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Chromatin, Inc.
Redesigning crops for agriculture and bioenergy


 CEO’s Life Science Conference – Kuala Lumpur

                October 6, 2009

                Daphne Preuss




                                             Chromatin, Inc.
Chromatin overview


 !! Developed a leading innovation for modifying crops
    !!Allows addition of multiple genes to a plant in a single step


 !! Market access via the world’s premier agricultural companies
    !!Corn, soybean, canola, cotton and sugarcane


 !! Financing raised in Q4 2008 to improve energy crops




                                                                 Chromatin, Inc.
Market for gene stacks

                           Biotech crop sales                                                Stacked Traits

                     8.0                                                             40




                                                                  % Stacked Traits
      Sales ($Billion)




                     6.0                                                             30



                     4.0                                                             20
                                                                                                              3 genes

                     2.0                                                             10

                                                                                              1-2 genes
                     0.0
                                                                                     0.0
                             00 01 02 03 04 05 06 07 08                                    00 01 02 03 04 05 06 07 08




  By 2010, Monsanto & Dow will use breeding to stack 8 different pest and herbicide
    resistance genes in corn (Smartstax™)

  1                      x       2    x     3     x       4   X                 5            x     6      x      7      x   8

                                                                                                                 Chromatin, Inc.
Chromatin’s Gene Stacking Technology

         Gene Stack             Assembled Mini-chromosome         Improved Crop

                                                                  Higher yield
                                                                  More nutritious
    A B C D E F G H I J K L             +                         More biomass
                                                                  Higher value products


    Benefits                                                Validation
    •! Accelerates product                                  •! Peer-review publications:
       development pipelines                                   PLoS Genetics, (2007)
                                                               Carlson et al.
    •! Any crop
                                                               Chromosoma, (2009)
    •! Faster development,                                     Ananiev et al.
       lower costs                   Mini-chromosomes
                                                            •! 15 issued patents;
                                      Single-step gene         >35 applications pending
    •! Streamlined regulatory
                                     stack delivery into
       process
                                           plants


4                                                                        Chromatin, Inc.
Chromatin’s licenses to industry leaders


 •! Non-exclusive: corn, soybean, cotton, canola

 •! Exclusive: sugarcane (+ others under discussion)

 •! Chromatin retains rights to improvements

 •! Payments:
    -! Fees
    -! Milestones
    - Royalties




                                                       Chromatin, Inc.
Crop-specific market strategy

                         Mini-                             Crops &
                                 +     Genes          +              +     End User
                     Chromosomes                          Feedstocks


   Non-exclusive
                                        Partnerships in traditional agriculture
  traditional crop    Chromatin              (corn, soy, cotton, canola)
      licenses

   Exclusive co-                  Owned / licensed
   development        Chromatin     by Chromatin           Partner          Partner
   relationships                  and / or partners


    Proprietary                                             Owned /
                                  Owned / licensed
     product          Chromatin    by Chromatin
                                                          licensed by       Partner
   development                                             Chromatin




                                                                        Chromatin, Inc.
Energy crops


 !!   Most significant cost of biofuel production
       !! ~70% of biorefinery costs

 !!   Most have not been optimized through breeding
       !! Agronomic yields are suboptimal
       !! Crop cultivation (planting, harvesting, seed / pest treatment) is undeveloped

 !!   Most have not been bred for “energy” traits
       !! Inconsistent quality reduces yield




                                                                         Chromatin, Inc.
Optimizing energy crops requires many genetic changes

 Genes on the market today:                Energy traits:
 •! Insect resistance
 •! Herbicide resistance                   •! Improved feedstock conversion

                                               -! Biomass yield
 Genes in industry pipelines:                  -! Cellulose recalcitrance
 •! Better insect / herbicide resistance
 •! Increased seed yield                       -! Enzymes
 •! Reduced nitrogen use
                                           •! Optimized product selectivity
 •! Drought tolerance
 •! Healthy oils                               -! Minimized by-product (CO2)
 •! Amylase
                                           •! Optimized processing efficiencies

 Other agronomic traits:                       •! Feedstock + yeast + enzymes
 •! Viral / bacterial resistance               •! Lower energy / chemicals use
 •! Cold / heat / salt tolerance
 •! Water and nutrient use                     •! Faster fermentation cycles


                                                                        Chromatin, Inc.
Chromatin’s Energy Crop Improvement Platform



    Feedstock   Molecular   Transgenic   Value-added
      Traits    Breeding     Breeding      Hybrids
                                                           Feedstock
                                                            Products
                                         Production
       Proprietary Technology             partners




                                                             Ethanol
                                                             Butanol
                                                          Hydrocarbons
                                                           Monomers
                                                            Polymers

9                                                      Chromatin, Inc.
Management Team

      Over 100 years expertise spanning agriculture, biotech & energy


     Daphne Preuss   •! Co-Founder & CEO




      Jeff Scheib    •! VP Biofuels (Previously BP and Cilion)




     Ken Davenport   •! VP Strategic Development (Previously Bayer and ArborGen)




      Ken Moonie     •! Business Development


10                                                                 Chromatin, Inc.
Investors and operations




                                         Raised $24M total




      Chicago         Champaign-Urbana


                                             + Field sites



                                                 Chromatin, Inc.
Chromatin, Inc.
   Redesigning crops for agriculture and bioenergy




•! Disruptive technology platform

•! Strategic alliances to bring
   technology to existing markets

•! Expanding platform to improve
   energy crops

                                        Chromatin, Inc.

