capillary blood than in the tissues causes oxygen to diffuse into the surrounding cells. The Po2 of the gaseous oxygen in the alveolus averages 104 mm Hg, whereas the Po2 of the venous blood entering the pulmonary capillary at its arterial end averages only 40 mm Hg Therefore, the initial pressure difference that causes oxygen to diffuse into the pulmonary capillary is 104 – 40, or 64 mm Hg. About 98 percent of the blood that enters the left atrium from the lungs has just passed through the alveolar capillaries and has become oxygenated up to a Po2 of about 104 mm Hg. Another 2 per cent of the blood which supplies mainly the deep tissues of the lungs and is not exposed to lung air. This blood flow is called “shunt flow,” meaning that blood is shunted past the gas exchange areas One gram of Hb can bind 1.34 ml of Oxygen Normal level of Hb is 15 grams/dL Thus 15 grams of hemoglobin in 100 milliliters of blood can combine with a total of almost exactly 20 milliliters of oxygen if the hemoglobin is 100 per cent saturated This is usually expressed as 20 volumes per cent Hemoglobin is a conjugated protein consisting of heme and globin. The ferrous form can bind oxygen. Hemoglobin molecule consists of four subunits each consists of one heme and one polypeptide chain Each subunit can bind one molecule of Oxygen Oxygenation is a very rapid and reversible process and it can occur in 0.01 seconds When PO2 is high, oxygen binds with Hb to form Oxyhemoglbin When PO2 is low oxygen leaves Hb to form Deoxy Hb. Factors that shift the oxygen hemoglobin dissociation curve

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