9. Lin- , Sca+ , c-Kit+ , CD 150+ (LSKCD150) Lin- , Sca+ , c-Kit+ , Cd34- , (LSKCD34-) Hoxa9/b3/b4 null mice exhibit an increase in the frequency of immunophenotypic HSCs
10. Loss of hoxb3 and hoxb4 does not exacerbate the repopulating defect observed in hoxa9¯’¯HSCs The key question emerging from this study is why the deficiency of hoxa9 alone results in such dramatic reduction in repopulating capacity and is not significantly compromised by the additional deletions (hoxb3/b4) ?
11.
Notas do Editor
Hoxa9/hoxb3/hoxb4 compound null mice display severe hematopoietic defects