Bioinformatics

Bioinformatics ,[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Outline http://gila.engr.uic.edu/bioinformatics/

DNA Protein Nucleotides sequence Gene expression = Protein production

Biological Diversity Bacteria Fruit Fly Human Yeast

The Genetic Code ,[object Object],[object Object]

From protein sequence to Structure ,[object Object],=

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Bioinformatics http://gila.engr.uic.edu/bioinformatics/

[object Object],[object Object],[object Object],[object Object],[object Object],Bioinformatics in BioE http://gila.engr.uic.edu/bioinformatics/

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Research

Gene expression Computational analysis of cDNA microarray expression profiles ~26,000 genes in one experiment

Functional correlation in clusters 1. Cell division 2. cell signaling/cell communication 3. cell structure/motility 4. cell/organism defense 5. gene/protein expression 6. metabolism 7. unclassified ,[object Object],[object Object]

How Proteins Interfaces with Other Molecules ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Research – structure & function

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Structural genomics/proteomics

Voronoi Diagram and Delaunay Triangulation Geometry based approach for functional motifs Discrete Flow

3D alpha shapes (HIV-1 protease)‏

What is an algorithm? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Are computers fast enough? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

A Server for Identification of Protein Pockets & Cavities CASTp http://cast.engr.uic.edu/ Users of CASTp: Columbia, Harvard, Mayo Clinic, Princeton, Stanford, U Penn, SUNY Stony Brook, Texas A&M, UCIrvine, UBC, Virginia Tech, Yale, Abbott Lab, Pfizer, SmithKline Beecham, ... Agouron, Emisphere, Vertex, ... Kyoto U, Cambridge, European Molecular Biology Lab, INRA (France), Pasteur-Lille, Uppsala, Weizman,... Brazil, Czech, Korea, Turkey, ...

CASTp Results ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],http://cast.engr.uic.edu/

Bioinformatics

Recomendados

Recomendados

Mais conteúdo relacionado

Mais procurados

Mais procurados (20)

Semelhante a Bioinformatics

Semelhante a Bioinformatics (20)

Último

Último (20)

Bioinformatics