Pharm immuno12 &13 tolerance & autoimmunity

Pharm-Immuno 12&13 Immunologic Tolerance & Autoimmunity Dr. Saber Hussein

Objectives ,[object Object],[object Object],[object Object],[object Object]

Tolerance & Anergy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Central & peripheral tolerance to self Ags ,[object Object],[object Object],[object Object],[object Object]

Consequences of the lymphocyte-Ag encounter ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Fig 9-1

Tolerance induction ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Mechanisms that induce self-tolerance ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

T Cell Positive & Negative Selection in the Thymus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

IL-2 synthesis is controlled by costimulatory signals ,[object Object],[object Object],[object Object]

Ags can induce any of the following: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

T cell & B cell tolerance ,[object Object],[object Object],[object Object],[object Object],[object Object]

Advantages & disadvantages of tolerance ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Autoimmunity/Objectives ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Autoimmunity, definition, mechanism ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Etiologies of autoimmune diseases ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Tolerance Autoimmunity ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Mechanisms of bypassing the absence of T H cells ,[object Object],[object Object],[object Object],[object Object],[object Object]

Postulated mechanisms of autoimmunity ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Fig 9-3

Central T cell tolerance ,[object Object],[object Object],[object Object],[object Object],Fig 9-4 ( CD4 & DC8 )

T cell anergy ,[object Object],[object Object],[object Object],[object Object],[object Object],Fig 9-5

Activation-induced death of T cells ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Fig9-6 1 2 3 Death R .

T cell-mediated suppression of immune responses ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Fig9-7

Tolerance or activation? ,[object Object],[object Object],Fig 9-8

Negative selection and receptor editing in immature B lymphocytes ,[object Object],[object Object],[object Object],[object Object],[object Object],Fig9-9

Peripheral tolerance in B cells ,[object Object],[object Object],Fig9-10

Autoimmune disease association with alleles of MHC locus ,[object Object],[object Object],[object Object],[object Object],[object Object]

Ankylosing spondylitis ,[object Object]

Association of autoimmune diseases with alleles of the MHC locus MHC II allele Fig9-11 Skin disease characterized by groups of itching blisters

The roles of some non-MHC genes in auto-immunity ,[object Object],[object Object],[object Object],[object Object],[object Object],A uto I mmune R egulator poly E ndocrine Fig9-12

Mechanisms by which microbes may promote auto-immunity ,[object Object],[object Object],[object Object],[object Object],[object Object],Fig.9-13

Autoimmune diseases ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Rheumatoid Arthritis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Pharm immuno12 &13 tolerance & autoimmunity

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Pharm immuno12 &13 tolerance & autoimmunity