6. EXAMPLE-02 SYNTHESIS MeCOCl AlCl 3 HBr Mg Et 2 O H 3 O + TM
7. Conversion of acid from bromo compound Overall reaction Cyanide displacement Not possible due to two -methyl group Grignard reagent can not be used because carbonyl group is also present in bromo compound Solution 1. Protect carbonyl group as ketal 2. Use Grignard reagent 3. Hydrolyzed the ketal group to ketone