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09 CeoMeeting- Session 3- Chromatin

  • 1. Chromatin, Inc. Redesigning crops for agriculture and bioenergy CEO’s Life Science Conference – Kuala Lumpur October 6, 2009 Daphne Preuss Chromatin, Inc.
  • 2. Chromatin overview !! Developed a leading innovation for modifying crops !!Allows addition of multiple genes to a plant in a single step !! Market access via the world’s premier agricultural companies !!Corn, soybean, canola, cotton and sugarcane !! Financing raised in Q4 2008 to improve energy crops Chromatin, Inc.
  • 3. Market for gene stacks Biotech crop sales Stacked Traits 8.0 40 % Stacked Traits Sales ($Billion) 6.0 30 4.0 20 3 genes 2.0 10 1-2 genes 0.0 0.0 00 01 02 03 04 05 06 07 08 00 01 02 03 04 05 06 07 08 By 2010, Monsanto & Dow will use breeding to stack 8 different pest and herbicide resistance genes in corn (Smartstax™) 1 x 2 x 3 x 4 X 5 x 6 x 7 x 8 Chromatin, Inc.
  • 4. Chromatin’s Gene Stacking Technology Gene Stack Assembled Mini-chromosome Improved Crop Higher yield More nutritious A B C D E F G H I J K L + More biomass Higher value products Benefits Validation •! Accelerates product •! Peer-review publications: development pipelines PLoS Genetics, (2007) Carlson et al. •! Any crop Chromosoma, (2009) •! Faster development, Ananiev et al. lower costs Mini-chromosomes •! 15 issued patents; Single-step gene >35 applications pending •! Streamlined regulatory stack delivery into process plants 4 Chromatin, Inc.
  • 5. Chromatin’s licenses to industry leaders •! Non-exclusive: corn, soybean, cotton, canola •! Exclusive: sugarcane (+ others under discussion) •! Chromatin retains rights to improvements •! Payments: -! Fees -! Milestones - Royalties Chromatin, Inc.
  • 6. Crop-specific market strategy Mini- Crops & + Genes + + End User Chromosomes Feedstocks Non-exclusive Partnerships in traditional agriculture traditional crop Chromatin (corn, soy, cotton, canola) licenses Exclusive co- Owned / licensed development Chromatin by Chromatin Partner Partner relationships and / or partners Proprietary Owned / Owned / licensed product Chromatin by Chromatin licensed by Partner development Chromatin Chromatin, Inc.
  • 7. Energy crops !! Most significant cost of biofuel production !! ~70% of biorefinery costs !! Most have not been optimized through breeding !! Agronomic yields are suboptimal !! Crop cultivation (planting, harvesting, seed / pest treatment) is undeveloped !! Most have not been bred for “energy” traits !! Inconsistent quality reduces yield Chromatin, Inc.
  • 8. Optimizing energy crops requires many genetic changes Genes on the market today: Energy traits: •! Insect resistance •! Herbicide resistance •! Improved feedstock conversion -! Biomass yield Genes in industry pipelines: -! Cellulose recalcitrance •! Better insect / herbicide resistance •! Increased seed yield -! Enzymes •! Reduced nitrogen use •! Optimized product selectivity •! Drought tolerance •! Healthy oils -! Minimized by-product (CO2) •! Amylase •! Optimized processing efficiencies Other agronomic traits: •! Feedstock + yeast + enzymes •! Viral / bacterial resistance •! Lower energy / chemicals use •! Cold / heat / salt tolerance •! Water and nutrient use •! Faster fermentation cycles Chromatin, Inc.
  • 9. Chromatin’s Energy Crop Improvement Platform Feedstock Molecular Transgenic Value-added Traits Breeding Breeding Hybrids Feedstock Products Production Proprietary Technology partners Ethanol Butanol Hydrocarbons Monomers Polymers 9 Chromatin, Inc.
  • 10. Management Team Over 100 years expertise spanning agriculture, biotech & energy Daphne Preuss •! Co-Founder & CEO Jeff Scheib •! VP Biofuels (Previously BP and Cilion) Ken Davenport •! VP Strategic Development (Previously Bayer and ArborGen) Ken Moonie •! Business Development 10 Chromatin, Inc.
  • 11. Investors and operations Raised $24M total Chicago Champaign-Urbana + Field sites Chromatin, Inc.
  • 12. Chromatin, Inc. Redesigning crops for agriculture and bioenergy •! Disruptive technology platform •! Strategic alliances to bring technology to existing markets •! Expanding platform to improve energy crops Chromatin, Inc.